7WRA
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7WRD
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7UA1
| Structure of PKA phosphorylated human RyR2-R2474S in the closed state in the presence of ARM210 | 分子名称: | 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | 著者 | Miotto, M.C, Marks, A.R. | 登録日 | 2022-03-11 | 公開日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment. Sci Adv, 8, 2022
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8SI8
| Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in complex with inhibitor VER155008 in closed state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, ... | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-04-14 | 公開日 | 2023-05-17 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Structural mechanisms of TRPM7 activation and inhibition. Nat Commun, 14, 2023
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8SEY
| Cryo-EM Structure of RyR1 + Adenosine (Local Refinement of TMD) | 分子名称: | ADENOSINE, Ryanodine receptor 1, ZINC ION | 著者 | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | 登録日 | 2023-04-10 | 公開日 | 2023-05-24 | 最終更新日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023
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6JUH
| structure of CavAb in complex with efonidipine | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-[phenyl-(phenylmethyl)amino]ethyl (4~{R})-5-(5,5-dimethyl-2-oxidanylidene-1,3,2$l^{5}-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate, ... | 著者 | Tang, L, Xu, F. | 登録日 | 2019-04-13 | 公開日 | 2019-11-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis for efonidipine block of a voltage-gated Ca2+channel. Biochem.Biophys.Res.Commun., 513, 2019
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9AYK
| Cryo-EM structure of human Cav3.2 with ML218 | 分子名称: | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-dichloro-N-{[(1R,5S,6r)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl}benzamide, ... | 著者 | Fan, X, Huang, J, Yan, N. | 登録日 | 2024-03-08 | 公開日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for human Ca v 3.2 inhibition by selective antagonists. Cell Res., 2024
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7YG5
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9AYG
| Cryo-EM structure of apo state human Cav3.2 | 分子名称: | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Fan, X, Huang, J, Yan, N. | 登録日 | 2024-03-07 | 公開日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for human Ca v 3.2 inhibition by selective antagonists. Cell Res., 2024
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7JPK
| Rabbit Cav1.1 in the presence of 100 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.0 Angstrom resolution | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, CALCIUM ION, ... | 著者 | Yan, N, Gao, S. | 登録日 | 2020-08-09 | 公開日 | 2020-11-18 | 最終更新日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Ca v 1.1 by Dihydropyridine Compounds*. Angew.Chem.Int.Ed.Engl., 60, 2021
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8U30
| TRPV1 in nanodisc bound with diC8-PIP2 in the closed state | 分子名称: | SODIUM ION, Transient receptor potential cation channel subfamily V member 1, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Arnold, W.R, Julius, D, Cheng, Y. | 登録日 | 2023-09-06 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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6YSN
| Human TRPC5 in complex with Pico145 (HC-608) | 分子名称: | 7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)-8-[3-(trifluoromethyloxy)phenoxy]purine-2,6-dione, Maltose/maltodextrin-binding periplasmic protein,Short transient receptor potential channel 5 | 著者 | Wright, D.J, Johnson, R.M, Muench, S.P, Bon, R.S. | 登録日 | 2020-04-22 | 公開日 | 2020-12-02 | 最終更新日 | 2020-12-09 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site. Commun Biol, 3, 2020
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8WE9
| Human L-type voltage-gated calcium channel Cav1.2 (Class I) in the presence of pinaverium at 3.0 Angstrom resolution | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Fan, X, Yan, N. | 登録日 | 2023-09-17 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
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8X43
| human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2 | 分子名称: | Calmodulin-1, N-(4-azanyl-1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2 | 著者 | Ma, D, Guo, J. | 登録日 | 2023-11-15 | 公開日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | A small-molecule activation mechanism that directly opens the KCNQ2 channel. Nat.Chem.Biol., 2024
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7UHG
| Human L-type voltage-gated calcium channel Cav1.3 at 3.0 Angstrom resolution | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Yan, N. | 登録日 | 2022-03-26 | 公開日 | 2022-05-11 | 最終更新日 | 2022-10-12 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for pore blockade of human voltage-gated calcium channel Ca v 1.3 by motion sickness drug cinnarizine. Cell Res., 32, 2022
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8DDU
| cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state3 | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2022-06-19 | 公開日 | 2022-11-02 | 最終更新日 | 2023-01-18 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron, 111, 2023
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7UKC
| Human Kv4.2-KChIP2 channel complex in an inactivated state, class 1, transmembrane region | 分子名称: | POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | 著者 | Zhao, H, Dai, Y, Lee, C.H. | 登録日 | 2022-04-01 | 公開日 | 2022-06-29 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes. Mol.Cell, 82, 2022
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6X2J
| Structure of human TRPA1 in complex with agonist GNE551 | 分子名称: | 5-amino-1-[(4-bromo-2-fluorophenyl)methyl]-N-(2,5-dimethoxyphenyl)-1H-1,2,3-triazole-4-carboxamide, Transient receptor potential cation channel subfamily A member 1 | 著者 | Rohou, A, Rouge, L, Chen, H. | 登録日 | 2020-05-20 | 公開日 | 2020-11-18 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel. Neuron, 109, 2021
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7VFU
| Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to ziconotide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Dong, Y, Gao, Y, Wang, Y, Zhao, Y. | 登録日 | 2021-09-13 | 公開日 | 2021-11-03 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Closed-state inactivation and pore-blocker modulation mechanisms of human Ca V 2.2. Cell Rep, 37, 2021
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7VFV
| Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to PD173212 | 分子名称: | (2~{S})-~{N}-[(2~{S})-1-(~{tert}-butylamino)-1-oxidanylidene-3-(4-phenylmethoxyphenyl)propan-2-yl]-2-[(4-~{tert}-butylphenyl)methyl-methyl-amino]-4-methyl-pentanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Dong, Y, Gao, Y, Wang, Y, Zhao, Y. | 登録日 | 2021-09-13 | 公開日 | 2021-11-03 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Closed-state inactivation and pore-blocker modulation mechanisms of human Ca V 2.2. Cell Rep, 37, 2021
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8E58
| Rabbit L-type voltage-gated calcium channel Cav1.1 in the presence of Amiodarone and 1 mM MNI-1 at 3.0 Angstrom resolution | 分子名称: | (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Yan, N. | 登録日 | 2022-08-20 | 公開日 | 2022-12-07 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels. Cell, 185, 2022
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7E4T
| Human TRPC5 apo state structure at 3 angstrom | 分子名称: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, ... | 著者 | Chen, L, Song, K, Wei, M, Guo, W. | 登録日 | 2021-02-15 | 公開日 | 2021-03-31 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife, 10, 2021
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7SIP
| Structure of shaker-IR | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel protein Shaker | 著者 | Tan, X, Bae, C, Stix, R, Fernandez, A.I, Huffer, K, Chang, T, Jiang, J, Faraldo-Gomez, J.D, Swartz, K.J. | 登録日 | 2021-10-14 | 公開日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure of the Shaker Kv channel and mechanism of slow C-type inactivation. Sci Adv, 8, 2022
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7WFR
| Human Nav1.8 with A-803467, class III | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, N, Pan, X.J, Huang, X.S, Huang, G.X. | 登録日 | 2021-12-27 | 公開日 | 2022-08-03 | 最終更新日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8. Proc.Natl.Acad.Sci.USA, 119, 2022
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6EBL
| The voltage-activated Kv1.2-2.1 paddle chimera channel in lipid nanodiscs, cytosolic domain | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Potassium voltage-gated channel subfamily A member 2,Potassium voltage-gated channel subfamily B member 2 chimera, Voltage-gated potassium channel subunit beta-2 | 著者 | Matthies, D, Bae, C, Fox, T, Bartesaghi, A, Subramaniam, S, Swartz, K.J. | 登録日 | 2018-08-06 | 公開日 | 2018-08-22 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs. Elife, 7, 2018
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