PDB: 469 件ウェブページステータス検索Chemie searchBIRD

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7N65	Complex structure of HIV superinfection Fab QA013.2 and BG505.SOSIP.664 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp41, ... 著者 Mangala Prasad, V, Shipley, M.M, Overbaugh, J.M, Lee, K.K. 登録日 2021-06-07 公開日 2021-07-28 実験手法 ELECTRON MICROSCOPY (4.15 Å) 主引用文献 Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection. Elife, 10, 2021
7N6U	Structure of uncleaved HIV-1 JR-FL Env glycoprotein trimer in state U1 bound to small Molecule HIV-1 Entry Inhibitor BMS-378806 分子名称: 1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zhang, S, Wang, K, Mao, Y. 登録日 2021-06-09 公開日 2021-09-22 最終更新日 2021-12-08 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Asymmetric Structures and Conformational Plasticity of the Uncleaved Full-Length Human Immunodeficiency Virus Envelope Glycoprotein Trimer. J.Virol., 95, 2021
7N6W	Structure of uncleaved HIV-1 JR-FL Env glycoprotein trimer in state U2 bound to small Molecule HIV-1 Entry Inhibitor BMS-378806 分子名称: 1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zhang, S, Wang, K, Mao, Y. 登録日 2021-06-09 公開日 2021-09-22 最終更新日 2021-12-08 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Asymmetric Structures and Conformational Plasticity of the Uncleaved Full-Length Human Immunodeficiency Virus Envelope Glycoprotein Trimer. J.Virol., 95, 2021
7N28	Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J033 in complex with HIV-1 Env 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3BNC117 antibody heavy chain, ... 著者 Zhou, T, Gao, F. 登録日 2021-05-28 公開日 2022-04-06 最終更新日 2022-06-22 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2. Adv Sci, 9, 2022
7PC2	HIV-1 Env (BG505 SOSIP.664) in complex with the IgA bNAb 7-269 and the antibody 3BNC117. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3BNC IgG Fab heavy chain, ... 著者 Fernandez, I, Bontems, F, Pehau-Arnaudet, G, Rey, F. 登録日 2021-08-03 公開日 2022-02-23 最終更新日 2022-03-16 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller. J.Exp.Med., 219, 2022
8TTW	Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074 分子名称: 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Tolbert, W.D, Pozharski, E, Pazgier, M. 登録日 2023-08-15 公開日 2023-11-08 実験手法 ELECTRON MICROSCOPY (2.96 Å) 主引用文献 Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir. Nat Commun, 14, 2023
8SXI	CH505 Disulfide Stapled SOSIP Bound to b12 Fab 分子名称: Envelope glycoprotein gp160, HIV-1 gp41, b12 Heavy Chain, ... 著者 Henderson, R. 登録日 2023-05-22 公開日 2024-02-14 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Microsecond dynamics control the HIV-1 Envelope conformation. Sci Adv, 10, 2024
8TGO	Crystal structure of the BG505 triple tandem trimer gp140 HIV-1 Env in complex with PGT124 and 35O22 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 scFv, ... 著者 Xian, Y, Yuan, M, Wilson, I.A. 登録日 2023-07-12 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (5.75 Å) 主引用文献 Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines. Npj Vaccines, 9, 2024
8TNG	Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody R27 targeting the CD4-binding site 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD4-binding site targeting nanobody R27, ... 著者 Zhou, T, Kwong, P.D, Xu, J. 登録日 2023-08-01 公開日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.58 Å) 主引用文献 Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody R27 targeting the CD4-binding site To Be Published
8TNH	Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody G36 targeting the CD4-binding site 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD4-binding site nanobody G36, ... 著者 Zhou, T, Kwong, P.D, Xu, J. 登録日 2023-08-01 公開日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.32 Å) 主引用文献 Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody G36 targeting the CD4-binding site To Be Published
8TNI	Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing bi-specific antibody CAP256L-R27 targeting the CD4-binding site and the V2-apex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 BG505 DS-SOSIP gp120, ... 著者 Zhou, T, Morano, N.C, Roark, R.S, Kwong, P.D, Xu, J. 登録日 2023-08-01 公開日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.61 Å) 主引用文献 Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing bi-specific antibody CAP256L-R27 targeting the CD4-binding site and the V2-apex To Be Published
3U7Y	Structure of NIH45-46 Fab in complex with gp120 of 93TH057 HIV 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CITRATE ANION, ... 著者 Diskin, R, Bjorkman, P.J. 登録日 2011-10-14 公開日 2011-11-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4478 Å) 主引用文献 Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design. Science, 334, 2011
3HI1	Structure of HIV-1 gp120 (core with V3) in Complex with CD4-Binding-Site Antibody F105 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, F105 Heavy Chain, F105 Light Chain, ... 著者 Kwon, Y.D, Chen, L, Zhou, T, Wu, X, O'Dell, S, Cavacini, L, Hessell, A.J, Pancera, M, Tang, M, Xu, L, Yang, Z, Zhang, M.-Y, Arthos, J, Burton, D.R, Dimitrov, D, Nabel, G.J, Posner, M, Sodroski, J, Wyatt, R, Mascola, J.R, Kwong, P.D. 登録日 2009-05-18 公開日 2009-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120. Science, 326, 2009
7UCF	Structure of the BG505 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24 分子名称: 10-1074 Fab heavy chain, 10-1074 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Barnes, C.O, Bjorkman, P.J. 登録日 2022-03-16 公開日 2022-08-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 A naturally arising broad and potent CD4-binding site antibody with low somatic mutation. Sci Adv, 8, 2022
7UCG	Structure of the DU422 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24 分子名称: 10-1074 Fab heavy chain, 10-1074 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Barnes, C.O, Bjorkman, P.J. 登録日 2022-03-16 公開日 2022-08-17 最終更新日 2022-09-07 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 A naturally arising broad and potent CD4-binding site antibody with low somatic mutation. Sci Adv, 8, 2022
7UGO	Cryo-EM structure of BG24 inferred germline Fabs with mature CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 分子名称: 10-1074 Fab heavy chain, 10-1074 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Dam, K.A, Bjorkman, P.J. 登録日 2022-03-25 公開日 2022-10-26 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design. Nat Commun, 13, 2022
7UGN	Cryo-EM structure of BG24 inferred germline Fabs with germline CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 - Class 1 分子名称: 10-1074 Fab heavy chain, 10-1074 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Dam, K.A, Bjorkman, P.J. 登録日 2022-03-25 公開日 2022-10-26 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design. Nat Commun, 13, 2022
7UGP	Cryo-EM structure of BG24 Fabs with an inferred germline light chain and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 containing the N276 gp120 glycan- Class 1 分子名称: 10-1074 Fab heavy chain, 10-1074 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Dam, K.A, Bjorkman, P.J. 登録日 2022-03-25 公開日 2022-11-09 最終更新日 2022-11-16 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design. Nat Commun, 13, 2022
7UR6	Cryo-EM structure of SHIV-elicited, FP-directed Rhesus Fab RM6561.DH1021.14 in complex with stabilized HIV-1 Env Ce1176 DS-SOSIP.664 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain, ... 著者 Gorman, J, Kwong, P.D. 登録日 2022-04-21 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (3.46 Å) 主引用文献 Cryo-EM structure of SHIV-elicited, FP-directed Rhesus Fab RM6561.DH1021.14 in complex with stabilized HIV-1 Env Ce1176 DS-SOSIP.664 To Be Published
7UOJ	The CryoEM structure of N49-P9.6-FR3 and PGT121 Fabs in complex with BG505 SOSIP.664 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... 著者 Nguyen, D.N, Tolbert, W.D, Pazgier, M. 登録日 2022-04-13 公開日 2023-05-03 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.02 Å) 主引用文献 The structure of N49-P9.6-FR3 and PGT121 Fabs in complex with BG505 SOSIP To Be Published
2NY7	HIV-1 gp120 Envelope Glycoprotein Complexed with the Broadly Neutralizing CD4-Binding-Site Antibody b12 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY b12, HEAVY CHAIN, ... 著者 Zhou, T, Xu, L, Dey, B, Hessell, A.J, Van Ryk, D, Xiang, S.H, Yang, X, Zhang, M.Y, Zwick, M.B, Arthos, J, Burton, D.R, Dimitrov, D.S, Sodroski, J, Wyatt, R, Nabel, G.J, Kwong, P.D. 登録日 2006-11-20 公開日 2007-02-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature, 445, 2007
5FYL	Crystal Structure at 3.7 A Resolution of Fully Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122 and 35O22 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 ANTIBODY FAB HEAVY CHAIN, ... 著者 Stewart-Jones, G.B.E, Zhou, T, Thomas, P.V, Kwong, P.D. 登録日 2016-03-08 公開日 2016-04-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G Cell(Cambridge,Mass.), 165, 2016
5FUU	Ectodomain of cleaved wild type JR-FL EnvdCT trimer in complex with PGT151 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Lee, J.H, Ward, A.B. 登録日 2016-01-29 公開日 2016-03-09 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Cryo-Em Structure of a Native, Fully Glycosylated and Cleaved HIV-1 Envelope Trimer Science, 351, 2016
5FYJ	Crystal Structure at 3.4 A Resolution of Fully Glycosylated HIV-1 Clade G X1193.c1 SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122, 35O22 and VRC01 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Stewart-Jones, G.B.E, Zhou, T, Thomas, P.V, Kwong, P.D. 登録日 2016-03-08 公開日 2016-04-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G Cell(Cambridge,Mass.), 165, 2016
5FYK	Crystal Structure at 3.7 A Resolution of Fully Glycosylated HIV-1 Clade B JR-FL SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122, 35O22 and VRC01 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22, ... 著者 Stewart-Jones, G.B.E, Zhou, T, Thomas, P.V, Kwong, P.D. 登録日 2016-03-08 公開日 2016-04-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.107 Å) 主引用文献 Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G Cell(Cambridge,Mass.), 165, 2016

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