6LEH
Crystal structure of Autotaxin in complex with an inhibitor
Summary for 6LEH
Entry DOI | 10.2210/pdb6leh/pdb |
Descriptor | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, 1,2-ETHANEDIOL, ethyl 2-[2-(4-chlorophenyl)-7-methyl-5-oxidanylidene-imidazo[1,2-a]pyrimidin-8-yl]ethanoate, ... (12 entities in total) |
Functional Keywords | hydrolase |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 99672.37 |
Authors | Nishimasu, H.,Osamu, N. (deposition date: 2019-11-25, release date: 2020-03-18, Last modification date: 2023-11-22) |
Primary citation | Kawaguchi, M.,Okabe, T.,Okudaira, S.,Hama, K.,Kano, K.,Nishimasu, H.,Nakagawa, H.,Ishitani, R.,Kojima, H.,Nureki, O.,Aoki, J.,Nagano, T. Identification of PotentIn VivoAutotaxin Inhibitors that Bind to Both Hydrophobic Pockets and Channels in the Catalytic Domain. J.Med.Chem., 63:3188-3204, 2020 Cited by PubMed: 32134652DOI: 10.1021/acs.jmedchem.9b01967 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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