PDB: 123 件ウェブページステータス検索Chemie searchBIRD

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6PX5	CRYSTAL STRUCTURE OF HUMAN MEIZOTHROMBIN DESF1 MUTANT S195A bound with PPACK 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Prothrombin, ... 著者 Pelc, L.A, Koester, S.K, Chen, Z, Gistover, N, Di Cera, E. 登録日 2019-07-24 公開日 2019-09-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin. Sci Rep, 9, 2019
6OG4	plasminogen binding group A streptococcal M protein 分子名称: Plasminogen, Plasminogen-binding group A streptococcal M-like protein PAM, SULFATE ION 著者 Law, R.H.P, Quek, A.J, Whisstock, J.C, Caradoc-Davies, T.T. 登録日 2019-04-01 公開日 2019-07-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding. J.Mol.Biol., 431, 2019
6OQJ	SOLUTION STRUCTURE OF THE COMPLEX OF MUTANT VEK50[RH1/AA] AND PLASMINOGEN KRINGLE 2 分子名称: Plasminogen kringle 2, Plasminogen-binding group A streptococcal M-like protein PAM 著者 Yuan, Y, Castellino, F.J. 登録日 2019-04-26 公開日 2019-07-24 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes. J.Struct.Biol., 208, 2019
6OQK	SOLUTION STRUCTURE OF THE COMPLEX OF MUTANT VEK50[RH2/AA] AND PLASMINOGEN KRINGLE 2 分子名称: Plasminogen Kringle 2, Plasminogen-binding group A streptococcal M-like protein PAM 著者 Yuan, Y, Castellino, F.J. 登録日 2019-04-26 公開日 2019-07-24 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes. J.Struct.Biol., 208, 2019
6BJR	Crystal structure of prothrombin mutant S101C/A470C 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Prothrombin, ... 著者 Chinnaraj, M, Chen, Z, Pelc, L, Grese, Z, Bystranowska, D, Di Cera, E, Pozzi, N. 登録日 2017-11-06 公開日 2018-06-27 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (6 Å) 主引用文献 Structure of prothrombin in the closed form reveals new details on the mechanism of activation. Sci Rep, 8, 2018
6BA5	Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1 分子名称: Inactive tyrosine-protein kinase transmembrane receptor ROR1, Variable domain Heavy chain, antibody R11, ... 著者 Park, H, Rader, C. 登録日 2017-10-12 公開日 2018-06-13 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BAN	Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1 分子名称: Inactive tyrosine-protein kinase transmembrane receptor ROR1, Variable domain R11 Heavy chain, Variable domain of R11 Light Chain 著者 Park, H, Rader, C. 登録日 2017-10-14 公開日 2018-06-13 最終更新日 2019-12-04 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5Z55	NMR Solution Structure of the Kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1) 分子名称: Inactive tyrosine-protein kinase transmembrane receptor ROR1 著者 Ma, X, Hu, K.F. 登録日 2018-01-17 公開日 2018-05-16 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Backbone and side-chain chemical shift assignments of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1). Biomol NMR Assign, 12, 2018
6C2W	Crystal structure of human prothrombin mutant S101C/A470C 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Prothrombin, ... 著者 Chinnaraj, M, Chen, Z, Pelc, L, Grese, Z, Bystranowska, D, Di Cera, E, Pozzi, N. 登録日 2018-01-09 公開日 2018-02-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (4.12 Å) 主引用文献 Structure of prothrombin in the closed form reveals new details on the mechanism of activation. Sci Rep, 8, 2018
5FWV	Wnt modulator Kremen crystal form III at 3.2A 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, KREMEN PROTEIN 1 著者 Zebisch, M, Jackson, V.A, Jones, E.Y. 登録日 2016-02-21 公開日 2016-07-20 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight Into Ternary Complex Formation with Lrp6 and Dickkopf Structure, 24, 2016
5FWS	Wnt modulator Kremen crystal form I at 1.90A 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, KREMEN PROTEIN 1, ... 著者 Zebisch, M, Jackson, V.A, Jones, E.Y. 登録日 2016-02-21 公開日 2016-07-20 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight Into Ternary Complex Formation with Lrp6 and Dickkopf Structure, 24, 2016
5FWW	Wnt modulator Kremen in complex with DKK1 (CRD2) and LRP6 (PE3PE4) 分子名称: CALCIUM ION, DICKKOPF-RELATED PROTEIN 1, KREMEN PROTEIN 1, ... 著者 Zebisch, M, Jackson, V.A, Jones, E.Y. 登録日 2016-02-21 公開日 2016-07-20 最終更新日 2016-09-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight Into Ternary Complex Formation with Lrp6 and Dickkopf Structure, 24, 2016
5FWT	Wnt modulator Kremen crystal form I at 2.10A 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, KREMEN PROTEIN 1, ... 著者 Zebisch, M, Jackson, V.A, Jones, E.Y. 登録日 2016-02-21 公開日 2016-07-20 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight Into Ternary Complex Formation with Lrp6 and Dickkopf Structure, 24, 2016
5FWU	Wnt modulator Kremen crystal form II at 2.8A 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, KREMEN PROTEIN 1 著者 Zebisch, M, Jackson, V.A, Jones, E.Y. 登録日 2016-02-21 公開日 2016-07-20 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight Into Ternary Complex Formation with Lrp6 and Dickkopf Structure, 24, 2016
5EDM	Crystal structure of prothrombin deletion mutant residues 154-167 ( Form I ) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... 著者 Pozzi, N, Chen, Z, Di Cera, E. 登録日 2015-10-21 公開日 2016-01-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin. J.Biol.Chem., 291, 2016
5EDK	Crystal structure of prothrombin deletion mutant residues 146-167 ( Form II ). 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... 著者 Pozzi, N, Chen, Z, Di Cera, E. 登録日 2015-10-21 公開日 2016-01-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.214 Å) 主引用文献 How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin. J.Biol.Chem., 291, 2016
4D3C	Crystal structure of the NK1 domain of HGF in complex with anti-HGF monoclonal antibody SFN68. 分子名称: HEPATOCYTE GROWTH FACTOR, SFN68 FAB 著者 Kang, Y.J, Kim, K.L, Cho, H.S, Chung, J.H. 登録日 2014-10-21 公開日 2016-01-13 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist. to be published
5CP9	The structure of the NK1 fragment of HGF/SF complexed with MB605 分子名称: 1,2-ETHANEDIOL, 3-(furan-2-yl)propanoic acid, Hepatocyte growth factor 著者 Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. 登録日 2015-07-21 公開日 2015-08-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6, 2015
5COE	The structure of the NK1 fragment of HGF/SF complexed with HEPES 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Hepatocyte growth factor 著者 Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Ascher, D.B, Chirgadze, D.Y, Blundell, T.L, Gherardi, E. 登録日 2015-07-20 公開日 2015-08-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6, 2015
5CSQ	The structure of the NK1 fragment of HGF/SF complexed with MOPS 分子名称: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Hepatocyte growth factor 著者 Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. 登録日 2015-07-23 公開日 2015-08-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6, 2015
5CS9	The structure of the NK1 fragment of HGF/SF complexed with MES 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Hepatocyte growth factor 著者 Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. 登録日 2015-07-23 公開日 2015-08-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6, 2015
5CT1	The structure of the NK1 fragment of HGF/SF complexed with CHES 分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Hepatocyte growth factor 著者 Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. 登録日 2015-07-23 公開日 2015-08-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6, 2015
5CS1	The structure of the NK1 fragment of HGF/SF 分子名称: Hepatocyte growth factor 著者 Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. 登録日 2015-07-23 公開日 2015-08-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6, 2015
5CS5	The structure of the NK1 fragment of HGF/SF complexed with PIPES 分子名称: Hepatocyte growth factor, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID) 著者 Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. 登録日 2015-07-23 公開日 2015-08-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6, 2015
5CT2	The structure of the NK1 fragment of HGF/SF complexed with CAPS 分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Hepatocyte growth factor 著者 Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. 登録日 2015-07-23 公開日 2015-08-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6, 2015

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