6UU7
| E. coli sigma-S transcription initiation complex with a 6-nt RNA and an NTP ("Old" crystal soaked with UTP, CTP, ddGTP, and dinucleotide ApG for 30 minutes) | 分子名称: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Zuo, Y, De, S, Steitz, T.A. | 登録日 | 2019-10-30 | 公開日 | 2020-08-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | 主引用文献 | Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
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7CKQ
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5UH9
| Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 2nt RNA | 分子名称: | DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... | 著者 | Lin, W, Das, K, Feng, Y, Ebright, R.H. | 登録日 | 2017-01-11 | 公開日 | 2017-04-12 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (4.402 Å) | 主引用文献 | Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
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6UU2
| E. coli sigma-S transcription initiation complex with 3-nt RNA ("Old" crystal soaked with GTP and ATP for 30 minutes) | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Zuo, Y, De, S, Steitz, T.A. | 登録日 | 2019-10-30 | 公開日 | 2020-08-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (4.404 Å) | 主引用文献 | Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
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5I2D
| Crystal structure of T. thermophilus TTHB099 class II transcription activation complex: TAP-RPo | 分子名称: | DNA (72-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Feng, Y, Zhang, Y, Ebright, R.H. | 登録日 | 2016-02-08 | 公開日 | 2016-06-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (4.405 Å) | 主引用文献 | Structural basis of transcription activation. Science, 352, 2016
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6WMT
| F. tularensis RNAPs70-(MglA-SspA)-ppGpp-PigR-iglA DNA complex | 分子名称: | DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ... | 著者 | Travis, B.A, Brennan, R.G, Schumacher, M.A. | 登録日 | 2020-04-21 | 公開日 | 2020-11-11 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.43 Å) | 主引用文献 | Structural Basis for Virulence Activation of Francisella tularensis. Mol.Cell, 81, 2021
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8H3V
| Cryo-EM structure of the full transcription activation complex NtcA-NtcB-TAC | 分子名称: | DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. | 登録日 | 2022-10-09 | 公開日 | 2023-10-04 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024
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7BEF
| Structures of class II bacterial transcription complexes | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Hao, M, Ye, F.Z, Zhang, X.D. | 登録日 | 2020-12-23 | 公開日 | 2021-12-01 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structures of Class I and Class II Transcription Complexes Reveal the Molecular Basis of RamA-Dependent Transcription Activation. Adv Sci, 9, 2022
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5W1T
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6PB5
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7W5W
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7VWY
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4XLQ
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5IPN
| SigmaS-transcription initiation complex with 4-nt nascent RNA | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Liu, B, Zuo, Y, Steitz, T.A. | 登録日 | 2016-03-09 | 公開日 | 2016-03-30 | 最終更新日 | 2016-06-22 | 実験手法 | X-RAY DIFFRACTION (4.61 Å) | 主引用文献 | Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
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6C06
| Mycobacterium tuberculosis RNAP Holo/RbpA/Fidaxomicin | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J, Lilic, M. | 登録日 | 2017-12-27 | 公開日 | 2018-03-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (5.15 Å) | 主引用文献 | Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts. Elife, 7, 2018
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6C05
| Mycobacterium tuberculosis RNAP Holo/RbpA in relaxed state | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J, Lilic, M. | 登録日 | 2017-12-27 | 公開日 | 2018-03-28 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (5.15 Å) | 主引用文献 | Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts. Elife, 7, 2018
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6UU9
| E. coli mutant sigma-S transcription initiation complex with an 8-nt RNA ("Fresh" mutant crystal soaked with GTP, UTP, CTP, and ddATP for 30 minutes) | 分子名称: | 2',3'-DIDEOXYADENOSINE-5'-MONOPHOSPHATE, DIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, ... | 著者 | Zuo, Y, De, S, Steitz, T.A. | 登録日 | 2019-10-30 | 公開日 | 2020-08-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (5.4 Å) | 主引用文献 | Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
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6UU5
| E. coli sigma-S transcription initiation complex with a 6-nt RNA ("Old" crystal soaked with GTP, UTP, CTP, and dinucleotide GpA for 30 minutes) | 分子名称: | DIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Zuo, Y, De, S, Steitz, T.A. | 登録日 | 2019-10-30 | 公開日 | 2020-08-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (5.403 Å) | 主引用文献 | Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
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4YLP
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4YLN
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6CA0
| Cryo-EM structure of E. coli RNAP sigma70 open complex | 分子名称: | DNA (35-MER), DNA (45-MER), DNA (5'-D(P*GP*CP*CP*GP*CP*GP*TP*CP*AP*GP*A)-3'), ... | 著者 | Narayanan, A, Vago, F, Li, K, Qayyum, M.Z, Yernool, D, Jiang, W, Murakami, K.S. | 登録日 | 2018-01-29 | 公開日 | 2018-02-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (5.75 Å) | 主引用文献 | Cryo-EM structure ofEscherichia colisigma70RNA polymerase and promoter DNA complex revealed a role of sigma non-conserved region during the open complex formation. J. Biol. Chem., 293, 2018
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7F0R
| Cryo-EM structure of Pseudomonas aeruginosa SutA transcription activation complex | 分子名称: | DNA (70-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | He, D.W, You, L.L, Zhang, Y. | 登録日 | 2021-06-06 | 公開日 | 2022-07-27 | 最終更新日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | 主引用文献 | Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding. Nat Commun, 13, 2022
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4YLO
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1L9Z
| Thermus aquaticus RNA Polymerase Holoenzyme/Fork-Junction Promoter DNA Complex at 6.5 A Resolution | 分子名称: | MAGNESIUM ION, RNA POLYMERASE, ALPHA SUBUNIT, ... | 著者 | Murakami, K.S, Masuda, S, Campbell, E.A, Muzzin, O, Darst, S.A. | 登録日 | 2002-03-27 | 公開日 | 2002-05-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (6.5 Å) | 主引用文献 | Structural basis of transcription initiation: an RNA polymerase holoenzyme-DNA complex. Science, 296, 2002
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6N4C
| EM structure of the DNA wrapping in bacterial open transcription initiation complex | 分子名称: | DNA (94-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Florez-Ariza, A, Cassago, A, de Oliveira, P.S.L, Guerra, D.G, Portugal, R.V. | 登録日 | 2018-11-19 | 公開日 | 2020-05-27 | 実験手法 | ELECTRON MICROSCOPY (17 Å) | 主引用文献 | Interactions of Upstream and Downstream Promoter Regions with RNA Polymerase are Energetically Coupled and a Target of Regulation in Transcription Initiation Biorxiv, 2020
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