1Q6K

Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate

Summary for 1Q6K

Entry DOI	10.2210/pdb1q6k/pdb
Descriptor	Cathepsin K, SULFATE ION, TERT-BUTYL(1S)-1-CYCLOHEXYL-2-OXOETHYLCARBAMATE, ... (4 entities in total)
Functional Keywords	cathepsin k, catk, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P43235
Total number of polymer chains	1
Total formula weight	23860.87
Authors	Catalano, J.G.,Deaton, D.N.,Furfine, E.S.,Hassell, A.M.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Shewchuk, L.M.,Willard, D.H.,Wright, L.L. (deposition date: 2003-08-13, release date: 2004-03-16, Last modification date: 2023-08-16)
Primary citation	Catalano, J.G.,Deaton, D.N.,Furfine, E.S.,Hassell, A.M.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Shewchuk, L.M.,Willard, D.H.,Wright, L.L. Exploration of the P1 SAR of aldehyde cathepsin K inhibitors Bioorg.Med.Chem.Lett., 14:275-278, 2004 Cited by PubMed: 14684342 DOI: 10.1016/j.bmcl.2003.09.088 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation