6QW6
 
 | | Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution. | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Charenton, C, Wilkinson, M.E, Nagai, K. | | 登録日 | 2019-03-05 | | 公開日 | 2019-04-17 | | 最終更新日 | 2020-10-07 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | Mechanism of 5' splice site transfer for human spliceosome activation.
Science, 364, 2019
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6NX5
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6NWW
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6NTY
 | | 2.1 A resolution structure of the Musashi-2 (Msi2) RNA recognition motif 1 (RRM1) domain | | 分子名称: | PHOSPHATE ION, RNA-binding protein Musashi homolog 2 | | 著者 | Lovell, S, Kashipathy, M.M, Battaile, K.P, Lan, L, Xiaoqing, W, Cooper, A, Gao, F.P, Xu, L. | | 登録日 | 2019-01-30 | | 公開日 | 2019-10-23 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal and solution structures of human oncoprotein Musashi-2 N-terminal RNA recognition motif 1.
Proteins, 88, 2020
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6NSX
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6J6G
 | | Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom | | 分子名称: | ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | | 登録日 | 2019-01-15 | | 公開日 | 2019-04-24 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell, 177, 2019
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6J6H
 | | Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom | | 分子名称: | ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | | 登録日 | 2019-01-15 | | 公開日 | 2019-04-24 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell, 177, 2019
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6J6N
 | | Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | | 登録日 | 2019-01-15 | | 公開日 | 2019-04-24 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | | 主引用文献 | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell, 177, 2019
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6J6Q
 | | Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | | 登録日 | 2019-01-15 | | 公開日 | 2019-04-24 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell, 177, 2019
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6QDV
 | | Human post-catalytic P complex spliceosome | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | | 著者 | Fica, S.M, Oubridge, C, Wilkinson, M.E, Newman, A.J, Nagai, K. | | 登録日 | 2019-01-03 | | 公開日 | 2019-02-20 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.
Science, 363, 2019
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6NCQ
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6N7X
 | | S. cerevisiae U1 snRNP | | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, Pre-mRNA-processing factor 39, Protein NAM8, ... | | 著者 | Li, X, Liu, S, Jiang, J, Zhang, L, Espinosa, S, Hill, R.C, Hansen, K.C, Zhou, Z.H, Zhao, R. | | 登録日 | 2018-11-28 | | 公開日 | 2019-07-24 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing.
Nat Commun, 8, 2017
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6N7R
 | | Saccharomyces cerevisiae spliceosomal E complex (ACT1) | | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA, Pre-mRNA-processing factor 39, ... | | 著者 | Liu, S, Li, X, Zhou, Z.H, Zhao, R. | | 登録日 | 2018-11-28 | | 公開日 | 2019-09-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | A unified mechanism for intron and exon definition and back-splicing.
Nature, 573, 2019
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6N7P
 | | S. cerevisiae spliceosomal E complex (UBC4) | | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, Nuclear cap-binding protein complex subunit 1, Nuclear cap-binding protein subunit 2, ... | | 著者 | Liu, S, Li, X, Zhou, Z.H, Zhao, R. | | 登録日 | 2018-11-27 | | 公開日 | 2019-09-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | A unified mechanism for intron and exon definition and back-splicing.
Nature, 573, 2019
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6N3D
 | | Structure of HIV Tat-specific factor 1 U2AF Homology Motif (APO-State) | | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Loerch, S, Jenkins, J.L, Kielkopf, C.L. | | 登録日 | 2018-11-15 | | 公開日 | 2019-01-02 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
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6N3F
 | | Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to SF3b1 ULM5 | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, HIV Tat-specific factor 1, ... | | 著者 | Leach, J.R, Jenkins, J.L, Kielkopf, C.L. | | 登録日 | 2018-11-15 | | 公開日 | 2019-01-02 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | | 主引用文献 | The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
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6N3E
 | | Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to U2AF ligand motif 4 | | 分子名称: | FORMIC ACID, GLYCEROL, HIV Tat-specific factor 1, ... | | 著者 | Loerch, S, Jenkins, J.L, Kielkopf, C.L. | | 登録日 | 2018-11-15 | | 公開日 | 2019-01-02 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.893 Å) | | 主引用文献 | The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
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6HPJ
 | | Structure of human SRSF1 RRM1 bound to AACAAA RNA | | 分子名称: | Immunoglobulin G-binding protein G,Serine/arginine-rich splicing factor 1, RNA (5'-R(*AP*AP*CP*AP*AP*A)-3') | | 著者 | Allain, F.T.H, Clery, A. | | 登録日 | 2018-09-21 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing.
Nat Commun, 12, 2021
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6ICZ
 | | Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | | 著者 | Zhang, X, Zhan, X, Yan, C, Shi, Y. | | 登録日 | 2018-09-07 | | 公開日 | 2019-03-13 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structures of the human spliceosomes before and after release of the ligated exon.
Cell Res., 29, 2019
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6ID0
 | | Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | | 著者 | Zhang, X, Zhan, X, Yan, C, Shi, Y. | | 登録日 | 2018-09-07 | | 公開日 | 2019-03-13 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structures of the human spliceosomes before and after release of the ligated exon.
Cell Res., 29, 2019
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6ID1
 | | Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolution | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | | 著者 | Zhang, X, Zhan, X, Yan, C, Shi, Y. | | 登録日 | 2018-09-07 | | 公開日 | 2019-03-13 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Structures of the human spliceosomes before and after release of the ligated exon.
Cell Res., 29, 2019
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6HIP
 | | Structure of SPF45 UHM bound to HIV-1 Rev ULM | | 分子名称: | HIV-1 Rev (41-49), SODIUM ION, Splicing factor 45, ... | | 著者 | Pabis, M, Corsini, L, Sattler, M. | | 登録日 | 2018-08-30 | | 公開日 | 2019-03-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Modulation of HIV-1 gene expression by binding of a ULM motif in the Rev protein to UHM-containing splicing factors.
Nucleic Acids Res., 47, 2019
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6AHD
 | | The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, Brr2, U5 small nuclear ribonucleoprotein 200 kDa helicase, ... | | 著者 | Zhan, X, Yan, C, Zhang, X, Shi, Y. | | 登録日 | 2018-08-17 | | 公開日 | 2018-11-14 | | 最終更新日 | 2021-06-30 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structures of the human pre-catalytic spliceosome and its precursor spliceosome.
Cell Res., 28, 2018
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6AH0
 | | The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Zhan, X, Yan, C, Zhang, X, Shi, Y. | | 登録日 | 2018-08-15 | | 公開日 | 2018-11-14 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | | 主引用文献 | Structures of the human pre-catalytic spliceosome and its precursor spliceosome.
Cell Res., 28, 2018
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6E4N
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