8TI1
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8TI2
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8I5M
| Rat Kir4.1 in complex with PIP2 | 分子名称: | ATP-sensitive inward rectifier potassium channel 10, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Zhao, C, Guo, J. | 登録日 | 2023-01-26 | 公開日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Pharmacological inhibition of astrocytic Kir4.1 channel evokes rapid-onset antidepressant responses To Be Published
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8I5N
| Rat Kir4.1 in complex with PIP2 and Lys05 | 分子名称: | ATP-sensitive inward rectifier potassium channel 10, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Zhao, C, Guo, J. | 登録日 | 2023-01-26 | 公開日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Pharmacological inhibition of astrocytic Kir4.1 channel evokes rapid-onset antidepressant responses To Be Published
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7UQR
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7ZDZ
| Cryo-EM structure of the human inward-rectifier potassium 2.1 channel (Kir2.1) | 分子名称: | Inward rectifier potassium channel 2, POTASSIUM ION, STRONTIUM ION | 著者 | Fernandes, C.A.H, Venien-Bryan, C, Fagnen, C, Zuniga, D. | 登録日 | 2022-03-30 | 公開日 | 2022-09-28 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Cryo-electron microscopy unveils unique structural features of the human Kir2.1 channel. Sci Adv, 8, 2022
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7UAA
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7U7M
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7U6Y
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7U2X
| Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of carbamazepine and ATP with Kir6.2-CTD in the down conformation | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Shyng, S.L, Sung, M.W, Driggers, C.M. | 登録日 | 2022-02-25 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
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7U24
| Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and glibenclamide with Kir6.2-CTD in the up conformation | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... | 著者 | Shyng, S.L, Sung, M.W, Driggers, C.M. | 登録日 | 2022-02-23 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
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7U1S
| Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with SUR1-out conformation | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Shyng, S.L, Sung, M.W, Driggers, C.M. | 登録日 | 2022-02-22 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
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7U1E
| CryoEM structure of the pancreatic ATP-sensitive potassium channel bound to ATP with Kir6.2-CTD in the down conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Shyng, S.L, Sung, M.W, Driggers, C.M. | 登録日 | 2022-02-21 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (4.52 Å) | 主引用文献 | Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
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7U1Q
| Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with SUR1-in conformation | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Shyng, S.L, Sung, M.W, Driggers, C.M. | 登録日 | 2022-02-21 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
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7TYT
| Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with Kir6.2-CTD in the down conformation | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Shyng, S.L, Sung, M.W, Driggers, C.M. | 登録日 | 2022-02-14 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
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7TYS
| Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with Kir6.2-CTD in the up conformation | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Shyng, S.L, Sung, M.W, Driggers, C.M. | 登録日 | 2022-02-14 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
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7W4O
| The structure of KATP H175K mutant in pre-open state | 分子名称: | 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, L, Wang, M. | 登録日 | 2021-11-28 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides. Nat Commun, 13, 2022
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7W4P
| The structure of KATP H175K mutant in closed state | 分子名称: | 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, L, Wang, M. | 登録日 | 2021-11-28 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides. Nat Commun, 13, 2022
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7S5Z
| Human KATP channel in open conformation, focused on Kir and one SUR, position 3 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2021-09-12 | 公開日 | 2021-12-01 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
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7S5T
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7S61
| Human KATP channel in open conformation, focused on Kir and one SUR, position 5 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2021-09-12 | 公開日 | 2021-12-01 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
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7S60
| Human KATP channel in open conformation, focused on Kir and one SUR, position 4 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2021-09-12 | 公開日 | 2021-12-01 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
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7S5Y
| Human KATP channel in open conformation, focused on Kir and one SUR, position 2 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2021-09-12 | 公開日 | 2021-12-01 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
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7S5X
| Human KATP channel in open conformation, focused on Kir and one SUR, position 1 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2021-09-12 | 公開日 | 2021-12-01 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MJP
| Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Sung, M.W, Shyng, S.L. | 登録日 | 2021-04-20 | 公開日 | 2021-10-13 | 最終更新日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides. Proc.Natl.Acad.Sci.USA, 118, 2021
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