4ZOW
| Crystal structure of E. coli multidrug transporter MdfA in complex with chloramphenicol | Descriptor: | CHLORAMPHENICOL, Multidrug transporter MdfA | Authors: | Zhang, X.C, Heng, J, Zhao, Y, Wang, X. | Deposit date: | 2015-05-07 | Release date: | 2015-08-19 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Substrate-bound structure of the E. coli multidrug resistance transporter MdfA Cell Res., 25, 2015
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4ZP2
| Crystal structure of E. coli multidrug transporter MdfA in complex with n-dodecyl-N,N-dimethylamine-N-oxide | Descriptor: | LAURYL DIMETHYLAMINE-N-OXIDE, Multidrug transporter MdfA | Authors: | Zhang, X.C, Heng, J, Zhao, Y, Wang, X. | Deposit date: | 2015-05-07 | Release date: | 2015-08-19 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Substrate-bound structure of the E. coli multidrug resistance transporter MdfA Cell Res., 25, 2015
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4ZWB
| Crystal structure of maltose-bound human GLUT3 in the outward-occluded conformation at 2.4 angstrom | Descriptor: | Solute carrier family 2, facilitated glucose transporter member 3, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Deng, D, Sun, P.C, Yan, C.Y, Yan, N. | Deposit date: | 2015-05-19 | Release date: | 2015-07-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Molecular basis of ligand recognition and transport by glucose transporters Nature, 526, 2015
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4ZWC
| Crystal structure of maltose-bound human GLUT3 in the outward-open conformation at 2.6 angstrom | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Solute carrier family 2, facilitated glucose transporter member 3, ... | Authors: | Deng, D, Sun, P.C, Yan, C.Y, Yan, N. | Deposit date: | 2015-05-19 | Release date: | 2015-07-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Molecular basis of ligand recognition and transport by glucose transporters Nature, 526, 2015
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4ZW9
| Crystal structure of human GLUT3 bound to D-glucose in the outward-occluded conformation at 1.5 angstrom | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Solute carrier family 2, facilitated glucose transporter member 3, ... | Authors: | Deng, D, Sun, P.C, Yan, C.Y, Yan, N. | Deposit date: | 2015-05-19 | Release date: | 2015-07-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.502 Å) | Cite: | Molecular basis of ligand recognition and transport by glucose transporters Nature, 526, 2015
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8ET8
| Cryo-EM structure of the organic cation transporter 1 in complex with verapamil | Descriptor: | (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, OCT1 | Authors: | Suo, Y, Wright, N.J, Lee, S.-Y. | Deposit date: | 2022-10-16 | Release date: | 2023-05-31 | Last modified: | 2023-08-02 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2. Nat.Struct.Mol.Biol., 30, 2023
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8EX7
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8ET9
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8ET7
| Cryo-EM structure of the organic cation transporter 1 in complex with diphenhydramine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE, OCT1 | Authors: | Suo, Y, Wright, N.J, Lee, S.-Y. | Deposit date: | 2022-10-16 | Release date: | 2023-05-31 | Last modified: | 2023-08-02 | Method: | ELECTRON MICROSCOPY (3.77 Å) | Cite: | Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2. Nat.Struct.Mol.Biol., 30, 2023
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8EX4
| Human S1P transporter Spns2 in an inward-facing open conformation (state 1) | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Sphingosine-1-phosphate transporter SPNS2 | Authors: | Ahmed, S, Zhao, H, Dai, Y, Lee, C.H. | Deposit date: | 2022-10-24 | Release date: | 2023-05-31 | Last modified: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate. Cell, 186, 2023
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8EX5
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8ET6
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8EX6
| Human S1P transporter Spns2 in an inward-facing open conformation (state 1*) | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Sphingosine-1-phosphate transporter SPNS2 | Authors: | Ahmed, S, Zhao, H, Dai, Y, Lee, C.H. | Deposit date: | 2022-10-24 | Release date: | 2023-05-31 | Last modified: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate. Cell, 186, 2023
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8EX8
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7ZH0
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7ZH6
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7ZHA
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7YUF
| apo human SPNS2 | Descriptor: | NbFab H-chain, NbFab L-chain, Sphingosine-1-phosphate transporter SPNS2, ... | Authors: | He, Y, Duan, Y. | Deposit date: | 2022-08-17 | Release date: | 2023-09-06 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Res., 34, 2024
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7YUD
| FTY720p-bound human SPNS2 | Descriptor: | (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, NbFab L-chain, NbFab-H-chain, ... | Authors: | He, Y, Duan, Y. | Deposit date: | 2022-08-17 | Release date: | 2023-09-06 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Res., 34, 2024
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7YUB
| S1P-bound human SPNS2 | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, NbFab-H-chain, NbFab-L-chain, ... | Authors: | He, Y, Duan, Y. | Deposit date: | 2022-08-17 | Release date: | 2023-09-06 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Res., 34, 2024
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8BVS
| Cryo-EM structure of rat SLC22A6 bound to tenofovir | Descriptor: | CHLORIDE ION, Solute carrier family 22 member 6, Synthetic nanobody (Sybody), ... | Authors: | Parker, J.L, Kato, T, Newstead, S. | Deposit date: | 2022-12-05 | Release date: | 2023-07-19 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1. Nat.Struct.Mol.Biol., 30, 2023
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8BVT
| Cryo-EM structure of rat SLC22A6 bound to probenecid | Descriptor: | 4-(dipropylsulfamoyl)benzoic acid, Solute carrier family 22 member 6, Synthetic nanobody (Sybody) | Authors: | Parker, J.L, Kato, T, Newstead, S. | Deposit date: | 2022-12-06 | Release date: | 2023-07-19 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.94 Å) | Cite: | Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1. Nat.Struct.Mol.Biol., 30, 2023
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8BW7
| Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid | Descriptor: | 2-OXOGLUTARIC ACID, CHLORIDE ION, Solute carrier family 22 member 6, ... | Authors: | Parker, J.L, Kato, T, Newstead, S. | Deposit date: | 2022-12-06 | Release date: | 2023-07-19 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1. Nat.Struct.Mol.Biol., 30, 2023
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8BVR
| Cryo-EM structure of rat SLC22A6 in the apo state | Descriptor: | PHOSPHATE ION, Solute carrier family 22 member 6, Synthetic nanobody (Sybody) | Authors: | Parker, J.L, Kato, T, Newstead, S. | Deposit date: | 2022-12-05 | Release date: | 2023-07-19 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1. Nat.Struct.Mol.Biol., 30, 2023
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8JTA
| Human VMAT2 complex with tetrabenazine | Descriptor: | Synaptic vesicular amine transporter, tetrabenazine | Authors: | Jiang, D.H, Wu, D. | Deposit date: | 2023-06-21 | Release date: | 2023-11-29 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | Transport and inhibition mechanisms of human VMAT2. Nature, 626, 2024
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