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3SYQ
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Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) R201A mutant in complex with PIP2
分子名称: G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Whorton, M.R, MacKinnon, R.
登録日2011-07-18
公開日2011-10-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.44 Å)
主引用文献Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium.
Cell(Cambridge,Mass.), 147, 2011
4KFM
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Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with the beta-gamma G protein subunits
分子名称: DODECYL-BETA-D-MALTOSIDE, G protein-activated inward rectifier potassium channel 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Whorton, M.R, MacKinnon, R.
登録日2013-04-27
公開日2013-06-12
最終更新日2013-09-11
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献X-ray structure of the mammalian GIRK2-beta gamma G-protein complex.
Nature, 498, 2013
8TI1
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Cryo-EM structure of a SUR1/Kir6.2-Q52R ATP-sensitive potassium channel in the presence of PIP2 in the open conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ATP-sensitive inward rectifier potassium channel 11, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ...
著者Driggers, C.M, Shyng, S.-L.
登録日2023-07-18
公開日2024-04-03
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structure of an open K ATP channel reveals tandem PIP 2 binding sites mediating the Kir6.2 and SUR1 regulatory interface.
Nat Commun, 15, 2024
8TI2
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Cryo-EM structure of a SUR1/Kir6.2-Q52R ATP-sensitive potassium channel in the presence of PIP2 in the open conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ATP-sensitive inward rectifier potassium channel 11, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ...
著者Driggers, C.M, Shyng, S.-L.
登録日2023-07-18
公開日2024-04-03
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Structure of an open K ATP channel reveals tandem PIP 2 binding sites mediating the Kir6.2 and SUR1 regulatory interface.
Nat Commun, 15, 2024
5TWV
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Cryo-EM structure of the pancreatic ATP-sensitive K+ channel SUR1/Kir6.2 in the presence of ATP and glibenclamide
分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11
著者Martin, G.M, Yoshioka, C, Chen, J.Z, Shyng, S.L.
登録日2016-11-14
公開日2017-01-25
最終更新日2019-12-25
実験手法ELECTRON MICROSCOPY (6.3 Å)
主引用文献Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating.
Elife, 6, 2017
6PZA
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Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and glibenclamide
分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
著者Shyng, S.L, Yoshioka, C, Martin, G.M, Sung, M.W.
登録日2019-07-31
公開日2019-08-14
最終更新日2020-10-07
実験手法ELECTRON MICROSCOPY (3.74 Å)
主引用文献Mechanism of pharmacochaperoning in a mammalian K ATP channel revealed by cryo-EM.
Elife, 8, 2019
6PZ9
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Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and repaglinide
分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11, ...
著者Shyng, S.L, Yoshioka, C, Martin, G.M, Sung, M.W.
登録日2019-07-31
公開日2019-08-14
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.65 Å)
主引用文献Mechanism of pharmacochaperoning in a mammalian K ATP channel revealed by cryo-EM.
Elife, 8, 2019
5WUA
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Structure of a Pancreatic ATP-sensitive Potassium Channel
分子名称: ATP-sensitive inward rectifier potassium channel 11,superfolder GFP, SUR1
著者Li, N, Wu, J.-X, Chen, L, Gao, N.
登録日2016-12-16
公開日2017-01-25
実験手法ELECTRON MICROSCOPY (5.6 Å)
主引用文献Structure of a Pancreatic ATP-Sensitive Potassium Channel
Cell, 168, 2017
7MJP
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Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Sung, M.W, Shyng, S.L.
登録日2021-04-20
公開日2021-10-13
最終更新日2022-10-26
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MJQ
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Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ATP-sensitive inward rectifier potassium channel 8, ...
著者Sung, M.W, Shyng, S.L.
登録日2021-04-20
公開日2021-10-13
最終更新日2022-10-26
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MJO
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Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 1
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ...
著者Sung, M.W, Shyng, S.L.
登録日2021-04-20
公開日2021-10-13
最終更新日2022-10-26
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MIT
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Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 1
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ...
著者Sung, M.W, Shyng, S.L.
登録日2021-04-17
公開日2021-10-13
最終更新日2023-08-16
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
6JB1
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Structure of pancreatic ATP-sensitive potassium channel bound with repaglinide and ATPgammaS at 3.3A resolution
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y.
登録日2019-01-25
公開日2019-05-22
最終更新日2021-09-29
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel.
Cell Rep, 27, 2019
7S5Z
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Human KATP channel in open conformation, focused on Kir and one SUR, position 3
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
著者Zhao, C, MacKinnon, R.
登録日2021-09-12
公開日2021-12-01
最終更新日2021-12-08
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
7S61
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Human KATP channel in open conformation, focused on Kir and one SUR, position 5
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
著者Zhao, C, MacKinnon, R.
登録日2021-09-12
公開日2021-12-01
最終更新日2021-12-08
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
7S60
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Human KATP channel in open conformation, focused on Kir and one SUR, position 4
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
著者Zhao, C, MacKinnon, R.
登録日2021-09-12
公開日2021-12-01
最終更新日2021-12-08
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
7S5Y
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Human KATP channel in open conformation, focused on Kir and one SUR, position 2
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
著者Zhao, C, MacKinnon, R.
登録日2021-09-12
公開日2021-12-01
最終更新日2021-12-08
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
7S5X
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BU of 7s5x by Molmil
Human KATP channel in open conformation, focused on Kir and one SUR, position 1
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
著者Zhao, C, MacKinnon, R.
登録日2021-09-12
公開日2021-12-01
最終更新日2021-12-08
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
5YKF
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BU of 5ykf by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (3D class1 at 4.33A)
分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-10-14
公開日2018-04-18
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (4.33 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YKG
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Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (Class2 at 4.57A)
分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-10-14
公開日2018-04-18
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (4.57 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YKE
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Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (focused refinement on TM at 4.11A)
分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11
著者Chen, L, Wu, J.X.
登録日2017-10-14
公開日2018-04-18
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (4.11 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YWC
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Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class1 at 4.3A)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YW9
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Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (class1 5.0A)
分子名称: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (5 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YWB
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Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class2 at 5.2A)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-30
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (5.2 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YW8
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Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (all particles at 4.4A)
分子名称: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018

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