1SNK

Cathepsin K complexed with carbamate derivatized norleucine aldehyde

Summary for 1SNK
DescriptorCathepsin K, SULFATE ION, N2-({[(4-BROMOPHENYL)METHYL]OXY}CARBONYL)-N1-[(1S)-1-FORMYLPENTYL]-L-LEUCINAMIDE, ... (4 entities in total)
Functional Keywordscatk, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationLysosome: P43235
Total number of polymer chains1
Total formula weight24181.95
Authors
Boros, E.E.,Deaton, D.N.,Hassell, A.M.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Shewchuk, L.M.,Thompson, J.B.,Willard Jr., D.H.,Wright, L.L. (deposition date: 2004-03-11, release date: 2004-06-22, Last modification date: 2017-10-11)
Primary citationBoros, E.E.,Deaton, D.N.,Hassell, A.M.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Paulick, M.G.,Shewchuk, L.M.,Thompson, J.B.,Willard Jr., D.H.,Wright, L.L.
Exploration of the P(2)-P(3) SAR of aldehyde cathepsin K inhibitors
Bioorg.Med.Chem.Lett., 14:3425-3429, 2004
PubMed: 15177446
DOI: 110.1016/j.bmcl.2004.04.084
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation
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PDB entries from 2021-06-16