1QBH

SOLUTION STRUCTURE OF A BACULOVIRAL INHIBITOR OF APOPTOSIS (IAP) REPEAT

Summary for 1QBH

• Entry DOI: 10.2210/pdb1qbh/pdb
• Descriptor: INHIBITOR OF APOPTOSIS PROTEIN (2MIHB/C-IAP-1), ZINC ION (2 entities in total)
• Functional Keywords: inhibitor of apoptosis (iap), baculoviral iap repeat (bir), zinc binding domain, apoptosis
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (Potential): Q13490
• Total number of polymer chains: 1
• Total formula weight: 11842.73

Authors

Hinds, M.G.,Norton, R.S.,Vaux, D.L.,Day, C.L. (deposition date: 1999-04-20, release date: 1999-10-20, Last modification date: 2024-05-22)

Primary citation

Hinds, M.G.,Norton, R.S.,Vaux, D.L.,Day, C.L.
Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat.
Nat.Struct.Biol., 6:648-651, 1999

PubMed Abstract: Members of the inhibitor of apoptosis (IAP) family of proteins are able to inhibit cell death following viral infection, during development or in cell lines in vitro. All IAP proteins bear one or more baculoviral IAP repeats (BIRs). Here we describe the solution structure of the third BIR domain from the mammalian IAP homolog B (MIHB/c-IAP-1). The BIR domain has a novel fold that is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues. The structure consists of a series of short alpha-helices and turns with the zinc packed in an unusually hydrophobic environment created by residues that are highly conserved among all BIRs.

PubMed: 10404221
DOI: 10.1038/10701

Experimental method

SOLUTION NMR