6LEH

Crystal structure of Autotaxin in complex with an inhibitor

Summary for 6LEH

Entry DOI	10.2210/pdb6leh/pdb
Descriptor	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, 1,2-ETHANEDIOL, ethyl 2-[2-(4-chlorophenyl)-7-methyl-5-oxidanylidene-imidazo[1,2-a]pyrimidin-8-yl]ethanoate, ... (12 entities in total)
Functional Keywords	hydrolase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	99672.37
Authors	Nishimasu, H.,Osamu, N. (deposition date: 2019-11-25, release date: 2020-03-18, Last modification date: 2023-11-22)
Primary citation	Kawaguchi, M.,Okabe, T.,Okudaira, S.,Hama, K.,Kano, K.,Nishimasu, H.,Nakagawa, H.,Ishitani, R.,Kojima, H.,Nureki, O.,Aoki, J.,Nagano, T. Identification of PotentIn VivoAutotaxin Inhibitors that Bind to Both Hydrophobic Pockets and Channels in the Catalytic Domain. J.Med.Chem., 63:3188-3204, 2020 Cited by PubMed: 32134652 DOI: 10.1021/acs.jmedchem.9b01967 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation