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1U9V	Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABE854 Descriptor: 6-(CYCLOHEXYLAMINO)-9-[2-(4-METHYLPIPERAZIN-1-YL)-ETHYL]-9H-PURINE-2-CARBONITRILE, Cathepsin K Authors: Cowan-Jacob, S.W. Deposit date: 2004-08-11 Release date: 2005-08-11 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K J.Med.Chem., 47, 2004
1U9Q	Crystal structure of cruzain bound to an alpha-ketoester Descriptor: [1-(1-METHYL-4,5-DIOXO-PENT-2-ENYLCARBAMOYL)-2-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER, cruzipain Authors: Lange, M, Weston, S.G, Cheng, H, Culliane, M, Fiorey, M.M, Grisostomi, C, Hardy, L.W, Hartstough, D.S, Pallai, P.V, Tilton, R.F, Baldino, C.M, Brinen, L.S, Engel, J.C, Choe, Y, Price, M.S, Craik, C.S. Deposit date: 2004-08-10 Release date: 2005-03-29 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease Bioorg.Med.Chem., 13, 2005
1TU6	Cathepsin K complexed with a ketoamide inhibitor Descriptor: Cathepsin K, SULFATE ION, [1-(4-FLUOROBENZYL)CYCLOBUTYL]METHYL (1S)-1-[OXO(1H-PYRAZOL-5-YLAMINO)ACETYL]PENTYLCARBAMATE Authors: Barrett, D.G, Catalano, J.G, Deaton, D.N, Hassell, A.M, Long, S.T, Miller, A.B, Miller, L.R, Shewchuk, L.M, Wells-Knecht, K.J, Wright, L.L. Deposit date: 2004-06-24 Release date: 2004-09-21 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with improved pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions BIOORG.MED.CHEM.LETT., 14, 2004
1THE	CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN Descriptor: Cathepsin B, amino{[(4S)-4-{[(benzyloxy)carbonyl]amino}-5-{[(2S)-1-(benzyloxy)-4-chloro-3-oxobutan-2-yl]amino}-5-oxopentyl]amino}methaniminium Authors: Huber, C.P, Jia, Z. Deposit date: 1995-09-15 Release date: 1996-03-10 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design. J.Biol.Chem., 270, 1995
1STF	THE REFINED 2.4 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF RECOMBINANT HUMAN STEFIN B IN COMPLEX WITH THE CYSTEINE PROTEINASE PAPAIN: A NOVEL TYPE OF PROTEINASE INHIBITOR INTERACTION Descriptor: PAPAIN, STEFIN B (CYSTATIN B) Authors: Stubbs, M.T, Laber, B, Bode, W. Deposit date: 1993-04-21 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.37 Å) Cite: The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction. EMBO J., 9, 1990
1SP4	Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the whole active site cleft Descriptor: Cathepsin B, methyl N-[(2S)-4-{[(1S)-1-{[(2S)-2-carboxypyrrolidin-1-yl]carbonyl}-3-methylbutyl]amino}-2-hydroxy-4-oxobutanoyl]-L-leucylglycylglycinate Authors: Stern, I, Schaschke, N, Moroder, L, Turk, D. Deposit date: 2004-03-16 Release date: 2004-05-04 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft. Biochem.J., 381, 2004
1SNK	Cathepsin K complexed with carbamate derivatized norleucine aldehyde Descriptor: Cathepsin K, N2-({[(4-BROMOPHENYL)METHYL]OXY}CARBONYL)-N1-[(1S)-1-FORMYLPENTYL]-L-LEUCINAMIDE, SULFATE ION Authors: Boros, E.E, Deaton, D.N, Hassell, A.M, McFadyen, R.B, Miller, A.B, Miller, L.R, Shewchuk, L.M, Thompson, J.B, Willard Jr, D.H, Wright, L.L. Deposit date: 2004-03-11 Release date: 2004-06-22 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Exploration of the P(2)-P(3) SAR of aldehyde cathepsin K inhibitors Bioorg.Med.Chem.Lett., 14, 2004
1S4V	The 2.0 A crystal structure of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm Descriptor: DVA-LEU-LYS-0QE peptide, SULFATE ION, cysteine endopeptidase Authors: Than, M.E, Helm, M, Simpson, D.J, Lottspeich, F, Huber, R, Gietl, C. Deposit date: 2004-01-19 Release date: 2004-03-16 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2 Å) Cite: The 2.0 A crystal structure and substrate specificity of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm. J.Mol.Biol., 336, 2004
1QDQ	X-RAY CRYSTAL STRUCTURE OF BOVINE CATHEPSIN B-CA074 COMPLEX Descriptor: CATHEPSIN B, [PROPYLAMINO-3-HYDROXY-BUTAN-1,4-DIONYL]-ISOLEUCYL-PROLINE Authors: Yamamoto, A. Deposit date: 1999-07-10 Release date: 2000-07-10 Last modified: 2018-01-31 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Substrate specificity of bovine cathepsin B and its inhibition by CA074, based on crystal structure refinement of the complex. J.Biochem.(Tokyo), 127, 2000
1Q6K	Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate Descriptor: Cathepsin K, SULFATE ION, TERT-BUTYL(1S)-1-CYCLOHEXYL-2-OXOETHYLCARBAMATE Authors: Catalano, J.G, Deaton, D.N, Furfine, E.S, Hassell, A.M, McFadyen, R.B, Miller, A.B, Miller, L.R, Shewchuk, L.M, Willard, D.H, Wright, L.L. Deposit date: 2003-08-13 Release date: 2004-03-16 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Exploration of the P1 SAR of aldehyde cathepsin K inhibitors Bioorg.Med.Chem.Lett., 14, 2004
1PPP	CRYSTAL STRUCTURE OF PAPAIN-E64-C COMPLEX. BINDING DIVERSITY OF E64-C TO PAPAIN S2 AND S3 SUBSITES Descriptor: METHANOL, N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-2-METHYL-BUTANE, PAPAIN Authors: Ishida, T. Deposit date: 1993-03-17 Release date: 1994-01-31 Last modified: 2012-05-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of papain-E64-c complex. Binding diversity of E64-c to papain S2 and S3 subsites. Biochem.J., 287, 1992
1PPO	DETERMINATION OF THE STRUCTURE OF PAPAYA PROTEASE OMEGA Descriptor: MERCURY (II) ION, PROTEASE OMEGA Authors: Pickersgill, R.W, Rizkallah, P.J, Harris, G.W, Goodenough, P.W. Deposit date: 1991-07-12 Release date: 1993-10-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Determination of the Structure of Papaya Protease Omega Acta Crystallogr.,Sect.B, 47, 1991
1PPN	STRUCTURE OF MONOCLINIC PAPAIN AT 1.60 ANGSTROMS RESOLUTION Descriptor: METHANOL, PAPAIN, UNKNOWN LIGAND Authors: Pickersgill, R.W, Harris, G.W, Garman, E. Deposit date: 1991-10-25 Release date: 1994-01-31 Last modified: 2015-04-08 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structure of Monoclinic Papain at 1.60 Angstroms Resolution Acta Crystallogr.,Sect.B, 48, 1992
1PPD	RESTRAINED LEAST-SQUARES REFINEMENT OF THE SULFHYDRYL PROTEASE PAPAIN TO 2.0 ANGSTROMS Descriptor: 2-HYDROXYETHYL-THIOPAPAIN, BETA-MERCAPTOETHANOL Authors: Jansonius, J.N. Deposit date: 1984-11-06 Release date: 1985-01-02 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Restrained Least-Squares Refinement of the Sulfhydryl Protease Papain to 2.0 Angstroms Acta Crystallogr.,Sect.A, 40, 1984
1POP	X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PAPAIN-LEUPEPTIN COMPLEX Descriptor: LEUPEPTIN, METHANOL, PAPAIN Authors: Schroder, E, Crawford, C. Deposit date: 1993-06-24 Release date: 1993-10-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: X-ray crystallographic structure of a papain-leupeptin complex. FEBS Lett., 315, 1993
1PIP	CRYSTAL STRUCTURE OF PAPAIN-SUCCINYL-GLN-VAL-VAL-ALA-ALA-P-NITROANILIDE COMPLEX AT 1.7 ANGSTROMS RESOLUTION: NONCOVALENT BINDING MODE OF A COMMON SEQUENCE OF ENDOGENOUS THIOL PROTEASE INHIBITORS Descriptor: Papain, SUCCINYL-GLN-VAL-VAL-ALA-ALA-P-NITROANILIDE Authors: Yamamoto, A, Tomoo, K, Doi, M, Ohishi, H, Inoue, M, Ishida, T, Yamamoto, D, Tsuboi, S, Okamoto, H, Okada, Y. Deposit date: 1992-10-03 Release date: 1993-10-31 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of papain-succinyl-Gln-Val-Val-Ala-Ala-p-nitroanilide complex at 1.7-A resolution: noncovalent binding mode of a common sequence of endogenous thiol protease inhibitors. Biochemistry, 31, 1992
1PE6	REFINED X-RAY STRUCTURE OF PAPAIN(DOT)E-64-C COMPLEX AT 2.1-ANGSTROMS RESOLUTION Descriptor: METHANOL, N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-2-METHYL-BUTANE, PAPAIN Authors: Yamamoto, D, Matsumoto, K, Ohishi, H, Ishida, T, Inoue, M, Kitamura, K, Mizuno, H. Deposit date: 1991-05-14 Release date: 1993-04-15 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Refined x-ray structure of papain.E-64-c complex at 2.1-A resolution. J.Biol.Chem., 266, 1991
1PCI	PROCARICAIN Descriptor: PROCARICAIN Authors: Groves, M.R, Taylor, M.A.J, Scott, M, Cummings, N.J, Pickersgill, R.W, Jenkins, J.A. Deposit date: 1996-06-28 Release date: 1997-04-01 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3.2 Å) Cite: The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft. Structure, 4, 1996
1PBH	CRYSTAL STRUCTURE OF HUMAN RECOMBINANT PROCATHEPSIN B AT 3.2 ANGSTROM RESOLUTION Descriptor: PROCATHEPSIN B Authors: Podobnik, M, Turk, D. Deposit date: 1997-02-14 Release date: 1998-02-25 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Crystal structures of human procathepsin B at 3.2 and 3.3 Angstroms resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide. FEBS Lett., 384, 1996
1PAD	Binding of chloromethyl ketone substrate analogues to crystalline papain Descriptor: ACETYL-ALA-ALA-PHE-ALA-CHLOROMETHYLKETONE INHIBITOR, PAPAIN Authors: Drenth, J, Kalk, K.H, Swen, H.M. Deposit date: 1976-11-01 Release date: 1977-04-12 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Binding of chloromethyl ketone substrate analogues to crystalline papain. Biochemistry, 15, 1976
1O0E	1.9 Angstrom Crystal Structure of a plant cysteine protease Ervatamin C Descriptor: Ervatamin C, THIOSULFATE Authors: Thakurta, P.G, Chakrabarti, C, Biswas, S, Dattagupta, J.K. Deposit date: 2003-02-21 Release date: 2004-03-02 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Basis of the Unusual Stability and Substrate Specificity of Ervatamin C, a Plant Cysteine Protease from Ervatamia coronaria Biochemistry, 43, 2004
1NQC	Crystal structures of Cathepsin S inhibitor complexes Descriptor: Cathepsin S, N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE Authors: Pauly, T.A, Sulea, T, Ammirati, M, Sivaraman, J, Danley, D.E, Griffor, M.C, Kamath, A.V, Wang, I.K, Laird, E.R, Menard, R, Cygler, M, Rath, V.L. Deposit date: 2003-01-21 Release date: 2003-04-15 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Specificity determinants of human cathepsin s revealed by crystal structures of complexes. Biochemistry, 42, 2003
1NPZ	Crystal structures of Cathepsin S inhibitor complexes Descriptor: Cathepsin S, N~2~-(morpholin-4-ylcarbonyl)-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-leucinamide Authors: Pauly, T.A, Sulea, T, Ammirati, M, Sivaraman, J, Danley, D.E, Griffor, M.C, Kamath, A.V, Wang, I.K, Laird, E.R, Seddon, A.P, Menard, R, Cygler, M, Rath, V.L. Deposit date: 2003-01-20 Release date: 2003-04-15 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Specificity determinants of human cathepsin s revealed by crystal structures of complexes. Biochemistry, 42, 2003
1NLJ	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT AZEPANONE INHIBITOR Descriptor: BENZOFURAN-2-CARBOXYLIC ACID {(S)-3-METHYL-1-[3-OXO-1-(PYRIDIN-2-YLSULFONYL)AZEPAN-4-YLCARBAMOYL]BUTYL}AMIDE, CATHEPSIN K Authors: Smith, W.W, Janson, C.A, Zhao, B. Deposit date: 2003-01-07 Release date: 2003-01-14 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Azepanone-Based Inhibitors of Human and Rat Cathepsin K J.Med.Chem., 44, 2001
1NL6	Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Azepanone Inhibitor Descriptor: 5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ACID ((S)-3-METHYL-1-{(S)-3-OXO-1-[2-(3-PYRIDIN-2-YLPHENYL)ACETYL]AZEPAN-4-YLCARBAMOYL}BUTYL)AMIDE, Cathepsin K Authors: Smith, W.W, Janson, C.A, Zhao, B. Deposit date: 2003-01-06 Release date: 2003-01-14 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Azepanone-based inhibitors of human and rat cathepsin K J.Med.Chem., 44, 2001

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