7FCV
 
 | | Cryo-EM structure of the Potassium channel AKT1 mutant from Arabidopsis thaliana | | 分子名称: | PHOSPHATIDYLETHANOLAMINE, POTASSIUM ION, Potassium channel AKT1 | | 著者 | Yang, G.H, Lu, Y.M, Jia, Y.T, Zhang, Y.M, Tang, R.F, Xu, X, Li, X.M, Lei, J.L. | | 登録日 | 2021-07-15 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-04-12 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis.
Nat Commun, 13, 2022
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3OD0
 | | Crystal structure of cGMP bound cGMP-dependent protein kinase(92-227) | | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, PRKG1 protein | | 著者 | Kim, J.J, Huang, G, Kwon, T.K, Zwart, P, Headd, J, Kim, C. | | 登録日 | 2010-08-10 | | 公開日 | 2011-05-11 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Co-Crystal Structures of PKG Ibeta (92-227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding
Plos One, 6, 2011
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3U0Z
 | | Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | | 著者 | Lolicato, M, Nardini, M, Gazzarrini, S, Moller, S, Bertinetti, D, Herberg, F.W, Bolognesi, M, Martin, H, Fasolini, M, Bertrand, J.A, Arrigoni, C, Thiel, G, Moroni, A. | | 登録日 | 2011-09-29 | | 公開日 | 2011-10-26 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
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2H6C
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3CO2
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7RHS
 | | Cryo-EM structure of apo-state of human CNGA3/CNGB3 channel | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cyclic nucleotide-gated cation channel alpha-3, Cyclic nucleotide-gated cation channel beta-3, ... | | 著者 | Zheng, X, Yang, J. | | 登録日 | 2021-07-18 | | 公開日 | 2022-03-02 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | Structure of the human cone photoreceptor cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 29, 2022
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3RDI
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4JV4
 | | Crystal Structure of RIalpha(91-379) bound to HE33, a N6 di-propyl substituted cAMP analog | | 分子名称: | (2R,4aR,6R,7R,7aS)-6-[6-(dipropylamino)-9H-purin-9-yl]tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide, cAMP-dependent protein kinase type I-alpha regulatory subunit | | 著者 | Brown, S.H.J, Cheng, C.Y, Saldanha, A.S, Wu, J, Cottam, H, Sankaran, B, Taylor, S.S. | | 登録日 | 2013-03-25 | | 公開日 | 2013-09-18 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.952 Å) | | 主引用文献 | Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs.
Acs Chem.Biol., 8, 2013
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3N4M
 | | E. coli RNA polymerase alpha subunit C-terminal domain in complex with CAP and DNA | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Lara-Gonzalez, S, Birktoft, J.J, Lawson, C.L. | | 登録日 | 2010-05-21 | | 公開日 | 2011-05-25 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.987 Å) | | 主引用文献 | The RNA Polymerase alpha Subunit Recognizes the DNA Shape of the Upstream Promoter Element.
Biochemistry, 59, 2020
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7RSH
 | | SthK Y26F Closed State | | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | | 著者 | Gao, X, Nimigean, C. | | 登録日 | 2021-08-11 | | 公開日 | 2022-11-23 | | 最終更新日 | 2022-11-30 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel.
Nat Commun, 13, 2022
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1CGP
 | | CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA (5'-D(*GP*CP*GP*AP*AP*AP*AP*GP*TP*GP*TP*GP*AP*CP*AP*TP*AP*T)-3'), DNA (5'-D(*GP*TP*CP*AP*CP*AP*CP*TP*TP*TP*TP*CP*G)-3'), ... | | 著者 | Schultz, S.C, Shields, G.C, Steitz, T.A. | | 登録日 | 1991-08-12 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees.
Science, 253, 1991
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1O3Q
 | | PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES | | 分子名称: | 5'-D(*AP*AP*AP*AP*AP*TP*GP*TP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*AP*CP*AP*TP*TP*TP*TP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | | 著者 | Chen, S, Vojtechovsky, J, Parkinson, G.N, Ebright, R.H, Berman, H.M. | | 登録日 | 2003-03-18 | | 公開日 | 2003-04-08 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Indirect Readout of DNA Sequence at the Primary-kink Site in the CAP-DNA Complex: DNA Binding Specificity Based on Energetics of DNA Kinking
J.Mol.Biol., 314, 2001
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1O3R
 | | PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES | | 分子名称: | 5'-D(*AP*AP*AP*AP*AP*TP*GP*CP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*GP*CP*AP*TP*TP*TP*TP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | | 著者 | Chen, S, Vojtechovsky, J, Parkinson, G.N, Ebright, R.H, Berman, H.M. | | 登録日 | 2003-03-18 | | 公開日 | 2003-04-08 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Indirect Readout of DNA Sequence at the Primary-kink Site in the CAP-DNA Complex: DNA Binding Specificity Based on Energetics of DNA Kinking
J.Mol.Biol., 314, 2001
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4MGZ
 | | Selective activation of Epac1 and Epac2 | | 分子名称: | (2S,4aR,6R,7R,7aS)-6-[6-amino-8-(benzylsulfanyl)-9H-purin-9-yl]-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ... | | 著者 | Rehmann, H. | | 登録日 | 2013-08-29 | | 公開日 | 2014-09-03 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Selective activation of Epac1 and Epac2
To be Published
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1O3S
 | | PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES | | 分子名称: | 5'-D(*AP*AP*AP*AP*AP*TP*GP*CP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*GP*CP*AP*TP*TP*TP*TP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | | 著者 | Chen, S, Ebright, R.H, Berman, H.M. | | 登録日 | 2003-03-18 | | 公開日 | 2003-04-08 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Indirect Readout of DNA Sequence at the Primary-kink Site in the CAP-DNA Complex: Alteration of DNA Binding Specificity Through Alteration of DNA Kinking
J.Mol.Biol., 314, 2001
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7W5Z
 | | Cryo-EM structure of Tetrahymena thermophila mitochondrial complex IV, composite dimer model | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-oxoglutarate/malate carrier protein, CARDIOLIPIN, ... | | 著者 | Zhou, L, Maldonado, M, Padavannil, A, Letts, J. | | 登録日 | 2021-11-30 | | 公開日 | 2022-04-06 | | 最終更新日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | Structures of Tetrahymena 's respiratory chain reveal the diversity of eukaryotic core metabolism.
Science, 376, 2022
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8IO3
 | | Cryo-EM structure of human HCN3 channel with cilobradine | | 分子名称: | 3-[[(3~{S})-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1~{H}-3-benzazepin-4-one, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | | 著者 | Yu, B, Lu, Q.Y, Li, J, Zhang, J. | | 登録日 | 2023-03-10 | | 公開日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | Cryo-EM structure of human HCN3 channel with cilobradine
To Be Published
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7RHL
 | | Cryo-EM structure of human rod Apo CNGA1/B1 channel with CLZ coiled coil | | 分子名称: | Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | | 著者 | Xue, J, Han, Y, Jiang, Y. | | 登録日 | 2021-07-17 | | 公開日 | 2021-11-03 | | 最終更新日 | 2022-01-19 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel.
Neuron, 110, 2022
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6UQF
 | | Human HCN1 channel in a hyperpolarized conformation | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, MERCURY (II) ION, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | | 著者 | Lee, C.-H, MacKinnon, R. | | 登録日 | 2019-10-19 | | 公開日 | 2019-12-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Voltage Sensor Movements during Hyperpolarization in the HCN Channel.
Cell, 179, 2019
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2XKP
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5FET
 | | Crystal Structure of PVX_084705 in presence of Compound 2 | | 分子名称: | 4-[7-[(dimethylamino)methyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-amine, cGMP-dependent protein kinase, putative | | 著者 | Wernimont, A.K, Tempel, W, Walker, J.R, He, H, Seitova, A, Hills, T, Neculai, A.M, Baker, D.A, Flueck, C, Kettleborough, C.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, El Bakkouri, M, Structural Genomics Consortium (SGC) | | 登録日 | 2015-12-17 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | | 主引用文献 | Crystal Structure of PVX_084705 in presence of Compound 2
To be published
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8OTX
 | | Cryo-EM structure of Strongylocentrotus purpuratus sperm-specific Na+/H+ exchanger SLC9C1 in nanodisc | | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, Sperm-specific sodium proton exchanger | | 著者 | Yeo, H, Mehta, V, Gulati, A, Drew, D. | | 登録日 | 2023-04-21 | | 公開日 | 2023-11-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Structure and electromechanical coupling of a voltage-gated Na + /H + exchanger.
Nature, 623, 2023
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8IWO
 | | The rice Na+/H+ antiporter SOS1 in an auto-inhibited state | | 分子名称: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl tetradecanoate, OsSOS1 | | 著者 | Zhang, X.Y, Tang, L.H, Zhang, C.R, Nie, J.W. | | 登録日 | 2023-03-30 | | 公開日 | 2023-11-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | | 主引用文献 | Structure and activation mechanism of the rice Salt Overly Sensitive 1 (SOS1) Na + /H + antiporter.
Nat.Plants, 9, 2023
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3TNQ
 | | Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Protein kinase, ... | | 著者 | Zhang, P, Smith-Nguyen, E.V, Keshwani, M.M, Deal, M.S, Kornev, A.P, Taylor, S.S. | | 登録日 | 2011-09-01 | | 公開日 | 2012-02-01 | | 最終更新日 | 2012-09-26 | | 実験手法 | X-RAY DIFFRACTION (3.097 Å) | | 主引用文献 | Structure and allostery of the PKA RIIbeta tetrameric holoenzyme
Science, 335, 2012
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8JEC
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