7RFE
HUMAN IMPDH1 TREATED WITH GTP, IMP, AND NAD+; INTERFACE-CENTERED
Summary for 7RFE
Entry DOI | 10.2210/pdb7rfe/pdb |
EMDB information | 24439 |
Descriptor | Inosine-5'-monophosphate dehydrogenase 1, GUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | metabolism, filament, allostery, adenine, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 8 |
Total formula weight | 450906.19 |
Authors | Burrell, A.L.,Kollman, J.M. (deposition date: 2021-07-14, release date: 2022-01-12, Last modification date: 2024-06-05) |
Primary citation | Burrell, A.L.,Nie, C.,Said, M.,Simonet, J.C.,Fernandez-Justel, D.,Johnson, M.C.,Quispe, J.,Buey, R.M.,Peterson, J.R.,Kollman, J.M. IMPDH1 retinal variants control filament architecture to tune allosteric regulation. Nat.Struct.Mol.Biol., 29:47-58, 2022 Cited by PubMed: 35013599DOI: 10.1038/s41594-021-00706-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.6 Å) |
Structure validation
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