5UUU

Design, Synthesis, and Evaluation of the First Selective and Potent G-protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure

Summary for 5UUU

• Entry DOI: 10.2210/pdb5uuu/pdb
• Related: 5UVC
• Descriptor: Beta-adrenergic receptor kinase 1, 3-({[4-methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]methyl}amino)-N-[2-(trifluoromethyl)benzyl]benzamide, SULFATE ION, ... (5 entities in total)
• Functional Keywords: kinase, inhibitor, heart failure, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P25098
• Total number of polymer chains: 1
• Total formula weight: 64089.92

Authors

Hoffman, I.D.,Lawson, J.D. (deposition date: 2017-02-17, release date: 2017-07-26, Last modification date: 2024-03-06)

• Primary citation: Okawa, T.,Aramaki, Y.,Yamamoto, M.,Kobayashi, T.,Fukumoto, S.,Toyoda, Y.,Henta, T.,Hata, A.,Ikeda, S.,Kaneko, M.,Hoffman, I.D.,Sang, B.C.,Zou, H.,Kawamoto, T.; Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure.; J. Med. Chem., 60:6942-6990, 2017; PubMed: 28699740; DOI: 10.1021/acs.jmedchem.7b00443

Experimental method

X-RAY DIFFRACTION (2.7 Å)