PDB: 413 件ウェブページステータス検索Chemie searchBIRD

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5UUM	Human Mcl-1 in complex with a Bfl-1-specific selected peptide 分子名称: Bfl-1 specific peptide FS2, Induced myeloid leukemia cell differentiation protein Mcl-1, SULFATE ION, ... 著者 Jenson, J.M, Grant, R.A, Keating, A.E. 登録日 2017-02-17 公開日 2017-06-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.346 Å) 主引用文献 Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1. Elife, 6, 2017
5UUP	Human Bfl-1 covalently cross-linked to an electrophilic variant of a Bfl-1-specific selected peptide 分子名称: Bcl-2-related protein A1, Bfl-1-specific selected peptide, SULFATE ION 著者 Jenson, J.M, Grant, R.A, Keating, A.E. 登録日 2017-02-17 公開日 2017-06-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.726 Å) 主引用文献 Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1. Elife, 6, 2017
5UUL	Human Bfl-1 in complex with PUMA BH3 分子名称: Bcl-2-binding component 3, Bcl-2-related protein A1, SULFATE ION 著者 Jenson, J.M, Grant, R.A, Keating, A.E. 登録日 2017-02-17 公開日 2017-06-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1. Elife, 6, 2017
5VAY	Bcl-2 complex with Beclin 1 T108D BH3 domain 分子名称: Apoptosis regulator Bcl-2 -- Bcl-2-like protein 1 Chimera, Beclin-1 著者 Lee, E.F, Smith, B.J, Yao, S, Fairlie, W.D. 登録日 2017-03-28 公開日 2018-04-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.804 Å) 主引用文献 Bcl-2 complex with Beclin 1 pT108 BH3 domain To Be Published
5VAX	Bcl-2 complex with Beclin 1 BH3 domain 分子名称: Apoptosis regulator Bcl-2 -- Bcl-2-like protein 1 Chimera, Beclin-1 著者 Lee, E.F, Smith, B.J, Yao, S, Fairlie, W.D. 登録日 2017-03-28 公開日 2018-04-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Bcl-2 complex with Beclin 1 pT108 BH3 domain To Be Published
5VAU	Bcl-2 complex with Beclin 1 BH3 domain 分子名称: Apoptosis regulator Bcl-2 -- Bcl-2-like protein 1 Chimera, Beclin-1 著者 Lee, E.F, Smith, B.J, Yao, S, Fairlie, W.D. 登録日 2017-03-28 公開日 2018-04-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.754 Å) 主引用文献 Bcl-2 complex with Beclin 1 BH3 domain To Be Published
5VKC	Crystal structure of MCL-1 in complex with a BIM competitive inhibitor 分子名称: 7-(3-{[4-(4-acetylpiperazin-1-yl)phenoxy]methyl}-1,5-dimethyl-1H-pyrazol-4-yl)-3-{3-[(naphthalen-1-yl)oxy]propyl}-1-[(pyridin-3-yl)methyl]-1H-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION 著者 Judge, R.A, Souers, A.J. 登録日 2017-04-21 公開日 2017-05-03 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity. J. Med. Chem., 58, 2015
5VMN	Crystal structure of grouper iridovirus GIV66 分子名称: 1,2-ETHANEDIOL, Bak protein, NITRATE ION 著者 Banjara, S, Kvansakul, M. 登録日 2017-04-27 公開日 2018-03-07 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Grouper iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim. J. Biol. Chem., 293, 2018
5VMO	Crystal structure of grouper iridovirus GIV66:Bim complex 分子名称: 1,2-ETHANEDIOL, Bak protein, Bcl-2 interacting mediator of cell death, ... 著者 Banjara, S, Kvansakul, M. 登録日 2017-04-28 公開日 2018-03-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Grouper iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim. J. Biol. Chem., 293, 2018
5VWV	Bak core latch dimer in complex with Bim-BH3 - Cubic 分子名称: 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, ... 著者 Brouwer, J.M, Colman, P.M, Czabotar, P.E. 登録日 2017-05-23 公開日 2017-11-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.897 Å) 主引用文献 Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design. Mol. Cell, 68, 2017
5VX2	Mcl-1 in complex with Bim-h3Pc-RT 分子名称: 1,2-ETHANEDIOL, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog,Induced myeloid leukemia cell differentiation protein Mcl-1 chimera 著者 Cowan, A.D, Brouwer, J.M, Colman, P.M, Czabotar, P.E. 登録日 2017-05-23 公開日 2017-11-15 最終更新日 2020-01-08 実験手法 X-RAY DIFFRACTION (1.851 Å) 主引用文献 Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design. Mol. Cell, 68, 2017
5VX1	Bak L100A 分子名称: Bcl-2 homologous antagonist/killer 著者 Brouwer, J.M, Colman, P.M, Czabotar, P.E. 登録日 2017-05-23 公開日 2017-11-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.224 Å) 主引用文献 Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design. Mol. Cell, 68, 2017
5VX0	Bak in complex with Bim-h3Glg 分子名称: 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, ... 著者 Brouwer, J.M, Lan, P, Lessene, G, Colman, P.M, Czabotar, P.E. 登録日 2017-05-23 公開日 2017-11-15 最終更新日 2020-01-08 実験手法 X-RAY DIFFRACTION (1.599 Å) 主引用文献 Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design. Mol. Cell, 68, 2017
5VWW	Bak core latch dimer in complex with Bim-RT - Tetragonal 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, BROMIDE ION, Bcl-2 homologous antagonist/killer, ... 著者 Brouwer, J.M, Colman, P.M, Czabotar, P.E. 登録日 2017-05-23 公開日 2017-11-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.802 Å) 主引用文献 Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design. Mol. Cell, 68, 2017
5VWZ	Bak in complex with Bim-h3Pc 分子名称: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, AMMONIUM ION, Bcl-2 homologous antagonist/killer, ... 著者 Brouwer, J.M, Colman, P.M, Czabotar, P.E. 登録日 2017-05-23 公開日 2017-11-15 最終更新日 2020-01-08 実験手法 X-RAY DIFFRACTION (1.622 Å) 主引用文献 Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design. Mol. Cell, 68, 2017
5VWY	Bak core latch dimer in complex with Bim-h3Pc-RT 分子名称: Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, PHOSPHATE ION 著者 Brouwer, J.M, Colman, P.M, Czabotar, P.E. 登録日 2017-05-23 公開日 2017-11-15 最終更新日 2020-01-08 実験手法 X-RAY DIFFRACTION (1.555 Å) 主引用文献 Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design. Mol. Cell, 68, 2017
5VX3	Bcl-xL in complex with Bim-h3Pc-RT 分子名称: 1,2-ETHANEDIOL, Bcl-2-like protein 1, Bcl-2-like protein 11 著者 Cowan, A.D, Brouwer, J.M, Colman, P.M, Czabotar, P.E. 登録日 2017-05-23 公開日 2017-11-15 最終更新日 2020-01-08 実験手法 X-RAY DIFFRACTION (1.945 Å) 主引用文献 Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design. Mol. Cell, 68, 2017
5VWX	Bak core latch dimer in complex with Bim-h0-h3Glt 分子名称: 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11 著者 Brouwer, J.M, Lan, P, Lessene, G, Colman, P.M, Czabotar, P.E. 登録日 2017-05-23 公開日 2017-11-15 最終更新日 2020-01-08 実験手法 X-RAY DIFFRACTION (2.489 Å) 主引用文献 Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design. Mol. Cell, 68, 2017
5W62	Crystal structure of mouse BAX monomer 分子名称: Apoptosis regulator BAX, SULFATE ION 著者 Robin, A.Y, Colman, P.M, Czabotar, P.E, Luo, C.S. 登録日 2017-06-16 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.196 Å) 主引用文献 Ensemble Properties of Bax Determine Its Function. Structure, 26, 2018
5W5X	Crystal structure of BAXP168G in complex with an activating antibody 分子名称: 1,2-ETHANEDIOL, 3C10 Fab' heavy chain, 3C10 Fab' light chain, ... 著者 Robin, A.Y, Colman, P.M, Czabotar, P.E. 登録日 2017-06-16 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Ensemble Properties of Bax Determine Its Function. Structure, 26, 2018
5W5Z	Crystal structure of BAXP168G in complex with an activating antibody at high resolution 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3C10 Fab heavy chain, ... 著者 Robin, A.Y, Colman, P.M, Czabotar, P.E. 登録日 2017-06-16 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.997 Å) 主引用文献 Ensemble Properties of Bax Determine Its Function. Structure, 26, 2018
5W60	Crystal structure of BAXP168G monomer cryo-protected with ethylene glycol 分子名称: Apoptosis regulator BAX, SULFATE ION 著者 Robin, A.Y, Colman, P.M, Czabotar, P.E. 登録日 2017-06-16 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.803 Å) 主引用文献 Ensemble Properties of Bax Determine Its Function. Structure, 26, 2018
5W61	Crystal structure of BAXP168G monomer co-crystallized with glycerol 分子名称: Apoptosis regulator BAX 著者 Robin, A.Y, Colman, P.M, Czabotar, P.E. 登録日 2017-06-16 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Ensemble Properties of Bax Determine Its Function. Structure, 26, 2018
5W63	Crystal structure of channel catfish BAX 分子名称: 1,2-ETHANEDIOL, Apoptosis regulator bax, SULFATE ION 著者 Robin, A.Y, Colman, P.M, Czabotar, P.E, Luo, C.S. 登録日 2017-06-16 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.436 Å) 主引用文献 Ensemble Properties of Bax Determine Its Function. Structure, 26, 2018
5W89	Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-18 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, modified Bim BH3 peptide SAH-MS1-18 著者 Rezaei Araghi, R, Jenson, J.M, Grant, R.A, Keating, A.E. 登録日 2017-06-21 公開日 2018-01-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells. Proc. Natl. Acad. Sci. U.S.A., 115, 2018

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