PDB: 149 resultsInfo pagesStatus searchChemie searchBIRD

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6OYG	Crystal structure of H62F mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2019-05-14 Release date: 2020-04-22 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel. Cell Chem Biol, 27, 2020
6OY8	Crystal structure of Y99G mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2019-05-14 Release date: 2020-04-22 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel. Cell Chem Biol, 27, 2020
1FIM	MACROPHAGE MIGRATION INHIBITORY FACTOR Descriptor: MACROPHAGE MIGRATION INHIBITORY FACTOR Authors: Suzuki, M, Sugimoto, H, Nakagawa, A, Tanaka, I. Deposit date: 1996-01-31 Release date: 1996-07-11 Last modified: 2022-12-21 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of the macrophage migration inhibitory factor from rat liver. Nat.Struct.Biol., 3, 1996
8CA0	Macrophage inhibitory factor (MIF) in complex with small molecule PAV174 Descriptor: 1-ethyl-9-methyl-3,7-dipyrrolidin-1-yl-phenothiazine, Macrophage migration inhibitory factor Authors: Mueller, A, Torres, F, Roland, R, Korth, C. Deposit date: 2023-01-24 Release date: 2024-02-07 Method: SOLUTION NMR Cite: Oxidized MIF is a drug target at the molecular intersection between immune activation and tau cellular pathology To Be Published
5J7P	Macrophage Migration Inhibitory Factor bound to Covalent Inhibitor RDR03785 Descriptor: 6-{[4-(trifluoromethyl)phenyl]methyl}-2H-1,3-benzodioxol-5-ol, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Robertson, M.J, Jorgensen, W.L. Deposit date: 2016-04-06 Release date: 2016-05-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Irregularities in enzyme assays: The case of macrophage migration inhibitory factor. Bioorg.Med.Chem.Lett., 26, 2016
1GCZ	MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) COMPLEXED WITH INHIBITOR. Descriptor: 7-HYDROXY-2-OXO-CHROMENE-3-CARBOXYLIC ACID ETHYL ESTER, CITRIC ACID, MACROPHAGE MIGRATION INHIBITORY FACTOR, ... Authors: Katayama, N, Kurihara, H. Deposit date: 2000-08-24 Release date: 2001-02-21 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography. J.Med.Chem., 44, 2001
1GD0	HUMAN MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) Descriptor: CITRIC ACID, MACROPHAGE MIGRATION INHIBITORY FACTOR, SULFATE ION Authors: Kurihara, H, Katayama, N. Deposit date: 2000-08-24 Release date: 2001-02-21 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography. J.Med.Chem., 44, 2001
6PEG	MIF with a allosteric inhibitor Descriptor: 4-amino-5-hydroxy-6-[(E)-(3-{[3-(2-methylpropanoyl)pyrazolo[1,5-a]pyridin-2-yl]methyl}phenyl)diazenyl]naphthalene-1,3-disulfonic acid, ACETATE ION, GLYCEROL, ... Authors: Asojo, O.A. Deposit date: 2019-06-20 Release date: 2019-11-27 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Inhibition of Macrophage Migration Inhibitory Factor by a Chimera of Two Allosteric Binders. Acs Med.Chem.Lett., 11, 2020
8DBB	Crystal structure of DDT with the selective inhibitor 2,5-Pyridinedicarboxylic Acid Descriptor: CITRIC ACID, D-dopachrome decarboxylase, pyridine-2,5-dicarboxylic acid Authors: Parkins, A, Banumathi, S, Pantouris, G. Deposit date: 2022-06-14 Release date: 2023-03-08 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.3 Å) Cite: 2,5-Pyridinedicarboxylic acid is a bioactive and highly selective inhibitor of D-dopachrome tautomerase. Structure, 31, 2023
4DH4	Macrophage migration inhibitory factor Toxoplasma gondii Descriptor: MIF, SULFATE ION Authors: Richardson, J.M. Deposit date: 2012-01-27 Release date: 2012-11-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Biochemical and Immunological Characterization of Toxoplasma gondii Macrophage Migration Inhibitory Factor. J.Biol.Chem., 288, 2013
8DQA	Structure of A. thaliana MIF/D-DT-like protein-3 (MDL3) Descriptor: LS1-like protein Authors: Manjula, R, Basquin, J, Lolis, E. Deposit date: 2022-07-18 Release date: 2023-07-26 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of A. thaliana MIF/D-DT-like protein-3 (MDL3) To Be Published
8DQ6	Structure of A. thaliana MIF/D-DT-like protein-1 (MDL1) Descriptor: CALCIUM ION, MIF/D-DT-like protein-1 Authors: Manjula, R, Basquin, J, Lolis, E. Deposit date: 2022-07-18 Release date: 2023-07-26 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Structure of A. thaliana MIF/D-DT-like protein-1 (AtMDL1) To Be Published
1GIF	HUMAN GLYCOSYLATION-INHIBITING FACTOR Descriptor: GLYCOSYLATION-INHIBITING FACTOR Authors: Kato, Y, Kuroki, R. Deposit date: 1996-02-27 Release date: 1997-03-12 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The crystal structure of human glycosylation-inhibiting factor is a trimeric barrel with three 6-stranded beta-sheets. Proc.Natl.Acad.Sci.USA, 93, 1996
1HFO	The Structure of the Macrophage Migration Inhibitory Factor from Trichinella Spiralis. Descriptor: MIGRATION INHIBITORY FACTOR Authors: Roe, S.M, Meyer, D.J. Deposit date: 2000-12-07 Release date: 2001-08-30 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Macrophage Migration Inhibitory Factor of the Parasitic Nematode Trichinella Spiralis Biochem.J., 357, 2001
4EUI	Crystal Structure of MIF L46F mutant Descriptor: Macrophage migration inhibitory factor, SULFATE ION Authors: Ashrafi, A, Pojer, F, Lashuel, H. Deposit date: 2012-04-25 Release date: 2012-10-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket. Plos One, 7, 2012
4ETG	Crystal Structure of MIF L46G mutant Descriptor: Macrophage migration inhibitory factor, SULFATE ION Authors: Ashrafi, A, Pojer, F, Lashuel, H. Deposit date: 2012-04-24 Release date: 2012-10-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket. Plos One, 7, 2012
4EVG	Crystal Structure of MIF L46A mutant Descriptor: Macrophage migration inhibitory factor, SULFATE ION Authors: Ashrafi, A, Pojer, F, Lashuel, H. Deposit date: 2012-04-26 Release date: 2012-10-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket. Plos One, 7, 2012
4F2K	Macrophage Migration Inhibitory Factor covalently complexed with phenethylisothiocyanate Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, N-(2-phenylethyl)thioformamide, ... Authors: Tyndall, J.D.A, Bernhagen, J, Hampton, M.B, Wilbanks, S.M, Rutledge, M.T. Deposit date: 2012-05-08 Release date: 2012-06-06 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate Acta Crystallogr.,Sect.F, 68, 2012
3SMB	Phenethylisothiocyanate Covalently Bound to Macrophage Migration Inhibitory Factor (MIF) Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, N-(2-phenylethyl)thioformamide, ... Authors: Crichlow, G.V, Lolis, E.J. Deposit date: 2011-06-27 Release date: 2012-10-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural interactions dictate the kinetics of macrophage migration inhibitory factor inhibition by different cancer-preventive isothiocyanates. Biochemistry, 51, 2012
3T5S	Structure of macrophage migration inhibitory factor from Giardia lamblia Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, SULFATE ION Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-07-28 Release date: 2011-08-24 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia. J.Struct.Funct.Genom., 14, 2013
3U18	Chicago Sky Blue 6B, A Novel Inhibitor for Macrophage Migration Inhibitory Factor Descriptor: 1,2-ETHANEDIOL, 6,6'-[(3,3'-dimethoxybiphenyl-4,4'-diyl)di(E)diazene-2,1-diyl]bis(4-amino-5-hydroxynaphthalene-1,3-disulfonic acid), GLYCEROL, ... Authors: Asojo, O.A. Deposit date: 2011-09-29 Release date: 2012-07-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A Novel Allosteric Inhibitor of Macrophage Migration Inhibitory Factor (MIF). J.Biol.Chem., 287, 2012
5UMK	Crystal structure of H62Y mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2017-01-27 Release date: 2018-02-07 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel. Cell Chem Biol, 27, 2020
5UZY	Crystal structure of N97A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2017-02-27 Release date: 2018-02-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74. Angew. Chem. Int. Ed. Engl., 57, 2018
5V70	Crystal structure of N102A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2017-03-17 Release date: 2018-03-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Crystal structure of N102A mutant of human macrophage migration inhibitory factor To Be Published
5UMJ	Crystal structure of H62A mutant of human macrophage migration inhibitory factor Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION Authors: Pantouris, G, Lolis, E. Deposit date: 2017-01-27 Release date: 2018-02-07 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel. Cell Chem Biol, 27, 2020

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