1QBH
 
 | | SOLUTION STRUCTURE OF A BACULOVIRAL INHIBITOR OF APOPTOSIS (IAP) REPEAT | | 分子名称: | INHIBITOR OF APOPTOSIS PROTEIN (2MIHB/C-IAP-1), ZINC ION | | 著者 | Hinds, M.G, Norton, R.S, Vaux, D.L, Day, C.L. | | 登録日 | 1999-04-20 | | 公開日 | 1999-10-20 | | 最終更新日 | 2022-03-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat.
Nat.Struct.Biol., 6, 1999
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1C9Q
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1F3H
 | | X-RAY CRYSTAL STRUCTURE OF THE HUMAN ANTI-APOPTOTIC PROTEIN SURVIVIN | | 分子名称: | SULFATE ION, SURVIVIN, ZINC ION | | 著者 | Verdecia, M.A, Huang, H, Dutil, E, Hunter, T, Noel, J.P. | | 登録日 | 2000-06-03 | | 公開日 | 2000-12-06 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement.
Nat.Struct.Biol., 7, 2000
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1E31
 | | SURVIVIN DIMER H. SAPIENS | | 分子名称: | APOPTOSIS INHIBITOR SURVIVIN, COBALT (II) ION, ZINC ION | | 著者 | Chantalat, L, Skoufias, D.A, Margolis, R.L, Dideberg, O. | | 登録日 | 2000-06-04 | | 公開日 | 2001-01-03 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | Crystal Structure of Human Survivin Reveals a Bow Tie-Shaped Dimer with Two Unusual Alpha-Helical Extensions
Mol.Cell, 6, 2000
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1G3F
 | | NMR STRUCTURE OF A 9 RESIDUE PEPTIDE FROM SMAC/DIABLO COMPLEXED TO THE BIR3 DOMAIN OF XIAP | | 分子名称: | INHIBITOR OF APOPTOSIS PROTEIN 3, SMAC, ZINC ION | | 著者 | Liu, Z, Sun, C, Olejniczak, E.T, Meadows, R.P, Betz, S.F, Oost, T, Herrmann, J, Wu, J.C, Fesik, S.W. | | 登録日 | 2000-10-24 | | 公開日 | 2001-01-10 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
Nature, 408, 2000
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1G73
 | | CRYSTAL STRUCTURE OF SMAC BOUND TO XIAP-BIR3 DOMAIN | | 分子名称: | INHIBITORS OF APOPTOSIS-LIKE PROTEIN ILP, SECOND MITOCHONDRIA-DERIVED ACTIVATOR OF CASPASES, ZINC ION | | 著者 | Wu, G, Chai, J, Suber, T.L, Wu, J.-W, Shi, Y. | | 登録日 | 2000-11-08 | | 公開日 | 2001-01-10 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis of IAP recognition by Smac/DIABLO.
Nature, 408, 2000
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1I4O
 | | CRYSTAL STRUCTURE OF THE XIAP/CASPASE-7 COMPLEX | | 分子名称: | BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, CASPASE-7 | | 著者 | Huang, Y, Park, Y.C, Rich, R.L, Segal, D, Myszka, D.G, Wu, H. | | 登録日 | 2001-02-22 | | 公開日 | 2001-03-21 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain.
Cell(Cambridge,Mass.), 104, 2001
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1I3O
 | | CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3 | | 分子名称: | BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, CASPASE 3, ZINC ION | | 著者 | Riedl, S.J, Renatus, M, Schwarzenbacher, R, Zhou, Q, Sun, C, Fesik, S.W, Liddington, R.C, Salvesen, G.S. | | 登録日 | 2001-02-15 | | 公開日 | 2001-03-21 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis for the inhibition of caspase-3 by XIAP.
Cell(Cambridge,Mass.), 104, 2001
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1F9X
 | | AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-3 DOMAIN OF XIAP | | 分子名称: | INHIBITOR OF APOPTOSIS PROTEIN XIAP, ZINC ION | | 著者 | Sun, C, Cai, M, Meadows, R.P, Fesik, S.W. | | 登録日 | 2000-07-11 | | 公開日 | 2001-07-11 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP.
J.Biol.Chem., 275, 2000
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1JD4
 | | Crystal Structure of DIAP1-BIR2 | | 分子名称: | APOPTOSIS 1 INHIBITOR, ZINC ION | | 著者 | Wu, J.W, Cocina, A.E, Chai, J, Hay, B.A, Shi, Y. | | 登録日 | 2001-06-12 | | 公開日 | 2001-12-05 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides.
Mol.Cell, 8, 2001
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1JD6
 | | Crystal Structure of DIAP1-BIR2/Hid Complex | | 分子名称: | APOPTOSIS 1 INHIBITOR, ZINC ION, head involution defective protein | | 著者 | Wu, J.W, Cocina, A.E, Chai, J, Hay, B.A, Shi, Y. | | 登録日 | 2001-06-12 | | 公開日 | 2001-12-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides.
Mol.Cell, 8, 2001
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1JD5
 | | Crystal Structure of DIAP1-BIR2/GRIM | | 分子名称: | APOPTOSIS 1 INHIBITOR, ZINC ION, cell death protein GRIM | | 著者 | Wu, J.W, Cocina, A.E, Chai, J, Hay, B.A, Shi, Y. | | 登録日 | 2001-06-12 | | 公開日 | 2001-12-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides.
Mol.Cell, 8, 2001
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1KMC
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1I51
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1M4M
 | | Mouse Survivin | | 分子名称: | BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5, ZINC ION | | 著者 | Muchmore, S.W, Chen, J, Jakob, C, Zakula, D, Matayoshi, E.D, Wu, W, Zhang, H, Li, F, Ng, S.C, Altieri, D.C. | | 登録日 | 2002-07-03 | | 公開日 | 2002-09-25 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | CRYSTAL STRUCTURE AND MUTAGENIC ANALYSIS OF THE INHIBITOR-OF-APOPTOSIS PROTEIN SURVIVIN
MOL.CELL, 6, 2000
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1NW9
 | | STRUCTURE OF CASPASE-9 IN AN INHIBITORY COMPLEX WITH XIAP-BIR3 | | 分子名称: | Baculoviral IAP repeat-containing protein 4, ZINC ION, caspase 9, ... | | 著者 | Shiozaki, E.N, Chai, J, Rigotti, D.J, Riedl, S.J, Li, P, Srinivasula, S.M, Alnemri, E.S, Fairman, R, Shi, Y. | | 登録日 | 2003-02-05 | | 公開日 | 2003-03-25 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Mechanism of XIAP-Mediated Inhibition of Caspase-9
Mol.Cell, 11, 2003
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1OY7
 | | Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) | | 分子名称: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, AEVVAVKSE peptide, Baculoviral IAP repeat-containing protein 7, ... | | 著者 | Franklin, M.C, Kadkhodayan, S, Ackerly, H, Alexandru, D, Distefano, M.D, Elliott, L.O, Flygare, J.A, Vucic, D, Deshayes, K, Fairbrother, W.J. | | 登録日 | 2003-04-03 | | 公開日 | 2003-08-26 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)
Biochemistry, 42, 2003
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1OXN
 | | Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) | | 分子名称: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, AEAVPWKSE peptide, Baculoviral IAP repeat-containing protein 7, ... | | 著者 | Franklin, M.C, Kadkhodayan, S, Ackerly, H, Alexandru, D, Distefano, M.D, Elliott, L.O, Flygare, J.A, Vucic, D, Deshayes, K, Fairbrother, W.J. | | 登録日 | 2003-04-03 | | 公開日 | 2003-08-26 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)
Biochemistry, 42, 2003
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1OXQ
 | | Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) | | 分子名称: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, AVPIAQKSE (Smac) peptide, Baculoviral IAP repeat-containing protein 7, ... | | 著者 | Franklin, M.C, Kadkhodayan, S, Ackerly, H, Alexandru, D, Distefano, M.D, Elliott, L.O, Flygare, J.A, Vucic, D, Deshayes, K, Fairbrother, W.J. | | 登録日 | 2003-04-03 | | 公開日 | 2003-08-26 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)
Biochemistry, 42, 2003
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1Q4Q
 | | Crystal structure of a DIAP1-Dronc complex | | 分子名称: | Apoptosis 1 inhibitor, Nedd2-like caspase CG8091-PA, ZINC ION | | 著者 | Chai, J, Yan, N, Shi, Y. | | 登録日 | 2003-08-04 | | 公開日 | 2003-11-04 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination
Nat.Struct.Biol., 10, 2003
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1SE0
 | | Crystal structure of DIAP1 BIR1 bound to a Grim peptide | | 分子名称: | Apoptosis 1 inhibitor, Cell death protein Grim, ZINC ION | | 著者 | Yan, N, Wu, J.W, Shi, Y. | | 登録日 | 2004-02-15 | | 公開日 | 2004-04-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.
Nat.Struct.Mol.Biol., 11, 2004
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1SDZ
 | | Crystal structure of DIAP1 BIR1 bound to a Reaper peptide | | 分子名称: | Apoptosis 1 inhibitor, Reaper, ZINC ION | | 著者 | Yan, N, Wu, J.W, Shi, Y. | | 登録日 | 2004-02-15 | | 公開日 | 2004-04-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.
Nat.Struct.Mol.Biol., 11, 2004
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1TFQ
 | | NMR Structure of an Antagonists of the XIAP-Caspase-9 Interaction Complexed to the BIR3 domain of XIAP | | 分子名称: | Baculoviral IAP repeat-containing protein 4, N-METHYLALANYL-3-METHYLVALYL-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE, ZINC ION | | 著者 | Oost, T.K, Sun, C, Armstrong, R.C, Al-Assaad, A.S, Betz, S.F, Deckwerth, T.L, Elmore, S.W, Meadows, R.P, Olejniczak, E.T, Oleksijew, A, Oltersdorf, T, Rosenberg, S.H, Shoemaker, A.R, Zou, H, Fesik, S.W. | | 登録日 | 2004-05-27 | | 公開日 | 2004-09-07 | | 最終更新日 | 2022-03-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer.
J.Med.Chem., 47, 2004
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1TW6
 | | Structure of an ML-IAP/XIAP chimera bound to a 9mer peptide derived from Smac | | 分子名称: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Baculoviral IAP repeat-containing protein 7, ... | | 著者 | Franklin, M.C, Vucic, D, Wallweber, H.J.A, Das, K, Shin, H, Elliott, L.O, Kadkhodayan, S, Deshayes, K, Salvesen, G.S, Fairbrother, W.J. | | 登録日 | 2004-06-30 | | 公開日 | 2004-11-02 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.713 Å) | | 主引用文献 | Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP
Biochem.J., 385, 2005
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1XB0
 | | Structure of the BIR domain of IAP-like protein 2 | | 分子名称: | Baculoviral IAP repeat-containing protein 8, Diablo homolog, mitochondrial, ... | | 著者 | Shin, H, Renatus, M, Eckelman, B.P, Nunes, V.A, Sampaio, C.A.M, Salvesen, G.S. | | 登録日 | 2004-08-27 | | 公開日 | 2004-11-02 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition
Biochem.J., 385, 2005
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