PDB: 109 resultsInfo pagesStatus searchChemie searchBIRD

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3QC9	Crystal structure of cross-linked bovine GRK1 T8C/N480C double mutant complexed with ADP and Mg Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... Authors: Huang, C.-C, Tesmer, J.J.G. Deposit date: 2011-01-15 Release date: 2011-02-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Activation of G Protein-Coupled Receptor Kinase 1 Involves Interactions between Its N-Terminal Region and Its Kinase Domain. Biochemistry, 50, 2011
5UUU	Design, Synthesis, and Evaluation of the First Selective and Potent G-protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-({[4-methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]methyl}amino)-N-[2-(trifluoromethyl)benzyl]benzamide, Beta-adrenergic receptor kinase 1, ... Authors: Hoffman, I.D, Lawson, J.D. Deposit date: 2017-02-17 Release date: 2017-07-26 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure. J. Med. Chem., 60, 2017
2IHB	Crystal structure of the heterodimeric complex of human RGS10 and activated Gi alpha 3 Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(k) subunit alpha, MAGNESIUM ION, ... Authors: Soundararajan, M, Turnbull, A.P, Papagrigoriou, E, Pike, A.C.W, Bunkoczi, G, Ugochukwu, E, Gorrec, F, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Doyle, D.A, Structural Genomics Consortium (SGC) Deposit date: 2006-09-26 Release date: 2006-11-21 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc.Natl.Acad.Sci.Usa, 105, 2008
2IK8	Crystal structure of the heterodimeric complex of human RGS16 and activated Gi alpha 1 Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... Authors: Soundararajan, M, Turnbull, A.P, Papagrigoriou, E, Debreczeni, J, Gorrec, F, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Doyle, D.A, Structural Genomics Consortium (SGC) Deposit date: 2006-10-02 Release date: 2006-11-21 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc.Natl.Acad.Sci.Usa, 105, 2008
2GTP	Crystal structure of the heterodimeric complex of human RGS1 and activated Gi alpha 1 Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... Authors: Soundararajan, M, Turnbull, A.P, Ugochukwu, E, Gorrec, F, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Doyle, D.A, Structural Genomics Consortium (SGC) Deposit date: 2006-04-28 Release date: 2006-05-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc.Natl.Acad.Sci.Usa, 105, 2008
1FQJ	CRYSTAL STRUCTURE OF THE HETEROTRIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, THE GAMMA SUBUNIT OF PHOSPHODIESTERASE AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(PDEGAMMA)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)] Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(t) subunit alpha-1,Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(t) subunit alpha-1, MAGNESIUM ION, ... Authors: Slep, K.C, Kercher, M.A, He, W, Cowan, C.W, Wensel, T.G, Sigler, P.B. Deposit date: 2000-09-05 Release date: 2001-02-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A. Nature, 409, 2001
1FQK	CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)] Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(t) subunit alpha-1,Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(t) subunit alpha-1, MAGNESIUM ION, ... Authors: Slep, K.C, Kercher, M.A, He, W, Cowan, C.W, Wensel, T.G, Sigler, P.B. Deposit date: 2000-09-05 Release date: 2001-02-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A. Nature, 409, 2001
2BCJ	Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits Descriptor: G-protein-coupled receptor kinase 2, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Tesmer, J.J.G. Deposit date: 2005-10-19 Release date: 2005-12-20 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (3.061 Å) Cite: Snapshot of Activated G Proteins at the Membrane: The Gq-GRK2-G Complex Science, 310, 2005
2ACX	Crystal Structure of G protein coupled receptor kinase 6 bound to AMPPNP Descriptor: G protein-coupled receptor kinase 6, MAGNESIUM ION, PHOSPHATE ION, ... Authors: Lodowski, D.T, Tesmer, V.M, Benovic, J.L, Tesmer, J.J. Deposit date: 2005-07-19 Release date: 2006-04-25 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The Structure of G Protein-coupled Receptor Kinase (GRK)-6 Defines a Second Lineage of GRKs. J.Biol.Chem., 281, 2006

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