6HPJ

Structure of human SRSF1 RRM1 bound to AACAAA RNA

Summary for 6HPJ

• Entry DOI: 10.2210/pdb6hpj/pdb
• NMR Information: BMRB: 34317
• Descriptor: Immunoglobulin G-binding protein G,Serine/arginine-rich splicing factor 1, RNA (5'-R(*AP*AP*CP*AP*AP*A)-3') (2 entities in total)
• Functional Keywords: splicing, sr protein, srsf1, rrm, spinal muscular atrophy, sma, rna, rna binding protein
• Biological source: Streptococcus sp. group G; More
• Total number of polymer chains: 2
• Total formula weight: 19862.95

Authors

Allain, F.T.H.,Clery, A. (deposition date: 2018-09-21, release date: 2020-11-18, Last modification date: 2021-06-02)

• Primary citation: Clery, A.,Krepl, M.,Nguyen, C.K.X.,Moursy, A.,Jorjani, H.,Katsantoni, M.,Okoniewski, M.,Mittal, N.,Zavolan, M.,Sponer, J.,Allain, F.H.; Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing.; Nat Commun, 12:428-428, 2021; PubMed: 33462199; DOI: 10.1038/s41467-020-20481-w

Experimental method

SOLUTION NMR