7POJ
| Prodomain bound BMP10 crystal form 2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Bone morphogenetic protein 10, TETRAETHYLENE GLYCOL | Authors: | Guo, J, Yu, M, Li, W. | Deposit date: | 2021-09-09 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun, 13, 2022
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7PPC
| Ternary signalling complex of BMP10 bound to ALK1 and BMPRII | Descriptor: | Bone morphogenetic protein 10, Bone morphogenetic protein receptor type-2, Serine/threonine-protein kinase receptor R3 | Authors: | Guo, J, Yu, M, Read, R.J, Li, W. | Deposit date: | 2021-09-13 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun, 13, 2022
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6Q2O
| Cryo-EM structure of RET/GFRa2/NRTN extracellular complex. The 3D refinement was applied with C2 symmetry. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha-2, ... | Authors: | Li, J, Shang, G.J, Chen, Y.J, Brautigam, C.A, Liou, J, Zhang, X.W, Bai, X.C. | Deposit date: | 2019-08-08 | Release date: | 2019-10-02 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands. Elife, 8, 2019
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6Q2S
| Cryo-EM structure of RET/GFRa3/ARTN extracellular complex. The 3D refinement was applied with C2 symmetry. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha-3, ... | Authors: | Li, J, Shang, G.J, Chen, Y.J, Brautigam, C.A, Liou, J, Zhang, X.W, Bai, X.C. | Deposit date: | 2019-08-08 | Release date: | 2019-10-02 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands. Elife, 8, 2019
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7Y1R
| Human L-TGF-beta1 in complex with the anchor protein LRRC33 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Duan, Z, Zhang, Z. | Deposit date: | 2022-06-08 | Release date: | 2022-08-31 | Last modified: | 2022-09-07 | Method: | ELECTRON MICROSCOPY (4.01 Å) | Cite: | Specificity of TGF-beta 1 signal designated by LRRC33 and integrin alpha V beta 8. Nat Commun, 13, 2022
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6Q2J
| Cryo-EM structure of extracellular dimeric complex of RET/GFRAL/GDF15 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha-like, ... | Authors: | Li, J, Shang, G.J, Chen, Y.J, Brautigam, C.A, Liou, J, Zhang, X.W, Bai, X.C. | Deposit date: | 2019-08-08 | Release date: | 2019-10-02 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands. Elife, 8, 2019
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5NXS
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6Q2R
| Cryo-EM structure of RET/GFRa2/NRTN extracellular complex in the tetrameric form | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha-2, ... | Authors: | Li, J, Shang, G.J, Chen, Y.J, Brautigam, C.A, Liou, J, Zhang, X.W, Bai, X.C. | Deposit date: | 2019-08-08 | Release date: | 2019-10-02 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands. Elife, 8, 2019
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6Q2N
| Cryo-EM structure of RET/GFRa1/GDNF extracellular complex | Descriptor: | CALCIUM ION, GDNF family receptor alpha-1, Glial cell line-derived neurotrophic factor, ... | Authors: | Li, J, Shang, G.J, Chen, Y.J, Brautigam, C.A, Liou, J, Zhang, X.W, Bai, X.C. | Deposit date: | 2019-08-08 | Release date: | 2019-10-02 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands. Elife, 8, 2019
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5HZW
| Crystal structure of the orphan region of human endoglin/CD105 in complex with BMP9 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Growth/differentiation factor 2, Maltose-binding periplasmic protein,Endoglin, ... | Authors: | Bokhove, M, Saito, T, Jovine, L. | Deposit date: | 2016-02-03 | Release date: | 2017-06-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (4.451 Å) | Cite: | Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1. Cell Rep, 19, 2017
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6Z3M
| Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) and Neogenin 1 (NEO1). | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Growth/differentiation factor 5, Neogenin, ... | Authors: | Malinauskas, T, Peer, T.V, Bishop, B, Muller, T.D, Siebold, C. | Deposit date: | 2020-05-21 | Release date: | 2020-07-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (5.501 Å) | Cite: | Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex. Proc.Natl.Acad.Sci.USA, 117, 2020
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6GL7
| Neurturin-GFRa2-RET extracellular complex | Descriptor: | GDNF family receptor alpha-2, Neurturin, Proto-oncogene tyrosine-protein kinase receptor Ret | Authors: | Bigalke, J.M, Aibara, S, Sandmark, J, Amunts, A. | Deposit date: | 2018-05-23 | Release date: | 2019-08-14 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (6.3 Å) | Cite: | Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain. Sci Adv, 5, 2019
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4UX8
| RET recognition of GDNF-GFRalpha1 ligand by a composite binding site promotes membrane-proximal self-association | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF FAMILY RECEPTOR ALPHA-1, ... | Authors: | Goodman, K, Kjaer, S, Beuron, F, Knowles, P, Nawrotek, A, Burns, E, Purkiss, A, George, R, Santoro, M, Morris, E.P, McDonald, N.Q. | Deposit date: | 2014-08-19 | Release date: | 2014-10-01 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (24 Å) | Cite: | Ret Recognition of Gdnf-Gfralpha1 Ligand by a Composite Binding Site Promotes Membrane-Proximal Self-Association. Cell Rep., 8, 2014
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1KLA
| SOLUTION STRUCTURE OF TGF-B1, NMR, MODELS 1-17 OF 33 STRUCTURES | Descriptor: | TRANSFORMING GROWTH FACTOR-BETA 1 | Authors: | Hinck, A.P, Archer, S.J, Qian, S.W, Roberts, A.B, Sporn, M.B, Weatherbee, J.A, Tsang, M.L.-S, Lucas, R, Zhang, B.-L, Wenker, J, Torchia, D.A. | Deposit date: | 1996-01-16 | Release date: | 1996-08-17 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2. Biochemistry, 35, 1996
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1KLC
| SOLUTION STRUCTURE OF TGF-B1, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | TRANSFORMING GROWTH FACTOR-BETA 1 | Authors: | Hinck, A.P, Archer, S.J, Qian, S.W, Roberts, A.B, Sporn, M.B, Weatherbee, J.A, Tsang, M.L.-S, Lucas, R, Zhang, B.-L, Wenker, J, Torchia, D.A. | Deposit date: | 1996-01-16 | Release date: | 1996-08-17 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2. Biochemistry, 35, 1996
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1KLD
| SOLUTION STRUCTURE OF TGF-B1, NMR, MODELS 18-33 OF 33 STRUCTURES | Descriptor: | TRANSFORMING GROWTH FACTOR-BETA 1 | Authors: | Hinck, A.P, Archer, S.J, Qian, S.W, Roberts, A.B, Sporn, M.B, Weatherbee, J.A, Tsang, M.L.-S, Lucas, R, Zhang, B.-L, Wenker, J, Torchia, D.A. | Deposit date: | 1996-01-16 | Release date: | 1996-08-17 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2. Biochemistry, 35, 1996
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