Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6LEH

Crystal structure of Autotaxin in complex with an inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001953	biological_process	negative regulation of cell-matrix adhesion
A	0003676	molecular_function	nucleic acid binding
A	0004528	molecular_function	phosphodiesterase I activity
A	0004551	molecular_function	dinucleotide phosphatase activity
A	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
A	0004630	molecular_function	phospholipase D activity
A	0005044	molecular_function	scavenger receptor activity
A	0005509	molecular_function	calcium ion binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006644	biological_process	phospholipid metabolic process
A	0006935	biological_process	chemotaxis
A	0006955	biological_process	immune response
A	0008270	molecular_function	zinc ion binding
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009395	biological_process	phospholipid catabolic process
A	0010634	biological_process	positive regulation of epithelial cell migration
A	0016042	biological_process	lipid catabolic process
A	0016192	biological_process	vesicle-mediated transport
A	0016787	molecular_function	hydrolase activity
A	0030149	biological_process	sphingolipid catabolic process
A	0030247	molecular_function	polysaccharide binding
A	0030334	biological_process	regulation of cell migration
A	0034638	biological_process	phosphatidylcholine catabolic process
A	0044849	biological_process	estrous cycle
A	0046872	molecular_function	metal ion binding
A	0047391	molecular_function	alkylglycerophosphoethanolamine phosphodiesterase activity
A	0048714	biological_process	positive regulation of oligodendrocyte differentiation
A	0051894	biological_process	positive regulation of focal adhesion assembly
A	0060326	biological_process	cell chemotaxis
A	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
A	2000394	biological_process	positive regulation of lamellipodium morphogenesis

Functional Information from PROSITE/UniProt

site_id	PS00524
Number of Residues	21
Details	SMB_1 Somatomedin B domain (SMB) signature. CrCdnlCksyss.CChDFdelC

Chain	Residue	Details
A	CYS73-CYS93
A	CYS117-CYS137

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	43
Details	Domain: {"description":"SMB 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00350","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	44
Details	Domain: {"description":"SMB 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00350","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	21
Details	Region: {"description":"Required for secretion","evidences":[{"source":"PubMed","id":"19329427","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Motif: {"description":"Cell attachment site","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23688339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23688339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23688339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23688339","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27780639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23688339","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27780639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23688339","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27780639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Site: {"description":"Essential for catalytic activity","evidences":[{"source":"PubMed","id":"19329427","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23688339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23688339","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27780639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)