7RH9
| Cryo-EM structure of human rod CNGA1/B1 channel in apo state | 分子名称: | Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-16 | 公開日 | 2021-11-03 | 最終更新日 | 2022-01-19 | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
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8SI3
| Cryo-EM structure of TRPM7 in GDN detergent in apo state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, CALCIUM ION, ... | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-04-14 | 公開日 | 2023-05-17 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | 主引用文献 | Structural mechanisms of TRPM7 activation and inhibition. Nat Commun, 14, 2023
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4X89
| NavMs voltage-gated sodium channal pore and C-terminal domain soaked with Silver nitrate | 分子名称: | HEGA-10, Ion transport protein, PENTAETHYLENE GLYCOL, ... | 著者 | Naylor, C.E, Bagneris, C, Wallace, B.A. | 登録日 | 2014-12-10 | 公開日 | 2016-03-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Molecular basis of ion permeability in a voltage-gated sodium channel. Embo J., 35, 2016
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8SIB
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7L2H
| Cryo-EM structure of unliganded full-length TRPV1 at neutral pH | 分子名称: | (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl tridecanoate, (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, ... | 著者 | Zhang, K, Julius, D, Cheng, Y. | 登録日 | 2020-12-17 | 公開日 | 2021-09-22 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
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7LP9
| Cryo-EM structure of full-length TRPV1 at 4 degrees Celsius | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7OR0
| Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 2 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Grieben, M, Pike, A.C.W, Saward, B.G, Wang, D, Mukhopadhyay, S.M.M, Moreira, T, Chalk, R, MacLean, E.M, Marsden, B.D, Burgess-Brown, N.A, Bountra, C, Schofield, C.J, Carpenter, E.P. | 登録日 | 2021-06-04 | 公開日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60 To Be Published
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7OR1
| Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 1 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Grieben, M, Pike, A.C.W, Saward, B.G, Wang, D, Mukhopadhyay, S.M.M, Moreira, T, Chalk, R, MacLean, E.M, Marsden, B.D, Burgess-Brown, N.A, Bountra, C, Schofield, C.J, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2021-06-04 | 公開日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60 TO BE PUBLISHED
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7CU3
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8FFQ
| Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and ruthenium red | 分子名称: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ERGOSTEROL, Transient receptor potential cation channel subfamily V member 5, ... | 著者 | De Jesus-Perez, J.J, Fluck, E.C, Pumroy, R.A, Protopopova, A.D, Rocereta, J.A, Moiseenkova-Bell, V.Y. | 登録日 | 2022-12-09 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Molecular details of ruthenium red pore block in TRPV channels. Embo Rep., 25, 2024
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7PQT
| Apo human Kv3.1 cryo-EM structure | 分子名称: | POTASSIUM ION, Potassium voltage-gated channel subfamily C member 1 | 著者 | Botte, M, Huber, S, Bucher, D, Klint, J.K, Rodriguez, D, Tagmose, L, Chami, M, Cheng, R, Hennig, M, Abdul Rhaman, W. | 登録日 | 2021-09-20 | 公開日 | 2022-08-17 | 最終更新日 | 2023-02-15 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators. Pnas Nexus, 1, 2022
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8BDC
| Human apo TRPM8 in a closed state (composite map) | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ... | 著者 | Palchevskyi, S, Czarnocki-Cieciura, M, Vistoli, G, Gervasoni, S, Nowak, E, Beccari, A.R, Nowotny, M, Talarico, C. | 登録日 | 2022-10-19 | 公開日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Structure of human TRPM8 channel. Commun Biol, 6, 2023
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8FOA
| Cryo-EM structure of human TRPV6 in complex with the natural phytoestrogen genistein | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2022-12-30 | 公開日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein. Nat Commun, 14, 2023
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4CBC
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7U9T
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7PXF
| Ca2+ free Drosophila Slo channel | 分子名称: | Isoform J of Calcium-activated potassium channel slowpoke, MAGNESIUM ION, POTASSIUM ION | 著者 | Raisch, T, Brockmann, A, Ebbinghaus-Kintscher, U, Freigang, J, Gutbrod, O, Kubicek, J, Maertens, B, Hofnagel, O, Raunser, S. | 登録日 | 2021-10-08 | 公開日 | 2021-12-15 | 最終更新日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | 主引用文献 | Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM. Nat Commun, 12, 2021
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7S88
| Open apo-state cryo-EM structure of human TRPV6 in glyco-diosgenin detergent | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2021-09-17 | 公開日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | 主引用文献 | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. Nat Commun, 12, 2021
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7WM2
| Cryo-EM structure of AKT1 | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium channel AKT1 | 著者 | Dongliang, L, Zijie, Z, Yannan, Q, Yuyue, T, Huaizong, S. | 登録日 | 2022-01-14 | 公開日 | 2023-01-25 | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | 主引用文献 | Structural basis for the regulation mechanism of a hyperpolarization-activated K+ channel AKT1 by AtKC1 To Be Published
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8THH
| Cryo-EM structure of Nav1.7 with LTG | 分子名称: | (6M)-6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Fan, X, Huang, J, Yan, N. | 登録日 | 2023-07-16 | 公開日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120, 2023
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6WEK
| Structure of cGMP-bound WT TAX-4 reconstituted in lipid nanodiscs | 分子名称: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CYCLIC GUANOSINE MONOPHOSPHATE, ... | 著者 | Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J. | 登録日 | 2020-04-02 | 公開日 | 2020-06-03 | 最終更新日 | 2020-07-22 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Nat.Struct.Mol.Biol., 27, 2020
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8GHF
| cryo-EM structure of hSlo1 in plasma membrane vesicles | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL, ... | 著者 | Tao, X, Zhao, C, MacKinnon, R. | 登録日 | 2023-03-10 | 公開日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Membrane protein isolation and structure determination in cell-derived membrane vesicles. Proc.Natl.Acad.Sci.USA, 120, 2023
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5KLB
| Crystal structure of the CavAb voltage-gated calcium channel(wild-type, 2.7A) | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, CALCIUM ION, ... | 著者 | Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A. | 登録日 | 2016-06-23 | 公開日 | 2016-08-31 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs. Nature, 537, 2016
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8DDQ
| cryo-EM structure of TRPM3 ion channel in the presence of soluble Gbg, focused on channel | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2022-06-18 | 公開日 | 2022-11-02 | 最終更新日 | 2023-01-18 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron, 111, 2023
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8DJ0
| Crystal structure of NavAb L123T as a basis for the human Nav1.7 Inherited Erythromelalgia I848T mutation | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein | 著者 | Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A. | 登録日 | 2022-06-29 | 公開日 | 2023-04-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7. Proc.Natl.Acad.Sci.USA, 120, 2023
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7D4P
| Structure of human TRPC5 in complex with clemizole | 分子名称: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole, ... | 著者 | Chen, L, Song, K, Wei, M, Guo, W. | 登録日 | 2020-09-24 | 公開日 | 2021-03-31 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife, 10, 2021
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