7AHE
 
 | | OpuA inhibited inward facing | | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, ABC transporter permease subunit, ABC-type proline/glycine betaine transport system ATPase component | | 著者 | Sikkema, H.R, Rheinberger, J, Paulino, C, Poolman, B. | | 登録日 | 2020-09-24 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA.
Sci Adv, 6, 2020
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7AHC
 | | OpuA apo inward-facing | | 分子名称: | ABC transporter permease subunit, ABC-type proline/glycine betaine transport system ATPase component | | 著者 | Sikkema, H.R, Rheinberger, J, Paulino, C, Poolman, B. | | 登録日 | 2020-09-24 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA.
Sci Adv, 6, 2020
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7LZG
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7M1U
 | | Crystal structure of an archaeal CNNM, MtCorB, R235L mutant with C-terminal deletion | | 分子名称: | Hemolysin, contains CBS domains | | 著者 | Chen, Y.S, Kozlov, G, Gehring, K. | | 登録日 | 2021-03-15 | | 公開日 | 2021-06-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Crystal structure of an archaeal CorB magnesium transporter.
Nat Commun, 12, 2021
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7M1T
 | | Crystal structure of an archaeal CNNM, MtCorB, with C-terminal deletion in complex with Mg2+-ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Hemolysin, contains CBS domains, ... | | 著者 | Chen, Y.S, Kozlov, G, Gehring, K. | | 登録日 | 2021-03-15 | | 公開日 | 2021-06-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.26 Å) | | 主引用文献 | Crystal structure of an archaeal CorB magnesium transporter.
Nat Commun, 12, 2021
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7M74
 | | ATP-bound AMP-activated protein kinase | | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... | | 著者 | Yan, Y, Mukherjee, S, Harikumar, K.G, Strutzenberg, T, Zhou, X.E, Powell, S.K, Xu, T, Sheldon, R, Lamp, J, Brunzelle, J.S, Radziwon, K, Ellis, A, Novick, S.J, Vega, I.E, Jones, R, Miller, L.J, Xu, H.E, Griffin, P.R, Kossiakoff, A.A, Melcher, K. | | 登録日 | 2021-03-26 | | 公開日 | 2021-12-15 | | 最終更新日 | 2021-12-22 | | 実験手法 | ELECTRON MICROSCOPY (3.93 Å) | | 主引用文献 | Structure of an AMPK complex in an inactive, ATP-bound state.
Science, 373, 2021
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7MSU
 | | Crystal structure of an archaeal CNNM, MtCorB, CBS-pair domain in complex with Mg2+-ATP | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Hemolysin, ... | | 著者 | Chen, Y.S, Gehring, K. | | 登録日 | 2021-05-12 | | 公開日 | 2021-06-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Crystal structure of an archaeal CorB magnesium transporter.
Nat Commun, 12, 2021
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7OJ1
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7MYJ
 | | Structure of full length human AMPK (a2b1g1) in complex with a small molecule activator MSG011 | | 分子名称: | (5S,6R,7R,9R,13cR,14R,16aS)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,14,15,16,16a-octahydro-5H,13cH-5,9-epoxy-4b,9a,1 5-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-ol, 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, ... | | 著者 | Ovens, A.J, Gee, Y.S, Ling, N.X.Y, Waters, N.J, Yu, D, Scott, J.W, Parker, M.W, Hoffman, N.J, Kemp, B.E, Baell, J.B, Oakhill, J.S, Langendorf, C.G. | | 登録日 | 2021-05-21 | | 公開日 | 2022-06-29 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator.
Biochem.J., 479, 2022
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7OY9
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7RER
 | | HUMAN IMPDH1 TREATED WITH ATP, IMP, AND NAD+ | | 分子名称: | INOSINIC ACID, Isoform 5 of Inosine-5'-monophosphate dehydrogenase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Burrell, A.L, Kollman, J.M. | | 登録日 | 2021-07-13 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7RES
 | | HUMAN IMPDH1 TREATED WITH ATP, IMP, AND NAD+, OCTAMER-CENTERED | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Isoform 5 of Inosine-5'-monophosphate dehydrogenase 1, ... | | 著者 | Burrell, A.L, Kollman, J.M. | | 登録日 | 2021-07-13 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7RFI
 | | HUMAN RETINAL VARIANT IMPDH1(595) TREATED WITH GTP, ATP, IMP, NAD+, INTERFACE-CENTERED | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Isoform 5 of Inosine-5'-monophosphate dehydrogenase 1, ... | | 著者 | Burrell, A.L, Kollman, J.M. | | 登録日 | 2021-07-14 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7RFE
 | | HUMAN IMPDH1 TREATED WITH GTP, IMP, AND NAD+; INTERFACE-CENTERED | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | | 著者 | Burrell, A.L, Kollman, J.M. | | 登録日 | 2021-07-14 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7RFF
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7RFH
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7RFG
 | | HUMAN IMPDH1 TREATED WITH GTP, IMP, AND NAD+ OCTAMER-CENTERED | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | | 著者 | Burrell, A.L, Kollman, J.M. | | 登録日 | 2021-07-14 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7RGQ
 | | HUMAN RETINAL VARIANT IMPDH1(546) TREATED WITH GTP, ATP, IMP, NAD+; INTERFACE-CENTERED | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | | 著者 | Burrell, A.L, Kollman, J.M. | | 登録日 | 2021-07-15 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7RGI
 | | HUMAN RETINAL VARIANT IMPDH1(546) TREATED WITH GTP, ATP, IMP, NAD+; INTERFACE-CENTERED | | 分子名称: | INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Burrell, A.L, Kollman, J.M. | | 登録日 | 2021-07-15 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7RGD
 | | HUMAN RETINAL VARIANT IMPDH1(595) TREATED WITH GTP, ATP, IMP, NAD+, OCTAMER-CENTERED | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | | 著者 | Burrell, A.L, Kollman, J.M. | | 登録日 | 2021-07-15 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7RGL
 | | HUMAN RETINAL VARIANT IMPDH1(546) TREATED WITH ATP, IMP, NAD+, INTERFACE-CENTERED | | 分子名称: | INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Burrell, A.L, Kollman, J.M. | | 登録日 | 2021-07-15 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7RGM
 | | HUMAN RETINAL VARIANT IMPDH1(546) TREATED WITH ATP, IMP, NAD+, OCTAMER-CENTERED | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 1, ... | | 著者 | Burrell, A.L, Kollman, J.M. | | 登録日 | 2021-07-15 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7PJI
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7PMZ
 | | Crystal structure of Streptomyces coelicolor guaB (IMP dehydrogenase) bound to ATP and ppGpp at 2.0 A resolution | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5',3'-TETRAPHOSPHATE, Inosine-5'-monophosphate dehydrogenase, ... | | 著者 | Fernandez-Justel, D, Revuelta, J.L, Buey, R.M. | | 登録日 | 2021-09-04 | | 公開日 | 2022-05-11 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Diversity of mechanisms to control bacterial GTP homeostasis by the mutually exclusive binding of adenine and guanine nucleotides to IMP dehydrogenase.
Protein Sci., 31, 2022
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7QBJ
 | | bacterial IMPDH chimera | | 分子名称: | Inosine-5'-monophosphate dehydrogenase | | 著者 | Labesse, G, Gelin, M, Munier-Lehmann, H, Gedeon, A, Haouz, A. | | 登録日 | 2021-11-19 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases.
Protein Sci., 32, 2023
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