5LIA
Crystal structure of murine autotaxin in complex with a small molecule inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004528 | molecular_function | phosphodiesterase I activity |
| A | 0004551 | molecular_function | dinucleotide phosphatase activity |
| A | 0004622 | molecular_function | lysophospholipase activity |
| A | 0004630 | molecular_function | phospholipase D activity |
| A | 0005044 | molecular_function | scavenger receptor activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0006935 | biological_process | chemotaxis |
| A | 0006955 | biological_process | immune response |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009395 | biological_process | phospholipid catabolic process |
| A | 0010634 | biological_process | positive regulation of epithelial cell migration |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016192 | biological_process | vesicle-mediated transport |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| A | 0030149 | biological_process | sphingolipid catabolic process |
| A | 0030247 | molecular_function | polysaccharide binding |
| A | 0030334 | biological_process | regulation of cell migration |
| A | 0034638 | biological_process | phosphatidylcholine catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047391 | molecular_function | alkylglycerophosphoethanolamine phosphodiesterase activity |
| A | 0050731 | biological_process | positive regulation of peptidyl-tyrosine phosphorylation |
| A | 2000394 | biological_process | positive regulation of lamellipodium morphogenesis |
Functional Information from PROSITE/UniProt
| site_id | PS00524 |
| Number of Residues | 21 |
| Details | SMB_1 Somatomedin B domain (SMB) signature. CrCdnlCksyss.CChDFdelC |
| Chain | Residue | Details |
| A | CYS73-CYS93 | |
| A | CYS117-CYS137 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000305|PubMed:21240269 |
| Chain | Residue | Details |
| A | THR209 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH |
| Chain | Residue | Details |
| A | ASP171 | |
| A | THR209 | |
| A | HIS359 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21240269, ECO:0007744|PDB:3NKN |
| Chain | Residue | Details |
| A | ASN230 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH, ECO:0007744|PDB:5LIA |
| Chain | Residue | Details |
| A | ASP311 | |
| A | HIS315 | |
| A | HIS474 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH |
| Chain | Residue | Details |
| A | ASP358 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0000269|PubMed:27780639, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH, ECO:0007744|PDB:5LIA |
| Chain | Residue | Details |
| A | ASN739 | |
| A | ASP743 | |
| A | GLU745 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0000269|PubMed:27780639, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH, ECO:0007744|PDB:5LIA |
| Chain | Residue | Details |
| A | LEU741 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0000269|PubMed:27780639, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5INH, ECO:0007744|PDB:5LIA |
| Chain | Residue | Details |
| A | GLU747 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | SITE: Essential for catalytic activity => ECO:0000269|PubMed:19329427 |
| Chain | Residue | Details |
| A | HIS852 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5INH |
| Chain | Residue | Details |
| A | ASN53 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0000269|PubMed:27780639, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH, ECO:0007744|PDB:5LIA |
| Chain | Residue | Details |
| A | ASN410 | |
| A | ASN524 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASP806 |
