1FIM

MACROPHAGE MIGRATION INHIBITORY FACTOR

Summary for 1FIM

• Entry DOI: 10.2210/pdb1fim/pdb
• Descriptor: MACROPHAGE MIGRATION INHIBITORY FACTOR (1 entity in total)
• Functional Keywords: macrophage, inflammatory response, cytokine
• Biological source: Rattus norvegicus (Norway rat)
• Cellular location: Secreted : P30904
• Total number of polymer chains: 1
• Total formula weight: 12282.66

Authors

Suzuki, M.,Sugimoto, H.,Nakagawa, A.,Tanaka, I. (deposition date: 1996-01-31, release date: 1996-07-11, Last modification date: 2024-11-13)

Primary citation

Suzuki, M.,Sugimoto, H.,Nakagawa, A.,Tanaka, I.,Nishihira, J.,Sakai, M.
Crystal structure of the macrophage migration inhibitory factor from rat liver.
Nat.Struct.Biol., 3:259-266, 1996

PubMed Abstract: The tertiary structure of the macrophage migration inhibitory factor (MIF) from rat liver (12,300 Mr) is presented at 2.2 A resolution. Each monomer consists of two beta/alpha/beta motifs aligned in quasi two-fold symmetry, comprising a domain consisting of a four-stranded mixed beta-sheet and two antiparallel alpha-helices. The protein exists as a trimer in the crystal. An extra beta-strand that is almost perpendicular to the other beta-strands joins to the beta-sheet of the neighbouring monomer in the trimer. Unexpected similarities were detected between MIF and two kinds of isomerase.

PubMed: 8605628
DOI: 10.1038/nsb0396-259

Experimental method

X-RAY DIFFRACTION (2.2 Å)