5LIA

Crystal structure of murine autotaxin in complex with a small molecule inhibitor

Summary for 5LIA

Entry DOI	10.2210/pdb5lia/pdb
Descriptor	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, 1,2-ETHANEDIOL, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
Functional Keywords	lysophospholipase d, autotaxin, enpp2, hydrolase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	98955.72
Authors	Turnbull, A.P.,Shah, P.,Cheasty, A.,Raynham, T.,Pang, L.,Owen, P. (deposition date: 2016-07-14, release date: 2016-11-09, Last modification date: 2024-01-10)
Primary citation	Shah, P.,Cheasty, A.,Foxton, C.,Raynham, T.,Farooq, M.,Gutierrez, I.F.,Lejeune, A.,Pritchard, M.,Turnbull, A.,Pang, L.,Owen, P.,Boyd, S.,Stowell, A.,Jordan, A.,Hamilton, N.M.,Hitchin, J.R.,Stockley, M.,MacDonald, E.,Quesada, M.J.,Trivier, E.,Skeete, J.,Ovaa, H.,Moolenaar, W.H.,Ryder, H. Discovery of potent inhibitors of the lysophospholipase autotaxin. Bioorg. Med. Chem. Lett., 26:5403-5410, 2016 Cited by PubMed: 27780639 DOI: 10.1016/j.bmcl.2016.10.036 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation