PDB: 277 件ウェブページステータス検索Chemie searchBIRD

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4ZH4	Crystal structure of Escherichia coli RNA polymerase in complex with CBRP18 分子名称: 5-(4-fluorophenyl)-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-pyrazole, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Feng, Y, Ebright, R.H. 登録日 2015-04-24 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.993 Å) 主引用文献 Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles. Structure, 23, 2015
7VWZ	Cryo-EM structure of Rob-dependent transcription activation complex in a unique conformation 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Lin, W, Feng, Y, Shi, J. 登録日 2021-11-12 公開日 2022-06-08 最終更新日 2022-06-22 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator. Nucleic Acids Res., 50, 2022
4XLN	Crystal structure of T. aquaticus transcription initiation complex containing bubble promoter and RNA 分子名称: DNA (48-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-13 公開日 2015-09-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Structure of a bacterial RNA polymerase holoenzyme open promoter complex. Elife, 4, 2015
1L9U	THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME AT 4 A RESOLUTION 分子名称: MAGNESIUM ION, RNA POLYMERASE, ALPHA SUBUNIT, ... 著者 Murakami, K.S, Masuda, S, Darst, S.A. 登録日 2002-03-26 公開日 2002-05-22 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 A resolution. Science, 296, 2002
4XLP	Crystal structure of T.aquaticus transcription initiation complex containing upstream fork promoter 分子名称: DNA (25-MER), DNA (30-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-13 公開日 2015-09-23 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Structure of a bacterial RNA polymerase holoenzyme open promoter complex. Elife, 4, 2015
6UUA	E. coli sigma-S transcription initiation complex with a mismatching CTP ("Fresh" crystal soaked with CTP for 2 hours) 分子名称: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.002 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UU3	E. coli sigma-S transcription initiation complex with a 4-nt RNA and a CTP ("Old" crystal soaked with GTP, ATP, CTP, and ddTTP for 30 minutes) 分子名称: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.002 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
5XJ0	T. thermophilus RNA polymerase holoenzyme bound with gp39 and gp76 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Ooi, W.Y, Murayama, Y, Mekler, V, Minakhin, L, Severinov, K, Yokoyama, S, Sekine, S. 登録日 2017-04-28 公開日 2017-12-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (4.004 Å) 主引用文献 A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation Nucleic Acids Res., 46, 2018
4XSY	Crystal structure of CBR 9379 bound to Escherichia coli RNA polymerase holoenzyme 分子名称: 3-{[(2,6-dichlorophenyl)carbamoyl]amino}-N-hydroxy-N'-phenyl-5-(trifluoromethyl)benzenecarboximidamide, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-22 公開日 2015-07-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (4.007 Å) 主引用文献 CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition. Proc.Natl.Acad.Sci.USA, 112, 2015
4XLS	Crystal structure of T. aquaticus transcription initiation complex with CarD containing upstream fork promoter. 分子名称: CarD-like transcriptional regulator, DNA (30-MER), DNA (5'-D(P*GP*CP*AP*CP*AP*AP*TP*TP*TP*AP*AP*CP*AP*CP*TP*TP*TP*TP*GP*TP*CP*AP*AP*G)-3'), ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-13 公開日 2015-09-23 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (4.01 Å) 主引用文献 CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex. Elife, 4, 2015
5UHD	Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 4nt RNA in complex with Rifampin 分子名称: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Lin, W, Das, K, Feng, Y, Ebright, R.H. 登録日 2017-01-11 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.01 Å) 主引用文献 Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
6VJS	Escherichia coli RNA polymerase and ureidothiophene-2-carboxylic acid complex 分子名称: 3-{[benzyl(ethyl)carbamoyl]amino}-5-(4-phenoxyphenyl)thiophene-2-carboxylic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Murakami, K.S, Molodtsov, V. 登録日 2020-01-17 公開日 2020-10-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.02 Å) 主引用文献 Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus -Based Wound Infection Model in SKH1 Mice. Acs Infect Dis., 6, 2020
5UHE	Crystal structure of Mycobacterium tuberculosis transcription initiation complex in complex with D-AAP1 分子名称: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Lin, W, Das, K, Feng, Y, Ebright, R.H. 登録日 2017-01-11 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.039 Å) 主引用文献 Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
7VF9	Cryo-EM structure of Pseudomonas aeruginosa RNAP sigmaS holoenzyme complexes 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 He, D.W, You, L.L, Zhang, Y. 登録日 2021-09-10 公開日 2022-07-27 最終更新日 2023-08-09 実験手法 ELECTRON MICROSCOPY (4.04 Å) 主引用文献 Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding. Nat Commun, 13, 2022
6P1K	Cryo-EM structure of Escherichia coli sigma70 bound RNAP polymerase holoenzyme 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. 登録日 2019-05-20 公開日 2020-02-26 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.05 Å) 主引用文献 E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation. Elife, 8, 2019
6UTX	E. coli sigma-S transcription initiation complex with an empty bubble ("Old" crystal) 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.05 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6JNX	Cryo-EM structure of a Q-engaged arrested complex 分子名称: Antiterminator Q protein, DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Feng, Y, Shi, J. 登録日 2019-03-18 公開日 2019-06-12 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.08 Å) 主引用文献 Structural basis of Q-dependent transcription antitermination. Nat Commun, 10, 2019
4ZH3	Crystal structure of Escherichia coli RNA polymerase in complex with CBRH16-Br 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Feng, Y, Ebright, R.H. 登録日 2015-04-24 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (4.082 Å) 主引用文献 Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles. Structure, 23, 2015
6UUC	E. coli sigma-S transcription initiation complex with a 3-nt RNA and a mismatching ATP ("Fresh" crystal soaked with ATP for 2 hours) 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.096 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UU1	E. coli sigma-S transcription initiation complex with a 4-nt RNA and a CTP ("Fresh" crystal soaked with CTP, GTP, and ddTTP for 30 minutes) 分子名称: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.097 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
8AD1	RNA polymerase at U-rich pause bound to RNA putL triple mutant - pause prone, closed clamp state 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Dey, S, Weixlbaumer, A. 登録日 2022-07-07 公開日 2022-10-19 最終更新日 2022-11-02 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural insights into RNA-mediated transcription regulation in bacteria. Mol.Cell, 82, 2022
6XH8	CueR-transcription activation complex with RNA transcript 分子名称: COPPER (II) ION, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Liu, B, Shi, W, Yang, Y. 登録日 2020-06-18 公開日 2021-04-14 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural basis of copper-efflux-regulator-dependent transcription activation. Iscience, 24, 2021
5UAH	Escherichia coli RNA polymerase and Rifampin complex, RpoB D516V mutant 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S. 登録日 2016-12-19 公開日 2017-01-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.1 Å) 主引用文献 Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis. Mol. Microbiol., 103, 2017
6CUX	Escherichia coli RpoB S531L mutant RNA polymerase holoenzyme in complex with Kanglemycin A 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Molodtsov, V, Murakami, K.S. 登録日 2018-03-26 公開日 2018-07-25 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (4.104 Å) 主引用文献 Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. Mol. Cell, 72, 2018
7VPZ	Cryo-EM structure of Streptomyces coelicolor transcription initial complex with one Zur dimer 分子名称: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Yang, X, Zheng, J. 登録日 2021-10-18 公開日 2022-08-03 最終更新日 2022-08-24 実験手法 ELECTRON MICROSCOPY (4.14 Å) 主引用文献 Structural basis of Streptomyces transcription activation by zinc uptake regulator. Nucleic Acids Res., 50, 2022

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