8SI4
| Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in open state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, CALCIUM ION, ... | Authors: | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | Deposit date: | 2023-04-14 | Release date: | 2023-05-17 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (2.46 Å) | Cite: | Structural mechanisms of TRPM7 activation and inhibition. Nat Commun, 14, 2023
|
|
8SI3
| Cryo-EM structure of TRPM7 in GDN detergent in apo state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, CALCIUM ION, ... | Authors: | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | Deposit date: | 2023-04-14 | Release date: | 2023-05-17 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (2.61 Å) | Cite: | Structural mechanisms of TRPM7 activation and inhibition. Nat Commun, 14, 2023
|
|
8SI2
| Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in apo state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, CHOLESTEROL, ... | Authors: | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | Deposit date: | 2023-04-14 | Release date: | 2023-05-17 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (2.19 Å) | Cite: | Structural mechanisms of TRPM7 activation and inhibition. Nat Commun, 14, 2023
|
|
8SF0
| Cryo-EM Structure of RyR1 + cAMP (Local Refinement of TMD) | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Ryanodine receptor 1, ZINC ION | Authors: | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | Deposit date: | 2023-04-10 | Release date: | 2023-05-24 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023
|
|
8SEZ
| Cryo-EM Structure of RyR1 + Adenine (Local Refinement of TMD) | Descriptor: | ADENINE, Ryanodine receptor 1, ZINC ION | Authors: | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | Deposit date: | 2023-04-10 | Release date: | 2023-05-24 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023
|
|
8SEY
| Cryo-EM Structure of RyR1 + Adenosine (Local Refinement of TMD) | Descriptor: | ADENOSINE, Ryanodine receptor 1, ZINC ION | Authors: | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | Deposit date: | 2023-04-10 | Release date: | 2023-05-24 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023
|
|
8SEX
| Cryo-EM Structure of RyR1 + AMP (Local Refinement of TMD) | Descriptor: | ADENOSINE MONOPHOSPHATE, Ryanodine receptor 1, ZINC ION | Authors: | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | Deposit date: | 2023-04-10 | Release date: | 2023-05-24 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023
|
|
8SEW
| Cryo-EM Structure of RyR1 + ADP (Local Refinement of TMD) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Ryanodine receptor 1, ZINC ION | Authors: | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | Deposit date: | 2023-04-10 | Release date: | 2023-05-24 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023
|
|
8SEV
| Cryo-EM Structure of RyR1 + ATP-gamma-S (Local Refinement of TMD) | Descriptor: | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Ryanodine receptor 1, ZINC ION | Authors: | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | Deposit date: | 2023-04-10 | Release date: | 2023-05-24 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023
|
|
8SEU
| Cryo-EM Structure of RyR1 (Local Refinement of TMD) | Descriptor: | Ryanodine receptor 1, ZINC ION | Authors: | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | Deposit date: | 2023-04-10 | Release date: | 2023-05-24 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023
|
|
8SET
| Cryo-EM Structure of RyR1 + cAMP | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ... | Authors: | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | Deposit date: | 2023-04-10 | Release date: | 2023-05-24 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023
|
|
8SES
| Cryo-EM Structure of RyR1 + Adenine | Descriptor: | ADENINE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ... | Authors: | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | Deposit date: | 2023-04-10 | Release date: | 2023-05-24 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.98 Å) | Cite: | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023
|
|
8SER
| Cryo-EM Structure of RyR1 + Adenosine | Descriptor: | ADENOSINE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ... | Authors: | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | Deposit date: | 2023-04-10 | Release date: | 2023-05-24 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023
|
|
8SEQ
| Cryo-EM Structure of RyR1 + AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ... | Authors: | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | Deposit date: | 2023-04-10 | Release date: | 2023-05-24 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023
|
|
8SEP
| Cryo-EM Structure of RyR1 + ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ... | Authors: | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | Deposit date: | 2023-04-10 | Release date: | 2023-05-24 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023
|
|
8SEO
| Cryo-EM Structure of RyR1 + ATP-gamma-S | Descriptor: | Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Ryanodine receptor 1, ... | Authors: | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | Deposit date: | 2023-04-10 | Release date: | 2023-05-24 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.92 Å) | Cite: | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023
|
|
8SEN
| Cryo-EM Structure of RyR1 | Descriptor: | Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ZINC ION | Authors: | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | Deposit date: | 2023-04-10 | Release date: | 2023-05-24 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023
|
|
8SDA
| CryoEM structure of rat Kv2.1(1-598) L403A mutant in nanodiscs | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1 | Authors: | Tan, X, Swartz, K.J. | Deposit date: | 2023-04-06 | Release date: | 2023-09-27 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Inactivation of the Kv2.1 channel through electromechanical coupling. Nature, 622, 2023
|
|
8SD3
| CryoEM structure of rat Kv2.1(1-598) wild type in nanodiscs | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1 | Authors: | Tan, X, Swartz, K.J. | Deposit date: | 2023-04-06 | Release date: | 2023-09-27 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Inactivation of the Kv2.1 channel through electromechanical coupling. Nature, 622, 2023
|
|
8S9C
| Cryo-EM structure of Nav1.7 with CBZ | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Fan, X, Huang, J, Yan, N. | Deposit date: | 2023-03-27 | Release date: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
|
|
8S9B
| Cryo-EM structure of Nav1.7 with LCM | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Fan, X, Huang, J, Yan, N. | Deposit date: | 2023-03-27 | Release date: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
|
|
8S3E
| Structure of rabbit Slo1 in complex with gamma1/LRRC26 | Descriptor: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, CALCIUM ION, CHOLESTEROL, ... | Authors: | Redhardt, M, Raunser, S, Raisch, T. | Deposit date: | 2024-02-20 | Release date: | 2024-04-10 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.39 Å) | Cite: | Cryo-EM structure of the Slo1 potassium channel with the auxiliary gamma 1 subunit suggests a mechanism for depolarization-independent activation. Febs Lett., 598, 2024
|
|
8QUD
| Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT5 | Descriptor: | (5R)-5-ethyl-3-(6-spiro[2H-1-benzofuran-3,1'-cyclopropane]-4-yloxypyridin-3-yl)imidazolidine-2,4-dione, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Chi, G, Mckinley, G, Marsden, B, Pike, A.C.W, Ye, M, Brooke, L.M, Bakshi, S, Lakshminarayana, B, Pilati, N, Marasco, A, Gunthorpe, M, Alvaro, G.S, Large, C.H, Williams, E, Sauer, D.B. | Deposit date: | 2023-10-16 | Release date: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | The binding and mechanism of a positive allosteric modulator of Kv3 channels. Nat Commun, 15, 2024
|
|
8QUC
| Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT1 | Descriptor: | (5R)-5-ethyl-3-[6-(3-methoxy-4-methyl-phenoxy)pyridin-3-yl]imidazolidine-2,4-dione, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Chi, G, Mckinley, G, Marsden, B, Pike, A.C.W, Ye, M, Brooke, L.M, Bakshi, S, Pilati, N, Marasco, A, Gunthorpe, M, Alvaro, G, Large, C, Lakshminaraya, B, Williams, E, Sauer, D.B. | Deposit date: | 2023-10-16 | Release date: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | The binding and mechanism of a positive allosteric modulator of Kv3 channels. Nat Commun, 15, 2024
|
|
8JKM
| RN-1747 bound state of mTRPV4 | Descriptor: | Transient receptor potential cation channel subfamily V member 4 | Authors: | Zhen, W.X, Yang, F. | Deposit date: | 2023-06-01 | Release date: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.98 Å) | Cite: | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
|
|