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4YSI
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BU of 4ysi by Molmil
Structure of USP7 with a novel viral protein
分子名称: GLYCEROL, SER-PRO-GLY-GLU-GLY-PRO-SER-GLY, Ubiquitin carboxyl-terminal hydrolase 7
著者Chavoshi, S, Saridakis, V.
登録日2015-03-17
公開日2016-02-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.02 Å)
主引用文献Structure of USP7 with a novel viral protein
J.Biol.Chem., 2016
7D3D
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BU of 7d3d by Molmil
Crystal structure of SPOP bound with a peptide
分子名称: GLU-VAL-SER-ILE-ILE-GLN-GLY-ALA-ASP-SER-THR-THR, GLYCEROL, Speckle-type POZ protein
著者Yang, C.-G, Gan, J.H.
登録日2020-09-18
公開日2020-11-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献A peptide binder of E3 ligase adaptor SPOP disrupts oncogenic SPOP-protein interactions in kidney cancer cells.
Chin.J.Chem., 39, 2021
2XXN
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BU of 2xxn by Molmil
Structure of the vIRF4-HAUSP TRAF domain complex
分子名称: K10, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7
著者Choi, W.C, Hwang, J, Kim, M.H.
登録日2010-11-11
公開日2011-11-09
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Bilateral Inhibition of Hausp Deubiquitinase by a Viral Interferon Regulatory Factor Protein
Nat.Struct.Mol.Biol., 18, 2011
4O1V
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BU of 4o1v by Molmil
SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer
分子名称: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Speckle-type POZ protein
著者Calabrese, M.F, Watson, E.R, Schulman, B.A.
登録日2013-12-16
公開日2014-04-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer.
Cancer Cell, 25, 2014
3MQR
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BU of 3mqr by Molmil
Crystal Structure of the USP7:HdmX(AHSS) complex
分子名称: HdmX Peptide, Ubiquitin carboxyl-terminal hydrolase 7
著者Saridakis, V.
登録日2010-04-28
公開日2010-08-25
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structure Of USP7
To be Published
3MQS
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BU of 3mqs by Molmil
Crystal Structure of the USP7:Hdm2(PSTS) complex
分子名称: Hdm2 peptide, Ubiquitin carboxyl-terminal hydrolase 7
著者Saridakis, V.
登録日2010-04-28
公開日2010-08-25
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of USP7
To be Published
6F8G
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BU of 6f8g by Molmil
Co-crystal structure of SPOP MATH domain and hamster Pdx1 fragment
分子名称: Pancreas/duodenum homeobox protein 1, Speckle-type POZ protein
著者Ostertag, M.S, Popowicz, G.M, Sattler, M.
登録日2017-12-13
公開日2018-11-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation.
Structure, 27, 2019
6F8F
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BU of 6f8f by Molmil
Co-crystal structure of SPOP MATH domain and human Pdx1 fragment
分子名称: Pancreas/duodenum homeobox protein 1, Speckle-type POZ protein
著者Ostertag, M.S, Popowicz, G.M, Sattler, M.
登録日2017-12-13
公開日2018-11-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation.
Structure, 27, 2019
4JJQ
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BU of 4jjq by Molmil
Crystal structure of usp7-ntd with an e2 enzyme
分子名称: Ubiquitin carboxyl-terminal hydrolase 7, Ubiquitin-conjugating enzyme E2 E1
著者Saridakis, V.
登録日2013-03-08
公開日2013-05-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Ubiquitin-specific protease 7 is a regulator of ubiquitin-conjugating enzyme UbE2E1.
J. Biol. Chem., 288, 2013
4KG9
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BU of 4kg9 by Molmil
Crystal Structure Of USP7-NTD with MCM-BP
分子名称: Mini-chromosome maintenance complex-binding protein, Ubiquitin carboxyl-terminal hydrolase 7
著者Saridakis, V, Luthra, N.
登録日2013-04-29
公開日2013-11-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A role for USP7 in DNA replication.
Mol.Cell.Biol., 34, 2014
1YY6
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BU of 1yy6 by Molmil
The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with an EBNA1 peptide
分子名称: Epstein-Barr nuclear antigen-1, SODIUM ION, Ubiquitin carboxyl-terminal hydrolase 7
著者Saridakis, V, Sheng, Y, Sarkari, F, Holowaty, M, Shire, K, Nguyen, T, Zhang, R, Liao, J, Lee, W, Edwards, A.M, Arrowsmith, C.H, Frappier, L.
登録日2005-02-23
公開日2005-04-05
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.
Mol.Cell, 18, 2005
1YZE
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BU of 1yze by Molmil
Crystal structure of the N-terminal domain of USP7/HAUSP.
分子名称: Ubiquitin carboxyl-terminal hydrolase 7
著者Saridakis, V, Sheng, Y, Sarkari, F, Holowaty, M.N, Shire, K, Nguyen, T, Zhang, R.G, Liao, J, Lee, W, Edwards, A.M, Arrowsmith, C.H, Frappier, L.
登録日2005-02-28
公開日2005-04-05
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.
Mol.Cell, 18, 2005
2CR2
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BU of 2cr2 by Molmil
Solution structure of N-terminal domain of speckle-type POZ protein
分子名称: Speckle-type POZ protein
著者Nagashima, T, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2005-05-20
公開日2005-11-20
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献Solution structure of N-terminal domain of speckle-type POZ protein
To be Published
6I7A
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BU of 6i7a by Molmil
Co-crystal structure of human SPOP MATH domain (D140N) and human BRD3 fragment
分子名称: Bromodomain-containing protein 3, Speckle-type POZ protein
著者Ostertag, M.S, Popowicz, G.M, Sattler, M.
登録日2018-11-16
公開日2019-05-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants.
J.Mol.Biol., 431, 2019
6I41
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BU of 6i41 by Molmil
Co-crystal structure of human SPOP MATH domain (wild-type) and human BRD3 fragment
分子名称: Bromodomain-containing protein 3, Speckle-type POZ protein
著者Ostertag, M.S, Popowicz, G.M, Sattler, M.
登録日2018-11-08
公開日2019-05-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants.
J.Mol.Biol., 431, 2019
6I5P
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BU of 6i5p by Molmil
Co-crystal structure of human SPOP MATH domain (E47K) and human BRD3 fragment
分子名称: Bromodomain-containing protein 3, Speckle-type POZ protein
著者Ostertag, M.S, Popowicz, G.M, Sattler, M.
登録日2018-11-14
公開日2019-05-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants.
J.Mol.Biol., 431, 2019
6I68
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BU of 6i68 by Molmil
Co-crystal structure of human SPOP MATH domain (M117V) and human BRD3 fragment
分子名称: Bromodomain-containing protein 3, Speckle-type POZ protein
著者Ostertag, M.S, Popowicz, G.M, Sattler, M.
登録日2018-11-15
公開日2019-05-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants.
J.Mol.Biol., 431, 2019
2F1W
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BU of 2f1w by Molmil
Crystal structure of the TRAF-like domain of HAUSP/USP7
分子名称: CALCIUM ION, Ubiquitin carboxyl-terminal hydrolase 7
著者Hu, M, Gu, L, Jeffrey, P.D, Shi, Y.
登録日2005-11-15
公開日2006-02-07
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
2F1Y
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BU of 2f1y by Molmil
Crystal structure of the TRAF-like domain of HAUSP/USP7 bound to a MDM2 peptide
分子名称: HAUSP/USP7
著者Hu, M, Gu, L, Jeffrey, P.D, Shi, Y.
登録日2005-11-15
公開日2006-02-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
2F1X
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BU of 2f1x by Molmil
Crystal structure of the TRAF-like domain of HAUSP/USP7 bound to a p53 peptide
分子名称: HAUSP/USP7
著者Hu, M, Gu, L, Jeffrey, P.D, Shi, Y.
登録日2005-11-15
公開日2006-02-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
2FOJ
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BU of 2foj by Molmil
The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 364-367
分子名称: Ubiquitin carboxyl-terminal hydrolase 7, p53 peptide
著者Saridakis, V, Sheng, Y, Sarkari, F, Duan, S, Wu, T, Arrowsmith, C.H, Frappier, L.
登録日2006-01-13
公開日2006-02-14
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Molecular recognition of p53 and MDM2 by USP7/HAUSP
Nat.Struct.Mol.Biol., 13, 2006
2FOP
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The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with mdm2 peptide 147-150
分子名称: Ubiquitin carboxyl-terminal hydrolase 7, mdm2 peptide
著者Saridakis, V, Sheng, Y, Sarkari, F, Duan, S, Wu, T, Arrowsmith, C.H, Frappier, L.
登録日2006-01-13
公開日2006-02-14
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular recognition of p53 and MDM2 by USP7/HAUSP
Nat.Struct.Mol.Biol., 13, 2006
2FOO
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BU of 2foo by Molmil
The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 359-362
分子名称: Ubiquitin carboxyl-terminal hydrolase 7, p53 peptide
著者Saridakis, V, Sheng, Y, Sarkari, F, Duan, S, Wu, T, Arrowsmith, C.H, Frappier, L.
登録日2006-01-13
公開日2006-02-14
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Molecular recognition of p53 and MDM2 by USP7/HAUSP
Nat.Struct.Mol.Biol., 13, 2006
7KLZ
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BU of 7klz by Molmil
Structure of SPOP MATH domain in complex with a Geminin peptide
分子名称: Geminin peptide, PHOSPHATE ION, Speckle-type POZ protein
著者Cui, G, Botuyan, M.V, Mer, G.
登録日2020-11-01
公開日2021-08-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.
Nat Commun, 12, 2021
7LIP
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BU of 7lip by Molmil
X-ray structure of SPOP MATH domain (D140G)
分子名称: SULFATE ION, Speckle-type POZ protein
著者Botuyan, M.V, Cui, G, Mer, G.
登録日2021-01-27
公開日2021-04-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.
Sci Adv, 7, 2021

 

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