7TYT

Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with Kir6.2-CTD in the down conformation

Summary for 7TYT

Entry DOI	10.2210/pdb7tyt/pdb
EMDB information	20528 26194
Descriptor	ATP-sensitive inward rectifier potassium channel 11, ATP-binding cassette sub-family C member 8, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	katp channel, sur1, kir6.2, repaglinide, rpg, sulfonylurea receptor, potassium transport, membrane protein
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	5
Total formula weight	365221.38
Authors	Shyng, S.L.,Sung, M.W.,Driggers, C.M. (deposition date: 2022-02-14, release date: 2022-08-31, Last modification date: 2022-09-14)
Primary citation	Sung, M.W.,Driggers, C.M.,Mostofian, B.,Russo, J.D.,Patton, B.L.,Zuckerman, D.M.,Shyng, S.L. Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434:167789-167789, 2022 Cited by PubMed: 35964676 DOI: 10.1016/j.jmb.2022.167789 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation