PDB: 277 件ウェブページステータス検索Chemie searchBIRD

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5VI8	Structure of a mycobacterium smegmatis transcription initiation complex with an upstream-fork promoter fragment 分子名称: 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... 著者 Hubin, E.A, Campbell, E.A, Darst, S.A. 登録日 2017-04-14 公開日 2017-04-26 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures. Nat Commun, 8, 2017
6OW3	X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter variant -1T 分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*GP*AP*TP*CP*TP*GP*AP*TP*GP*C)-3'), DNA (5'-D(P*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*TP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Shin, Y, Murakami, K.S. 登録日 2019-05-09 公開日 2019-07-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.766 Å) 主引用文献 Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase. Nucleic Acids Res., 48, 2020
3LES	2F5 Epitope scaffold ES2 分子名称: RNA polymerase sigma factor, SULFATE ION 著者 Ofek, G, Guenaga, F.J, Schief, W.R, Skinner, J, Wyatt, R, Baker, D, Kwong, P.D. 登録日 2010-01-15 公開日 2010-09-29 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Elicitation of structure-specific antibodies by epitope scaffolds. Proc.Natl.Acad.Sci.USA, 107, 2010
6KQG	Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 6 nt 分子名称: DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Zhang, Y, Li, L, Ebright, R.H. 登録日 2019-08-17 公開日 2020-03-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.783 Å) 主引用文献 RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
4OIN	Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 分子名称: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... 著者 Zhang, Y, Ebright, R.H, Arnold, E. 登録日 2014-01-20 公開日 2014-05-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
5VOI	X-ray crystal structure of bacterial RNA polymerase and pyrG promoter complex 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Murakami, K.S, Shin, Y, Turnbough Jr, C.L, Molodtsov, V. 登録日 2017-05-02 公開日 2017-05-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
2A6E	Crystal structure of the T. Thermophilus RNA polymerase holoenzyme 分子名称: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... 著者 Artsimovitch, I, Vassylyeva, M.N, Svetlov, D, Svetlov, V, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Tahirov, T.H, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-07-02 公開日 2005-09-20 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell(Cambridge,Mass.), 122, 2005
7EH0	Thermus thermophilus RNA polymerase transcription initiation complex containing a template-strand purine at position TSS-2, UpA RNA primer and CMPcPP 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (27-MER), DNA (5'-D(*CP*C*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*AP*AP*AP*G)-3'), ... 著者 Li, L, Zhang, Y. 登録日 2021-03-27 公開日 2021-07-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.808 Å) 主引用文献 Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli . Proc.Natl.Acad.Sci.USA, 118, 2021
6OVR	X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter variant -1G 分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*CP*TP*GP*AP*TP*GP*CP*AP*GP*G)-3'), DNA (5'-D(P*GP*GP*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*GP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Shin, Y, Murakami, K.S. 登録日 2019-05-08 公開日 2019-07-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.843 Å) 主引用文献 Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase. Nucleic Acids Res., 48, 2020
6KQL	Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 4 nt 分子名称: DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Zhang, Y, Li, L, Ebright, R.H. 登録日 2019-08-18 公開日 2020-03-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
1KU2	Crystal Structure of Thermus aquaticus RNA Polymerase Sigma Subunit Fragment Containing Regions 1.2 to 3.1 分子名称: SULFATE ION, sigma factor sigA 著者 Campbell, E.A, Muzzin, O, Chlenov, M, Sun, J.L, Olson, C.A, Weinman, O, Trester-Zedlitz, M.L, Darst, S.A. 登録日 2002-01-21 公開日 2002-04-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of the bacterial RNA polymerase promoter specificity sigma subunit. Mol.Cell, 9, 2002
7EH1	Thermus thermophilus transcription initiation complex containing a template-strand purine at position TSS-2, GpG RNA primer, and CMPcPP 分子名称: 1,4-BUTANEDIOL, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (27-MER), ... 著者 Li, L, Zhang, Y. 登録日 2021-03-27 公開日 2021-07-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli . Proc.Natl.Acad.Sci.USA, 118, 2021
7MKJ	Cryo-EM structure of Escherichia coli RNA polymerase bound to T7A1 promoter DNA 分子名称: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Saecker, R.M, Darst, S.A, Chen, J. 登録日 2021-04-23 公開日 2021-09-29 最終更新日 2021-10-13 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
4Q4Z	Thermus thermophilus RNA polymerase de novo transcription initiation complex 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ADENOSINE-5'-TRIPHOSPHATE, DNA (25-MER), ... 著者 Murakami, K.S. 登録日 2014-04-15 公開日 2014-07-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme. J.Biol.Chem., 289, 2014
4G7H	Crystal structure of Thermus thermophilus transcription initiation complex 分子名称: 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', DNA-directed RNA polymerase subunit alpha, ... 著者 Zhang, Y, Ebright, R.H. 登録日 2012-07-20 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis of transcription initiation. Science, 338, 2012
6VVT	Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and antibiotic Sorangicin 分子名称: 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... 著者 Lilic, M, Darst, S.A, Campbell, E.A. 登録日 2020-02-18 公開日 2020-10-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.901 Å) 主引用文献 The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
6P71	X-ray crystal structure of a bacterial reiterative transcription complex of pyrBI promoter 分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*CP*GP*AP*GP*CP*CP*GP*GP*GP*A)-3'), DNA (5'-D(P*CP*TP*CP*CP*CP*GP*GP*CP*AP*AP*AP*TP*TP*GP*T)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Shin, Y, Murakami, K.S. 登録日 2019-06-04 公開日 2019-07-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.92 Å) 主引用文献 Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase. Nucleic Acids Res., 48, 2020
7SZK	Cryo-EM structure of 27a bound to E. coli RNAP and rrnBP1 promoter complex 分子名称: (2S,7R,7aR,13aP,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,21,23-trihydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-12-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1,6,15-trioxo-1,2,7,7a-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate, DNA (5'-D(P*CP*TP*CP*GP*TP*AP*GP*AP*GP*TP*CP*CP*GP*TP*GP*TP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Shin, Y, Murakami, K.S. 登録日 2021-11-28 公開日 2022-07-13 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis. Acs Infect Dis., 8, 2022
7KIF	Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 transcription factor 分子名称: DNA (55-MER), DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Lilic, M, Darst, S.A, Campbell, E.A. 登録日 2020-10-23 公開日 2021-04-21 最終更新日 2021-11-03 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
8GZH	Cryo-EM structure of Synechocystis sp. PCC 6803 CTP-bound RPitc 分子名称: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 You, L.L, Shen, L.Q, Zhang, Y. 登録日 2022-09-27 公開日 2023-04-19 実験手法 ELECTRON MICROSCOPY (2.96 Å) 主引用文献 Cryo-EM structure of Synechocystis sp. PCC 6803 CTP-bound RPitc Proc.Natl.Acad.Sci.USA, 2023
4G7O	Crystal structure of Thermus thermophilus transcription initiation complex containing 2 nt of RNA 分子名称: 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', 5'-R(*GP*A)-3', ... 著者 Zhang, Y, Ebright, R.H. 登録日 2012-07-20 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.993 Å) 主引用文献 Structural basis of transcription initiation. Science, 338, 2012
6CUU	Thermus thermophiles RNA polymerase in complex with promoter DNA and antibiotic Kanglemycin A 分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*CP*TP*CP*TP*GP*AP*TP*GP*CP*A)-3'), DNA (5'-D(P*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Molodtsov, V, Murakami, K.S. 登録日 2018-03-26 公開日 2018-07-25 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.994 Å) 主引用文献 Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. Mol. Cell, 72, 2018
6OVY	X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter variant -1C 分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*TP*CP*TP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*CP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Shin, Y, Murakami, K.S. 登録日 2019-05-08 公開日 2019-07-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.999 Å) 主引用文献 Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase. Nucleic Acids Res., 48, 2020
6WOY	Thermus thermophilus RNA polymerase initially transcribing complex with 3'dCTP 分子名称: 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*G)-3'), ... 著者 Shin, Y, Murakami, K.S. 登録日 2020-04-26 公開日 2020-06-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases. Nat Commun, 12, 2021
7RDQ	Cryo-EM structure of Thermus thermophilus reiterative transcription complex with 11nt oligo-G RNA 分子名称: DNA (31-MER) nontemplate strand, DNA (31-MER) template strand, DNA-directed RNA polymerase subunit alpha, ... 著者 Liu, Y, Ebright, R.H. 登録日 2021-07-10 公開日 2022-02-02 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022

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