2UWN
 
 | | Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex with ligand. | | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, ACETATE ION, CHLORIDE ION, ... | | Authors: | Prosser, B.E, Johnson, S, Roversi, P, Herbert, A.P, Blaum, B.S, Tyrrell, J, Jowitt, T.A, Clark, S.J, Terelli, E, Uhrin, D, Barlow, P.N, Sim, R.B, Day, A.J, Lea, S.M. | | Deposit date: | 2007-03-22 | | Release date: | 2007-10-02 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration.
J.Exp.Med., 204, 2007
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2EHF
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2JGX
 | | Structure of CCP module 7 of complement factor H - The AMD Not at risk varient (402Y) | | Descriptor: | COMPLEMENT FACTOR H | | Authors: | Herbert, A.P, Deakin, J.A, Schmidt, C.Q, Blaum, B.S, Egan, C, Ferreira, V.P, Pangburn, M.K, Lyon, M, Uhrin, D, Barlow, P.N. | | Deposit date: | 2007-02-16 | | Release date: | 2007-03-20 | | Last modified: | 2018-05-02 | | Method: | SOLUTION NMR | | Cite: | Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.
J. Biol. Chem., 282, 2007
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2JGW
 | | Structure of CCP module 7 of complement factor H - The AMD at risk varient (402H) | | Descriptor: | COMPLEMENT FACTOR H | | Authors: | Herbert, A.P, Deakin, J.A, Schmidt, C.Q, Blaum, B.S, Egan, C, Ferreira, V.P, Pangburn, M.K, Lyon, M, Uhrin, D, Barlow, P.N. | | Deposit date: | 2007-02-16 | | Release date: | 2007-03-20 | | Last modified: | 2018-05-02 | | Method: | SOLUTION NMR | | Cite: | Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.
J. Biol. Chem., 282, 2007
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2OK5
 | | Human Complement factor B | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement factor B, ... | | Authors: | Milder, F.J, Gomes, L, Schouten, A, Janssen, B.J.C, Huizinga, E.G, Romijn, R.A, Hemrika, W, Roos, A, Daha, M.R, Gros, P. | | Deposit date: | 2007-01-16 | | Release date: | 2007-02-27 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Factor B structure provides insights into activation of the central protease of the complement system.
Nat.Struct.Mol.Biol., 14, 2007
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2O39
 | | Human Adenovirus type 11 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP) | | Descriptor: | CALCIUM ION, Fiber protein, Membrane cofactor protein, ... | | Authors: | Persson, D.B, Reiter, D.M, Arnberg, N, Stehle, T. | | Deposit date: | 2006-12-01 | | Release date: | 2007-01-09 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Adenovirus type 11 binding alters the conformation of its receptor CD46.
Nat.Struct.Mol.Biol., 14, 2007
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2IC4
 | | Solution structure of the His402 allotype of the Factor H SCR6-SCR7-SCR8 fragment | | Descriptor: | Complement factor H | | Authors: | Fernando, A.N, Furtado, P.B, Gilbert, H.E, Clark, S.J, Day, A.J, Sim, R.B, Perkins, S.J. | | Deposit date: | 2006-09-12 | | Release date: | 2007-04-10 | | Last modified: | 2024-02-21 | | Method: | SOLUTION SCATTERING | | Cite: | Associative and Structural Properties of the Region of Complement Factor H Encompassing the Tyr402His Disease-related Polymorphism and its Interactions with Heparin.
J.Mol.Biol., 368, 2007
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2GSX
 | | Complement Receptor Type 2 | | Descriptor: | Complement receptor type 2 | | Authors: | Gilbert, H.E, Asokan, R, Holers, V.M, Perkins, S.J. | | Deposit date: | 2006-04-27 | | Release date: | 2006-09-26 | | Last modified: | 2024-02-14 | | Method: | SOLUTION SCATTERING | | Cite: | The 15 SCR Flexible Extracellular Domains of Human Complement Receptor Type 2 can Mediate Multiple Ligand and Antigen Interactions.
J.Mol.Biol., 362, 2006
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2G7I
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2C8I
 | | Complex Of Echovirus Type 12 With Domains 1, 2, 3 and 4 Of Its Receptor Decay Accelerating Factor (Cd55) By Cryo Electron Microscopy At 16 A | | Descriptor: | COMPLEMENT DECAY-ACCELERATING FACTOR, ECHOVIRUS 11 COAT PROTEIN VP1, ECHOVIRUS 11 COAT PROTEIN VP2, ... | | Authors: | Pettigrew, D.M, Williams, D.T, Kerrigan, D, Evans, D.J, Lea, S.M, Bhella, D. | | Deposit date: | 2005-12-05 | | Release date: | 2006-01-17 | | Last modified: | 2017-08-30 | | Method: | ELECTRON MICROSCOPY (14 Å) | | Cite: | Structural and Functional Insights Into the Interaction of Echoviruses and Decay-Accelerating Factor.
J.Biol.Chem., 281, 2006
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2ERJ
 | | Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Debler, E.W, Stauber, D.J, Wilson, I.A. | | Deposit date: | 2005-10-25 | | Release date: | 2006-02-21 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2B5I
 | | cytokine receptor complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common gamma chain, ... | | Authors: | Wang, X, Rickert, M, Garcia, K.C. | | Deposit date: | 2005-09-28 | | Release date: | 2005-11-29 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.
Science, 310, 2005
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2ATY
 | | Complement receptor chimaeric conjugate CR2-Ig | | Descriptor: | Complement receptor chimeric conjugate CR2-Ig | | Authors: | Gilbert, H.E, Aslam, M, Guthridge, J.M, Holers, V.M, Perkins, S.J. | | Deposit date: | 2005-08-26 | | Release date: | 2006-01-31 | | Last modified: | 2024-02-14 | | Method: | SOLUTION SCATTERING | | Cite: | Extended Flexible Linker Structures in the Complement Chimaeric Conjugate CR2-Ig by Scattering, Analytical Ultracentrifugation and Constrained Modelling: Implications for Function and Therapy.
J.Mol.Biol., 356, 2006
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2BZM
 | | Solution structure of the primary host recognition region of complement factor H | | Descriptor: | COMPLEMENT FACTOR H | | Authors: | Herbert, A.P, Uhrin, D, Lyon, M, Pangburn, M.K, Barlow, P.N. | | Deposit date: | 2005-08-18 | | Release date: | 2006-03-22 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Disease-Associated Sequence Variations Congregate in a Polyanion Recognition Patch on Human Factor H Revealed in Three-Dimensional Structure.
J.Biol.Chem., 281, 2006
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2A55
 | | Solution structure of the two N-terminal CCP modules of C4b-binding protein (C4BP) alpha-chain. | | Descriptor: | C4b-binding protein | | Authors: | Jenkins, H.T, Mark, L, Ball, G, Lindahl, G, Uhrin, D, Blom, A.M, Barlow, P.N. | | Deposit date: | 2005-06-30 | | Release date: | 2005-12-13 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | Human C4b-binding Protein, Structural Basis for Interaction with Streptococcal M Protein, a Major Bacterial Virulence Factor
J.Biol.Chem., 281, 2006
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1ZJK
 | | Crystal structure of the zymogen catalytic region of human MASP-2 | | Descriptor: | Mannan-binding lectin serine protease 2 | | Authors: | Gal, P, Harmat, V, Kocsis, A, Bian, T, Barna, L, Ambrus, G, Vegh, B, Balczer, J, Sim, R.B, Naray-Szabo, G, Zavodszky, P. | | Deposit date: | 2005-04-29 | | Release date: | 2005-07-26 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | A True Autoactivating Enzyme: Structural insight into mannose-binding lectin-associated serine protease-2 activations
J.Biol.Chem., 280, 2005
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1Z92
 | | structure of interleukin-2 with its alpha receptor | | Descriptor: | Interleukin-2, Interleukin-2 receptor alpha chain | | Authors: | Rickert, M, Wang, X.Q, Goriatcheva, N, Boulanger, M.J, Garcia, K.C. | | Deposit date: | 2005-03-31 | | Release date: | 2005-06-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The structure of interleukin-2 complexed with its alpha receptor.
Science, 308, 2005
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1W2R
 | | Solution structure of CR2 SCR 1-2 by X-ray scattering | | Descriptor: | COMPLEMENT RECEPTOR TYPE 2 PRECURSOR, | | Authors: | Gilbert, H.E, Hannan, J.P, Holers, V.M, Perkins, S.J. | | Deposit date: | 2004-07-08 | | Release date: | 2005-09-29 | | Method: | SOLUTION SCATTERING | | Cite: | Solution Structure of the Complex between Cr2 Scr 1-2 and C3D of Human Complement: An X-Ray Scattering and Sedimentation Modelling Study.
J.Mol.Biol., 346, 2005
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1W2S
 | | Solution structure of CR2 SCR 1-2 in its complex with C3d by X-ray scattering | | Descriptor: | COMPLEMENT C3 PRECURSOR, COMPLEMENT RECEPTOR TYPE 2 PRECURSOR, | | Authors: | Gilbert, H.E, Hannan, J.P, Holers, V.M, Perkins, S.J. | | Deposit date: | 2004-07-08 | | Release date: | 2005-09-29 | | Method: | SOLUTION SCATTERING | | Cite: | Solution Structure of the Complex between Cr2 Scr 1-2 and C3D of Human Complement: An X-Ray Scattering and Sedimentation Modelling Study.
J.Mol.Biol., 346, 2005
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1SS2
 | | Solution structure of the second complement control protein (CCP) module of the GABA(B)R1a receptor, Pro-119 cis conformer | | Descriptor: | Gamma-aminobutyric acid type B receptor, subunit 1 | | Authors: | Blein, S, Uhrin, D, Smith, B.O, White, J.H, Barlow, P.N. | | Deposit date: | 2004-03-23 | | Release date: | 2004-10-12 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded.
J.Biol.Chem., 279, 2004
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1SRZ
 | | Solution structure of the second complement control protein (CCP) module of the GABA(B)R1a receptor, Pro-119 trans conformer | | Descriptor: | Gamma-aminobutyric acid type B receptor, subunit 1 | | Authors: | Blein, S, Uhrin, D, Smith, B.O, White, J.H, Barlow, P.N. | | Deposit date: | 2004-03-23 | | Release date: | 2004-10-12 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Structural Analysis of the Complement Control Protein (CCP) Modules of GABAB Receptor 1a: ONLY ONE OF THE TWO CCP MODULES IS COMPACTLY FOLDED
J.Biol.Chem., 279, 2004
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1UPN
 | | COMPLEX OF ECHOVIRUS TYPE 12 WITH DOMAINS 3 AND 4 OF ITS RECEPTOR DECAY ACCELERATING FACTOR (CD55) BY CRYO ELECTRON MICROSCOPY AT 16 A | | Descriptor: | COMPLEMENT DECAY-ACCELERATING FACTOR, ECHOVIRUS 11 COAT PROTEIN VP1, ECHOVIRUS 11 COAT PROTEIN VP2, ... | | Authors: | Bhella, D, Goodfellow, I.G, Roversi, P, Pettigrew, D, Chaudry, Y, Evans, D.J, Lea, S.M. | | Deposit date: | 2003-10-08 | | Release date: | 2004-01-07 | | Last modified: | 2017-08-30 | | Method: | ELECTRON MICROSCOPY (16 Å) | | Cite: | The Structure of Echovirus Type 12 Bound to a Two-Domain Fragment of its Cellular Attachment Protein Decay-Accelerating Factor (Cd 55)
J.Biol.Chem., 279, 2004
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1UOT
 | | HUMAN CD55 DOMAINS 3 & 4 | | Descriptor: | COMPLEMENT DECAY-ACCELERATING FACTOR | | Authors: | Williams, P, Chaudhry, Y, Goodfellow, I.G, Billington, J, Spiller, B, Evans, D.J, Lea, S.M. | | Deposit date: | 2003-09-23 | | Release date: | 2003-09-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Mapping Cd55 Function. The Structure of Two Pathogen-Binding Domains at 1.7 A
J.Biol.Chem., 278, 2003
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1Q3X
 | | Crystal structure of the catalytic region of human MASP-2 | | Descriptor: | GLYCEROL, Mannan-binding lectin serine protease 2, SODIUM ION | | Authors: | Harmat, V, Gal, P, Kardos, J, Szilagyi, K, Ambrus, G, Naray-Szabo, G, Zavodszky, P. | | Deposit date: | 2003-08-01 | | Release date: | 2004-08-03 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.23 Å) | | Cite: | The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions
J.Mol.Biol., 342, 2004
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1OK9
 | | Decay accelerating factor (CD55): The structure of an intact human complement regulator. | | Descriptor: | ACETATE ION, CHLORIDE ION, COMPLEMENT DECAY-ACCELERATING FACTOR, ... | | Authors: | Lukacik, P, Roversi, P, White, J, Esser, D, Smith, G.P, Billington, J, Williams, P.A, Rudd, P.M, Wormald, M.R, Crispin, M.D.M, Radcliffe, C.M, Dwek, R.A, Evans, D.J, Morgan, B.P, Smith, R.A.G, Lea, S.M. | | Deposit date: | 2003-07-21 | | Release date: | 2004-01-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Complement Regulation at the Molecular Level: The Structure of Decay-Accelerating Factor
Proc.Natl.Acad.Sci.USA, 101, 2004
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