PDB: 291 resultsInfo pagesStatus searchChemie searchBIRD

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3KD5	Closed ternary complex of an RB69 gp43 fingers domain mutant complexed with an acyclic GMP terminated primer template pair and phosphonoformic acid. Descriptor: DNA (5'-D(*CP*GP*TP*CP*TP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*AP*(4DG))-3'), DNA polymerase, ... Authors: Zahn, K.E, Doublie, S. Deposit date: 2009-10-22 Release date: 2011-04-13 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase. J.Biol.Chem., 286, 2011
3KD1	Closed binary complex of an RB69 gp43 fingers domain mutant complexed with an acyclic GMP terminated primer template pair. Descriptor: DNA (5'-D(*CP*GP*TP*CP*TP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*AP*(4DG))-3'), DNA polymerase, ... Authors: Zahn, K.E, Doublie, S. Deposit date: 2009-10-22 Release date: 2011-04-13 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.66 Å) Cite: Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase. J.Biol.Chem., 286, 2011
3L8B	Crystal structure of a replicative DNA polymerase bound to the oxidized guanine lesion guanidinohydantoin Descriptor: DNA (5'-D(*AP*C*TP*(G35)P*TP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*A)-3'), DNA polymerase, ... Authors: Aller, P, Ye, Y, Wallace, S.S, Burrows, C.J, Doublie, S. Deposit date: 2009-12-30 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal structure of a replicative DNA polymerase bound to the oxidized guanine lesion guanidinohydantoin. Biochemistry, 49, 2010
3LDS	Crystal structure of RB69 gp43 with DNA and dATP opposite 8-oxoG Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*(8OG)P*CP*TP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*AP*(DDG))-3'), ... Authors: Hogg, M, Midkiff, J, Rudnicki, J, Reha-Krantz, L, Doublie, S, Wallace, S.S. Deposit date: 2010-01-13 Release date: 2010-06-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3 Å) Cite: Kinetics of mismatch formation opposite lesions by the replicative DNA polymerase from bacteriophage RB69. Biochemistry, 49, 2010
8B9B	S. cerevisiae replisome + Ctf4, bound by pol alpha. Complex engaged with a fork DNA substrate containing a 60 nucleotide lagging strand. Descriptor: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ... Authors: Jones, M.L, Yeeles, J.T.P. Deposit date: 2022-10-05 Release date: 2023-08-09 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
8B9A	S. cerevisiae replisome + Ctf4, bound by pol alpha primase. Complex engaged with a fork DNA substrate containing a 60 nucleotide lagging strand. Descriptor: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ... Authors: Jones, M.L, Yeeles, J.T.P. Deposit date: 2022-10-05 Release date: 2023-08-09 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
8B9D	Human replisome bound by Pol Alpha Descriptor: Cell division control protein 45 homolog, Claspin, DNA Molecule, ... Authors: Jones, M.L, Yeeles, J.T.P. Deposit date: 2022-10-05 Release date: 2023-08-09 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
8B9C	S. cerevisiae pol alpha - replisome complex Descriptor: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ... Authors: Jones, M.L, Yeeles, J.T.P. Deposit date: 2022-10-05 Release date: 2023-08-09 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
8B67	The crystal structure of M644G variant of DNA Pol Epsilon containing CTP in the polymerase active site Descriptor: ACETATE ION, CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-26 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8B6K	The crystal structure of M644G variant of DNA Pol Epsilon containing dCTP in the polymerase active site Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-27 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8B7E	The crystal structure of N828V variant of DNA Pol Epsilon containing UTP in the polymerase active site Descriptor: CALCIUM ION, DNA polymerase epsilon catalytic subunit A, GLYCEROL, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-29 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8B77	The crystal structure of N828V variant of DNA Pol Epsilon containing dATP in the polymerase active site Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-29 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8B76	The crystal structure of M644G variant of DNA Pol Epsilon containing dTTP in the polymerase active site Descriptor: ACETATE ION, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-28 Release date: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8B79	The crystal structure of M644G variant of DNA Pol Epsilon containing UTP in the polymerase active site Descriptor: ACETATE ION, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-29 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.65 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8D0K	Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template - PRIM2C advanced PIC Descriptor: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... Authors: He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C. Deposit date: 2022-05-26 Release date: 2022-06-22 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (4.27 Å) Cite: Structures of the human CST-Pol alpha-primase complex bound to telomere templates. Nature, 608, 2022
8D0B	Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template Descriptor: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... Authors: He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C. Deposit date: 2022-05-26 Release date: 2022-06-22 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (3.43 Å) Cite: Structures of the human CST-Pol alpha-primase complex bound to telomere templates. Nature, 608, 2022
8D96	Human DNA polymerase alpha/primase elongation complex I bound to primer/template Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*AP*AP*TP*GP*GP*TP*CP*GP*TP*GP*CP*CP*GP*CP*CP*AP*AP*TP*AP*A)-3'), DNA polymerase alpha catalytic subunit, ... Authors: He, Q, Baranovskiy, A, Lim, C, Tahirov, T. Deposit date: 2022-06-09 Release date: 2023-04-19 Last modified: 2023-05-31 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Structures of human primosome elongation complexes. Nat.Struct.Mol.Biol., 30, 2023
8D9D	Human DNA polymerase-alpha/primase elongation complex II bound to primer/template Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*GP*GP*TP*CP*GP*TP*GP*CP*CP*GP*CP*CP*AP*AP*TP*AP*A)-3'), DNA polymerase alpha catalytic subunit, ... Authors: He, Q, Baranovskiy, A, Lim, C, Tahirov, T. Deposit date: 2022-06-09 Release date: 2023-04-19 Last modified: 2023-05-31 Method: ELECTRON MICROSCOPY (3.59 Å) Cite: Structures of human primosome elongation complexes. Nat.Struct.Mol.Biol., 30, 2023
8WPP	Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with endogenous DNA Descriptor: A22R DNA polymerase processivity factor, DNA polymerase, E4R Uracil-DNA glycosylase, ... Authors: Wang, X, Li, N, Gao, N. Deposit date: 2023-10-10 Release date: 2023-11-29 Last modified: 2023-12-27 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5. Mol.Cell, 83, 2023
8UCV	Complete DNA termination subcomplex 1 of Xenopus laevis DNA polymerase alpha-primase Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA primase large subunit, ... Authors: Mullins, E.A, Chazin, W.C, Eichman, B.F. Deposit date: 2023-09-27 Release date: 2023-10-11 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.81 Å) Cite: A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 2024
8UCW	Complete DNA termination subcomplex 2 of Xenopus laevis DNA polymerase alpha-primase Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA template, ... Authors: Mullins, E.A, Chazin, W.C, Eichman, B.F. Deposit date: 2023-09-27 Release date: 2023-10-11 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.64 Å) Cite: A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 2024
8WPK	Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with exgenous DNA Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA polymerase, DNA polymerase processivity factor, ... Authors: Wang, X, Li, N, Gao, N. Deposit date: 2023-10-10 Release date: 2023-11-29 Last modified: 2023-12-27 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5. Mol.Cell, 83, 2023
8UCU	Partial DNA termination subcomplex of Xenopus laevis DNA polymerase alpha-primase Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA template, ... Authors: Mullins, E.A, Chazin, W.J, Eichman, B.F. Deposit date: 2023-09-27 Release date: 2023-10-11 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 2024
8WPE	Structure of monkeypox virus polymerase complex F8-A22-E4-H5 (tag-free A22) with exogenous DNA Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, A22R DNA polymerase processivity factor, DNA polymerase, ... Authors: Wang, X, Li, N, Gao, N. Deposit date: 2023-10-10 Release date: 2023-11-29 Last modified: 2023-12-27 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5. Mol.Cell, 83, 2023
8WPF	Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with exogenous DNA bearing one abasic site Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, A22R DNA polymerase processivity factor, DNA polymerase, ... Authors: Wang, X, Li, N, Gao, N. Deposit date: 2023-10-10 Release date: 2023-11-29 Last modified: 2023-12-27 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5. Mol.Cell, 83, 2023

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