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7XI9	Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-ordered form) Descriptor: DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*TP*CP*(C55)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... Authors: Onoda, H, Kikuchi, A, Kori, S, Yoshimi, S, Yamagata, A, Arita, K. Deposit date: 2022-04-12 Release date: 2022-11-30 Last modified: 2022-12-07 Method: ELECTRON MICROSCOPY (2.52 Å) Cite: Structural basis for activation of DNMT1. Nat Commun, 13, 2022
7XIB	Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-disordered form) Descriptor: DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*TP*CP*(C55)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... Authors: Onoda, H, Kikuchi, A, Kori, S, Yoshimi, S, Yamagata, A, Arita, K. Deposit date: 2022-04-12 Release date: 2022-11-30 Last modified: 2022-12-07 Method: ELECTRON MICROSCOPY (2.23 Å) Cite: Structural basis for activation of DNMT1. Nat Commun, 13, 2022
8C56	CpG specific M.MpeI methyltransferase crystallized in the presence of 2'-deoxy-5-methylzebularine (5mZ) and 5-methylcytosine containing dsDNA Descriptor: Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5PY)P*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(*GP*TP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*TP*G)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
8C57	CpG specific M.MpeI methyltransferase crystallized in the presence of 5,6-dihydro-5-azacytosine (converted to 5m-dhaC) and 5-methylcytosine containing dsDNA Descriptor: CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5MA)P*GP*CP*TP*GP*AP*A)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
8C58	CpG specific M.MpeI methyltransferase crystallized in the presence of 5-hydroxycytosine and 5-methylcytosine containing dsDNA Descriptor: CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5OC)P*GP*CP*TP*GP*AP*A)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
8C59	CpG specific M.MpeI methyltransferase crystallized in the presence of 5-bromocytosine (converted to 5mC) and 5-methylcytosine containing dsDNA Descriptor: CARBONATE ION, CITRIC ACID, Cytosine-specific methyltransferase, ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
8EIH	Cryo-EM structure of human DNMT3B homo-tetramer (form I) Descriptor: DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION Authors: Lu, J.W, Song, J.K. Deposit date: 2022-09-15 Release date: 2023-09-20 Last modified: 2024-04-03 Method: ELECTRON MICROSCOPY (3.04 Å) Cite: Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Nucleic Acids Res., 51, 2023
8EII	Cryo-EM structure of human DNMT3B homo-tetramer (form II) Descriptor: DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION Authors: Lu, J.W, Song, J.K. Deposit date: 2022-09-15 Release date: 2023-09-20 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Nucleic Acids Res., 51, 2023
8EIJ	Cryo-EM structure of human DNMT3B homo-trimer Descriptor: DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION Authors: Lu, J.W, Song, J.K. Deposit date: 2022-09-15 Release date: 2023-09-20 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.34 Å) Cite: Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Nucleic Acids Res., 51, 2023
8EIK	Cryo-EM structure of human DNMT3B homo-hexamer Descriptor: DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION Authors: Lu, J.W, Song, J.K. Deposit date: 2022-09-15 Release date: 2023-09-20 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.19 Å) Cite: Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Nucleic Acids Res., 51, 2023
8MHT	CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX Descriptor: 5'-D(P*CP*CP*AP*TP*GP*UP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3', CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, ... Authors: O'Gara, M, Horton, J.R, Roberts, R.J, Cheng, X. Deposit date: 1998-08-06 Release date: 1998-11-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.76 Å) Cite: Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base. Nat.Struct.Biol., 5, 1998
8T1U	Crystal structure of the DRM2-CTA DNA complex Descriptor: DNA (5'-D(P*AP*TP*TP*AP*TP*TP*AP*AP*TP*(C49)P*TP*AP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*AP*TP*TP*TP*AP*GP*AP*TP*TP*AP*AP*TP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... Authors: Chen, J, Lu, J, Song, J. Deposit date: 2023-06-03 Release date: 2023-11-22 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.91 Å) Cite: DNA conformational dynamics in the context-dependent non-CG CHH methylation by plant methyltransferase DRM2. J.Biol.Chem., 299, 2023
8TDR	Crystal structure of the methyltransferase domain of DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-04 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (3.32 Å) Cite: Crystal structure of the homo-tetrameric DNMT3A methyltransferase domain To Be Published
8TE1	Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, GLYCEROL, L(+)-TARTARIC ACID, ... Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-05 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer To Be Published
8TE3	Crystal structure of the methyltransferase domain of R882C/R676K DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-05 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Crystal structure of the homo-tetrameric DNMT3A methyltransferase domain(R882C/R676K) To Be Published
8TE4	Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-05 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer To Be Published
9MHT	CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX Descriptor: 5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*(3DR)P*GP*CP*AP*TP*GP*G)-3', CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, ... Authors: O'Gara, M, Horton, J.R, Roberts, R.J, Cheng, X. Deposit date: 1998-08-07 Release date: 1998-12-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base. Nat.Struct.Biol., 5, 1998

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