1SNK

Cathepsin K complexed with carbamate derivatized norleucine aldehyde

Summary for 1SNK

Entry DOI	10.2210/pdb1snk/pdb
Descriptor	Cathepsin K, SULFATE ION, N2-({[(4-BROMOPHENYL)METHYL]OXY}CARBONYL)-N1-[(1S)-1-FORMYLPENTYL]-L-LEUCINAMIDE, ... (4 entities in total)
Functional Keywords	catk, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P43235
Total number of polymer chains	1
Total formula weight	24181.95
Authors	Boros, E.E.,Deaton, D.N.,Hassell, A.M.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Shewchuk, L.M.,Thompson, J.B.,Willard Jr., D.H.,Wright, L.L. (deposition date: 2004-03-11, release date: 2004-06-22, Last modification date: 2023-08-23)
Primary citation	Boros, E.E.,Deaton, D.N.,Hassell, A.M.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Paulick, M.G.,Shewchuk, L.M.,Thompson, J.B.,Willard Jr., D.H.,Wright, L.L. Exploration of the P(2)-P(3) SAR of aldehyde cathepsin K inhibitors Bioorg.Med.Chem.Lett., 14:3425-3429, 2004 Cited by PubMed: 15177446 DOI: 10.1016/j.bmcl.2004.04.084 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation