7RFE

HUMAN IMPDH1 TREATED WITH GTP, IMP, AND NAD+; INTERFACE-CENTERED

Summary for 7RFE

Entry DOI	10.2210/pdb7rfe/pdb
EMDB information	24439
Descriptor	Inosine-5'-monophosphate dehydrogenase 1, GUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
Functional Keywords	metabolism, filament, allostery, adenine, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	8
Total formula weight	450906.19
Authors	Burrell, A.L.,Kollman, J.M. (deposition date: 2021-07-14, release date: 2022-01-12, Last modification date: 2022-02-02)
Primary citation	Burrell, A.L.,Nie, C.,Said, M.,Simonet, J.C.,Fernandez-Justel, D.,Johnson, M.C.,Quispe, J.,Buey, R.M.,Peterson, J.R.,Kollman, J.M. IMPDH1 retinal variants control filament architecture to tune allosteric regulation. Nat.Struct.Mol.Biol., 29:47-58, 2022 Cited by PubMed: 35013599 DOI: 10.1038/s41594-021-00706-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.6 Å)

Structure validation