PDB: 75 件ウェブページステータス検索Chemie searchBIRD

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4EFJ	Crystal structure of I-GzeII LAGLIDADG homing endonuclease in complex with DNA target site 分子名称: CALCIUM ION, DNA target site bottom strand, DNA target site top strand, ... 著者 Kulshina, N. 登録日 2012-03-29 公開日 2012-05-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of I-GzeMII LAGLIDADG homing endonuclease in complex with DNA target site To be Published
3KO2	I-MsoI re-designed for altered DNA cleavage specificity (-7C) 分子名称: 5'-D(*CP*GP*GP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*GP*TP*CP*TP*GP*C)-3', 5'-D(*GP*CP*AP*GP*AP*CP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*CP*CP*G)-3', CALCIUM ION, ... 著者 Taylor, G.K, Stoddard, B.L. 登録日 2009-11-13 公開日 2010-05-19 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs. Nucleic Acids Res., 38, 2010
2QOJ	Coevolution of a homing endonuclease and its host target sequence 分子名称: I-AniI DNA target seq1, I-AniI DNA target seq2, LAGLIDADG endonuclease, ... 著者 Scalley-Kim, M, McConnell Smith, A, Stoddard, B.L. 登録日 2007-07-20 公開日 2008-11-11 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Coevolution of a homing endonuclease and its host target sequence. J.Mol.Biol., 372, 2007
2O7M	The C-terminal loop of the homing endonuclease I-CreI is essential for DNA binding and cleavage. Identification of a novel site for specificity engineering in the I-CreI scaffold 分子名称: DNA endonuclease I-CreI 著者 Prieto, J, Redondo, P, Padro, D, Blanco, F.J, Paques, F, Montoya, G. 登録日 2006-12-11 公開日 2007-10-23 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The C-terminal loop of the homing endonuclease I-CreI is essential for site recognition, DNA binding and cleavage Nucleic Acids Res., 35, 2007
4AAE	Crystal structure of the mutant D75N I-CreI in complex with an altered target (The four central bases, 2NN region, are composed by AGCG from 5' to 3') 分子名称: 24MER DNA, DNA ENDONUCLEASE I-CREI 著者 Molina, R, Redondo, P, Stella, S, Marenchino, M, D'Abramo, M, Gervasio, F.L, Epinat, J.C, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G. 登録日 2011-12-01 公開日 2012-05-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage. Nucleic Acids Res., 40, 2012
1AF5	GROUP I MOBILE INTRON ENDONUCLEASE 分子名称: I-CREI 著者 Heath, P.J, Stephens, K.M, Monnat Junior, R.J, Stoddard, B.L. 登録日 1997-03-21 公開日 1997-07-23 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The structure of I-Crel, a group I intron-encoded homing endonuclease. Nat.Struct.Biol., 4, 1997
4LOX	Crystal structure of the I-SmaMI LAGLIDADG homing endonuclease bound to cleaved DNA 分子名称: DNA (5'-D(*CP*GP*TP*AP*CP*AP*CP*CP*TP*GP*AP*TP*AP*A)-3'), DNA (5'-D(*GP*GP*TP*AP*TP*CP*CP*TP*CP*CP*AP*TP*TP*AP*T)-3'), DNA (5'-D(P*CP*AP*GP*GP*TP*GP*TP*AP*CP*G)-3'), ... 著者 Chik, J, Shen, B, Stoddard, B. 登録日 2013-07-14 公開日 2014-09-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Crystal structure of a LAGLIDADG endonuclease from the Sordaria Macrospore. To be Published
4LQ0	Crystal structure of the I-LtrWI LAGLIDADG homing endonuclease bound to target DNA. 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Chik, J, Shen, B, Stoddard, B. 登録日 2013-07-16 公開日 2014-07-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Structural Comparisons of LAGLIDADG Homing Endonucleases. To be Published
1BP7	GROUP I MOBILE INTRON ENDONUCLEASE I-CREI COMPLEXED WITH HOMING SITE DNA 分子名称: CALCIUM ION, DNA (5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP* GP*C)-3'), DNA (5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP* CP*G)-3'), ... 著者 Jurica, M.S, Monnat Junior, R.J, Stoddard, B.L. 登録日 1998-08-13 公開日 1999-01-06 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 DNA recognition and cleavage by the LAGLIDADG homing endonuclease I-CreI. Mol.Cell, 2, 1998
3R7P	The crystal structure of I-LtrI 分子名称: DNA (5'-D(*CP*AP*AP*AP*TP*GP*CP*TP*CP*CP*TP*AP*TP*AP*C)-3'), DNA (5'-D(*GP*GP*TP*CP*TP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*GP*CP*AP*TP*TP*TP*G)-3'), ... 著者 Mak, A.N.S, Takeuchi, R, Edgell, D.R, Stoddard, B.L. 登録日 2011-03-22 公開日 2011-07-20 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.704 Å) 主引用文献 Tapping natural reservoirs of homing endonucleases for targeted gene modification. Proc.Natl.Acad.Sci.USA, 108, 2011
2I3Q	Q44V mutant of Homing Endonuclease I-CreI 分子名称: 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*AP*CP*TP*CP*AP*CP*GP*TP*CP*GP*TP*TP*TP*TP*GP*C)-3', 5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*AP*CP*GP*TP*GP*AP*GP*TP*CP*AP*GP*TP*TP*TP*CP*G)-3', CALCIUM ION, ... 著者 Rosen, L, Sussman, D. 登録日 2006-08-20 公開日 2006-09-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Homing endonuclease I-CreI derivatives with novel DNA target specificities. Nucleic Acids Res., 34, 2006
1G9Y	HOMING ENDONUCLEASE I-CREI / DNA SUBSTRATE COMPLEX WITH CALCIUM 分子名称: 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*C)-3', 5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP*CP*G)-3', CALCIUM ION, ... 著者 Chevalier, B, Monnat, R.J, Stoddard, B.L. 登録日 2000-11-28 公開日 2001-04-02 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites. Nat.Struct.Biol., 8, 2001
1G9Z	LAGLIDADG HOMING ENDONUCLEASE I-CREI / DNA PRODUCT COMPLEX WITH MAGNESIUM 分子名称: 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*C)-3', 5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*A)-3', 5'-D(P*GP*AP*CP*AP*GP*TP*TP*TP*CP*G)-3', ... 著者 Chevalier, B, Monnat, R.J, Stoddard, B.L. 登録日 2000-11-28 公開日 2001-04-02 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites. Nat.Struct.Biol., 8, 2001
3QQY	Crystal structure of a novel LAGLIDADG homing endonuclease, I-OnuI (from Ophiostoma novo-ulmi subsp. americana) 分子名称: DNA (26-MER), MAGNESIUM ION, Ribosomal protein 3/homing endonuclease-like protein fusion 著者 Takeuchi, R, Stoddard, B.L. 登録日 2011-02-16 公開日 2011-07-20 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.401 Å) 主引用文献 Tapping natural reservoirs of homing endonucleases for targeted gene modification. Proc.Natl.Acad.Sci.USA, 108, 2011
2I3P	K28R mutant of Homing Endonuclease I-CreI 分子名称: 5'-D(*CP*GP*AP*AP*AP*TP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*AP*TP*TP*TP*GP*C)-3', 5'-D(*GP*CP*AP*AP*AP*TP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*AP*TP*TP*TP*CP*G)-3', CALCIUM ION, ... 著者 Sussman, D, Rosen, L. 登録日 2006-08-20 公開日 2006-09-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Homing endonuclease I-CreI derivatives with novel DNA target specificities. Nucleic Acids Res., 34, 2006
3E54	Archaeal Intron-encoded Homing Endonuclease I-Vdi141I Complexed With DNA 分子名称: DNA (5'-D(*DCP*DTP*DGP*DAP*DCP*DTP*DCP*DTP*DCP*DTP*DTP*DAP*DA)-3'), DNA (5'-D(*DTP*DTP*DGP*DGP*DCP*DTP*DAP*DCP*DCP*DTP*DTP*DAP*DA)-3'), DNA (5'-D(P*DGP*DAP*DGP*DAP*DGP*DTP*DCP*DAP*DG)-3'), ... 著者 Nomura, N, Nomura, Y, Sussman, D, Stoddard, B.L. 登録日 2008-08-13 公開日 2008-12-30 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Recognition of a common rDNA target site in archaea and eukarya by analogous LAGLIDADG and His-Cys box homing endonucleases Nucleic Acids Res., 36, 2008
3FD2	Crystal structure of mMsoI/DNA complex with calcium 分子名称: 5'-D(*CP*GP*GP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*CP*TP*GP*C)-3', 5'-D(*GP*CP*AP*GP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*CP*CP*G)-3', CALCIUM ION, ... 著者 Li, H, Monnat, R.J. 登録日 2008-11-24 公開日 2009-06-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins. Nucleic Acids Res., 37, 2009
4YIT	Crystal Structure of LAGLIDADG Meganuclease I-AabMI Bound to Uncleaved DNA 分子名称: CALCIUM ION, DNA (25-MER), DNA (25MER), ... 著者 Hallinan, J.P, Stoddard, B.L. 登録日 2015-03-02 公開日 2016-03-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.24 Å) 主引用文献 Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure, 24, 2016
4YIS	Crystal Structure of LAGLIDADG Meganuclease I-CpaMI Bound to Uncleaved DNA 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DNA (28-MER), ... 著者 Hallinan, J.P, Kaiser, B.K, Stoddard, B.L. 登録日 2015-03-02 公開日 2016-03-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure, 24, 2016
4YHX	Crystal Structure of LAGLIDADG Meganuclease I-GpeMI Bound to Uncleaved DNA 分子名称: CALCIUM ION, DNA (27-MER), Ribosomal protein 3/homing endonuclease-like fusion protein 著者 Hallinan, J.P, Kaiser, B.K, Stoddard, B.L. 登録日 2015-02-27 公開日 2016-03-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure, 24, 2016
3EH8	Crystal structure of Y2 I-AniI variant (F13Y/S111Y)/DNA complex with calcium 分子名称: 31-MER, CALCIUM ION, Intron-encoded DNA endonuclease I-AniI 著者 Takeuchi, R, Stoddard, B.L. 登録日 2008-09-11 公開日 2009-01-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation. Nucleic Acids Res., 37, 2009
2AB5	bI3 LAGLIDADG Maturase 分子名称: SULFATE ION, mRNA maturase 著者 Longo, A, Leonard, C.W, Bassi, G.S, Berndt, D, Krahn, J.M, Hall, T.M, Weeks, K.M. 登録日 2005-07-14 公開日 2005-08-30 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Evolution from DNA to RNA recognition by the bI3 LAGLIDADG maturase Nat.Struct.Mol.Biol., 12, 2005
2EX5	Group I Intron-encoded Homing Endonuclease I-CeuI Complexed With DNA 分子名称: CALCIUM ION, DNA endonuclease I-CeuI, I-CeuI DNA target site, ... 著者 Spiegel, P.C, Stoddard, B.L. 登録日 2005-11-07 公開日 2006-05-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The structure of I-CeuI homing endonuclease: Evolving asymmetric DNA recognition from a symmetric protein scaffold. Structure, 14, 2006
2FLD	I-MsoI Re-Designed for Altered DNA Cleavage Specificity 分子名称: 5'-D(*CP*GP*GP*AP*AP*CP*GP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*CP*TP*TP*CP*TP*GP*C)-3', 5'-D(*GP*CP*AP*GP*AP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*CP*GP*TP*TP*CP*CP*G)-3', CALCIUM ION, ... 著者 Ashworth, J, Duarte, C.M, Havranek, J.J, Sussman, D, Monnat, R.J, Stoddard, B.L, Baker, D. 登録日 2006-01-05 公開日 2006-06-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Computational redesign of endonuclease DNA binding and cleavage specificity. Nature, 441, 2006
2VBL	Molecular basis of human XPC gene recognition and cleavage by engineered homing endonuclease heterodimers 分子名称: 5'-D(*DA*DA*DA*DA*DG*DG*DC*DA*DG*DAP)-3', 5'-D(*DA*DG*DG*DA*DT*DC*DC*DT*DA*DAP)-3', 5'-D(*DT*DC*DT*DG*DC*DC*DT*DT*DT*DT*DT*DT *DGP*DAP)-3', ... 著者 Redondo, P, Prieto, J, Munoz, I.G, Alibes, A, Stricher, F, Serrano, L, Arnould, S, Perez, C, Cabaniols, J.P, Duchateau, P, Paques, F, Blanco, F.J, Montoya, G. 登録日 2007-09-14 公開日 2008-10-28 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases Nature, 456, 2008

 

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