6Q2N

Cryo-EM structure of RET/GFRa1/GDNF extracellular complex

Summary for 6Q2N

Entry DOI	10.2210/pdb6q2n/pdb
EMDB information	20575
Descriptor	Glial cell line-derived neurotrophic factor, GDNF family receptor alpha-1, Proto-oncogene tyrosine-protein kinase receptor Ret, ... (4 entities in total)
Functional Keywords	ret, receptor tyrosine kinase, cryo-em, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	261431.83
Authors	Li, J.,Shang, G.J.,Chen, Y.J.,Brautigam, C.A.,Liou, J.,Zhang, X.W.,Bai, X.C. (deposition date: 2019-08-08, release date: 2019-10-02)
Primary citation	Li, J.,Shang, G.,Chen, Y.J.,Brautigam, C.A.,Liou, J.,Zhang, X.,Bai, X.C. Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands. Elife, 8:-, 2019 Cited by PubMed: 31535977 DOI: 10.7554/eLife.47650 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.4 Å)

Structure validation