5T5C
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5GKC
| The crystal structure of the CPS-6 H148A/F122A | 分子名称: | Endonuclease G, mitochondrial | 著者 | Lin, J.L, Yuan, H.S. | 登録日 | 2016-07-04 | 公開日 | 2016-11-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.892 Å) | 主引用文献 | Crystal structure of endonuclease G in complex with DNA reveals how it nonspecifically degrades DNA as a homodimer. Nucleic Acids Res., 44, 2016
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5FGU
| Structure of Sda1 nuclease apoprotein as an EGFP fixed-arm fusion | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Green fluorescent protein,Extracellular streptodornase D, ... | 著者 | Moon, A.F, Krahn, J.M, Xun, L, Cuneo, M.J, Pedersen, L.C. | 登録日 | 2015-12-21 | 公開日 | 2016-03-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.896 Å) | 主引用文献 | Structural characterization of the virulence factor Sda1 nuclease from Streptococcus pyogenes. Nucleic Acids Res., 44, 2016
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3WAX
| Crystal Structure of Autotaxin in Complex with 3BoA | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Nishimasu, H, Ishitani, R, Nureki, O. | 登録日 | 2013-05-09 | 公開日 | 2013-07-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.899 Å) | 主引用文献 | Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe Acs Chem.Biol., 8, 2013
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5S9L
| AUTOTAXIN, 4-[3-Oxo-3-(2-oxo-2,3-dihydro-benzooxazol-6-yl)-propyl]-piperazine-1-carboxylic acid 3,5-dichloro-benzyl ester, 1.90A, P212121, Rfree=19.1% | 分子名称: | (3,5-dichlorophenyl)methyl 4-[3-oxo-3-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)propyl]piperazine-1-carboxylate, ACETATE ION, CALCIUM ION, ... | 著者 | Stihle, M, Hunziker, D, Benz, J, Mattei, P, Rudolph, M.G. | 登録日 | 2021-03-31 | 公開日 | 2022-04-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal Structure of a rat Autotaxin complex To be published
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1ZM8
| Apo Crystal structure of Nuclease A from Anabaena sp. | 分子名称: | MANGANESE (II) ION, Nuclease, SODIUM ION, ... | 著者 | Ghosh, M, Meiss, G, Pingoud, A, London, R.E, Pedersen, L.C. | 登録日 | 2005-05-10 | 公開日 | 2005-06-21 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Insights into the Mechanism of Nuclease A, a beta beta alpha Metal Nuclease from Anabaena. J.Biol.Chem., 280, 2005
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6AEL
| Crystal structure of ENPP1 in complex with 3'3'-cGAMP | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, ... | 著者 | Kato, K, Nishimasu, H, Hirano, S, Hirano, H, Ishitani, R, Nureki, O. | 登録日 | 2018-08-05 | 公開日 | 2019-03-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1. Nat Commun, 9, 2018
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5LIA
| Crystal structure of murine autotaxin in complex with a small molecule inhibitor | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Turnbull, A.P, Shah, P, Cheasty, A, Raynham, T, Pang, L, Owen, P. | 登録日 | 2016-07-14 | 公開日 | 2016-11-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Discovery of potent inhibitors of the lysophospholipase autotaxin. Bioorg. Med. Chem. Lett., 26, 2016
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5FGW
| Structure of Sda1 nuclease with bound zinc ion | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | 著者 | Moon, A.F, Krahn, J.M, Xun, L, Cuneo, M.J, Pedersen, L.C. | 登録日 | 2015-12-21 | 公開日 | 2016-03-30 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural characterization of the virulence factor Sda1 nuclease from Streptococcus pyogenes. Nucleic Acids Res., 44, 2016
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8C4W
| Crystal structure of rat autotaxin and compound MEY-002 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5,7-bis(oxidanyl)-2-[1-(phenylmethyl)indol-3-yl]chromen-4-one, 7alpha-hydroxycholesterol, ... | 著者 | Eymery, M.C, McCarthy, A.A. | 登録日 | 2023-01-05 | 公開日 | 2023-11-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery of potent chromone-based autotaxin inhibitors inspired by cannabinoids. Eur.J.Med.Chem., 263, 2023
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5M0E
| Structure-based evolution of a hybrid steroid series of Autotaxin inhibitors | 分子名称: | 7alpha-hydroxycholesterol, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | 著者 | Keune, W.-J, Heidebrecht, T, Perrakis, A. | 登録日 | 2016-10-04 | 公開日 | 2017-08-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators. J. Med. Chem., 60, 2017
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3WAW
| Crystal Structure of Autotaxin in Complex with 2BoA | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Nishimasu, H, Ishitani, R, Nureki, O. | 登録日 | 2013-05-09 | 公開日 | 2013-07-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.954 Å) | 主引用文献 | Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe Acs Chem.Biol., 8, 2013
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6M3F
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6W35
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5HRT
| Crystal structure of mouse autotaxin in complex with a DNA aptamer | 分子名称: | CALCIUM ION, CHLORIDE ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | 著者 | Kato, K, Nishimasu, H, Morita, J, Ishitani, R, Nureki, O. | 登録日 | 2016-01-24 | 公開日 | 2016-04-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Structural basis for specific inhibition of Autotaxin by a DNA aptamer Nat.Struct.Mol.Biol., 23, 2016
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7Z3K
| Autotaxin in complex with orthosteric site-binder CpdA | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ... | 著者 | Salgado-Polo, F, Ford, P, Heckmann, B, Perrakis, A. | 登録日 | 2022-03-02 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Autotaxin facilitates selective LPA receptor signaling. Cell Chem Biol, 30, 2023
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6LEH
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5DLV
| Crystal structure of Autotaxin (ENPP2) with tauroursodeoxycholic acid (TUDCA) | 分子名称: | 2-{[(3alpha,5beta,7alpha,8alpha,14beta,17alpha)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | 著者 | Keune, W.J, Heidebrecht, T, von Castelmur, E, Joosten, R.P, Perrakis, A. | 登録日 | 2015-09-07 | 公開日 | 2016-04-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. Nat Commun, 7, 2016
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3NKM
| Crystal structure of mouse autotaxin | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Nishimasu, H, Ishitani, R, Mihara, E, Takagi, J, Aoki, J, Nureki, O. | 登録日 | 2010-06-20 | 公開日 | 2011-01-19 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | 主引用文献 | Crystal structure of autotaxin and insight into GPCR activation by lipid mediators Nat.Struct.Mol.Biol., 18, 2011
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6Y5M
| Crystal structure of mouse Autotaxin in complex with compound 1a | 分子名称: | (~{E})-3-[4-chloranyl-2-[(5-methyl-1,2,3,4-tetrazol-2-yl)methyl]phenyl]-1-[(2~{R})-4-[(4-fluorophenyl)methyl]-2-methyl-piperazin-1-yl]prop-2-en-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Faller, M, Zink, F. | 登録日 | 2020-02-25 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.011 Å) | 主引用文献 | Development of autotaxin inhibitors: A series of tetrazole cinnamides. Bioorg.Med.Chem.Lett., 31, 2021
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1SMN
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1QAE
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5IJQ
| Crystal structure of autotaxin (ENPP2) re-refined | 分子名称: | 7alpha-hydroxycholesterol, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | 著者 | Hausmann, J, Joosten, R.P, Perrakis, A. | 登録日 | 2016-03-02 | 公開日 | 2016-06-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin. J.Struct.Biol., 195, 2016
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2XR9
| Crystal structure of Autotaxin (ENPP2) | 分子名称: | CALCIUM ION, ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2, IODIDE ION, ... | 著者 | Kamtekar, S, Hausmann, J, Day, J.E, Christodoulou, E, Perrakis, A. | 登録日 | 2010-09-13 | 公開日 | 2011-01-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural basis of substrate discrimination and integrin binding by autotaxin. Nat. Struct. Mol. Biol., 18, 2011
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6NJT
| Mouse endonuclease G mutant - H97A | 分子名称: | CHLORIDE ION, Endonuclease G, mitochondrial, ... | 著者 | Vander Zanden, C.M, Ho, E.N, Czarny, R.S, Robertson, A.B, Ho, P.S. | 登録日 | 2019-01-04 | 公開日 | 2020-01-08 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Structural adaptation of vertebrate endonuclease G for 5-hydroxymethylcytosine recognition and function. Nucleic Acids Res., 48, 2020
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