Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Q2N

Cryo-EM structure of RET/GFRa1/GDNF extracellular complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008083	molecular_function	growth factor activity
A	0030116	molecular_function	glial cell-derived neurotrophic factor receptor binding
A	0030971	molecular_function	receptor tyrosine kinase binding
B	0008083	molecular_function	growth factor activity
B	0030116	molecular_function	glial cell-derived neurotrophic factor receptor binding
B	0030971	molecular_function	receptor tyrosine kinase binding
C	0001822	biological_process	kidney development
C	0005030	molecular_function	neurotrophin receptor activity
C	0005102	molecular_function	signaling receptor binding
C	0005178	molecular_function	integrin binding
C	0005615	cellular_component	extracellular space
C	0005768	cellular_component	endosome
C	0005771	cellular_component	multivesicular body
C	0005794	cellular_component	Golgi apparatus
C	0005886	cellular_component	plasma membrane
C	0007166	biological_process	cell surface receptor signaling pathway
C	0007399	biological_process	nervous system development
C	0008584	biological_process	male gonad development
C	0009897	cellular_component	external side of plasma membrane
C	0016167	molecular_function	glial cell-derived neurotrophic factor receptor activity
C	0016477	biological_process	cell migration
C	0019898	cellular_component	extrinsic component of membrane
C	0030182	biological_process	neuron differentiation
C	0030424	cellular_component	axon
C	0031175	biological_process	neuron projection development
C	0035860	biological_process	glial cell-derived neurotrophic factor receptor signaling pathway
C	0038023	molecular_function	signaling receptor activity
C	0038179	biological_process	neurotrophin signaling pathway
C	0043025	cellular_component	neuronal cell body
C	0043235	cellular_component	receptor complex
C	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
C	0070062	cellular_component	extracellular exosome
C	0098552	cellular_component	side of membrane
C	0098797	cellular_component	plasma membrane protein complex
D	0001822	biological_process	kidney development
D	0005030	molecular_function	neurotrophin receptor activity
D	0005102	molecular_function	signaling receptor binding
D	0005178	molecular_function	integrin binding
D	0005615	cellular_component	extracellular space
D	0005768	cellular_component	endosome
D	0005771	cellular_component	multivesicular body
D	0005794	cellular_component	Golgi apparatus
D	0005886	cellular_component	plasma membrane
D	0007166	biological_process	cell surface receptor signaling pathway
D	0007399	biological_process	nervous system development
D	0008584	biological_process	male gonad development
D	0009897	cellular_component	external side of plasma membrane
D	0016167	molecular_function	glial cell-derived neurotrophic factor receptor activity
D	0016477	biological_process	cell migration
D	0019898	cellular_component	extrinsic component of membrane
D	0030182	biological_process	neuron differentiation
D	0030424	cellular_component	axon
D	0031175	biological_process	neuron projection development
D	0035860	biological_process	glial cell-derived neurotrophic factor receptor signaling pathway
D	0038023	molecular_function	signaling receptor activity
D	0038179	biological_process	neurotrophin signaling pathway
D	0043025	cellular_component	neuronal cell body
D	0043235	cellular_component	receptor complex
D	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
D	0070062	cellular_component	extracellular exosome
D	0098552	cellular_component	side of membrane
D	0098797	cellular_component	plasma membrane protein complex
E	0005509	molecular_function	calcium ion binding
E	0007156	biological_process	homophilic cell adhesion via plasma membrane adhesion molecules
E	0016020	cellular_component	membrane
F	0005509	molecular_function	calcium ion binding
F	0007156	biological_process	homophilic cell adhesion via plasma membrane adhesion molecules
F	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CA E 2001

Chain	Residue
E	ASP266
E	SER268
E	ASP300
E	ASP302
E	ASP378

site_id	AC2
Number of Residues	6
Details	binding site for residue CA E 2002

Chain	Residue
E	ASP267
E	CA2003
E	GLU178
E	GLU232
E	ASP264
E	GLU265

site_id	AC3
Number of Residues	7
Details	binding site for residue CA E 2003

Chain	Residue
E	GLU178
E	ASN179
E	ASP230
E	GLU232
E	ASP264
E	ASP267
E	CA2002

site_id	AC4
Number of Residues	6
Details	binding site for residue CA E 2004

Chain	Residue
E	THR564
E	CYS565
E	ASP567
E	HIS569
E	GLU574
E	ASP584

site_id	AC5
Number of Residues	5
Details	binding site for residue CA F 2001

Chain	Residue
F	ASP266
F	SER268
F	ASP300
F	ASP302
F	ASP378

site_id	AC6
Number of Residues	6
Details	binding site for residue CA F 2002

Chain	Residue
F	GLU178
F	GLU232
F	ASP264
F	GLU265
F	ASP267
F	CA2003

site_id	AC7
Number of Residues	7
Details	binding site for residue CA F 2003

Chain	Residue
F	GLU178
F	ASN179
F	ASP230
F	GLU232
F	ASP264
F	ASP267
F	CA2002

site_id	AC8
Number of Residues	6
Details	binding site for residue CA F 2004

Chain	Residue
F	THR564
F	CYS565
F	ASP567
F	HIS569
F	GLU574
F	ASP584

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1212
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
E	LEU29-ARG635
F	LEU29-ARG635
C	ASN406
D	ASN59
D	ASN347
D	ASN406

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:31535977, ECO:0000305\|PubMed:25242331, ECO:0007744\|PDB:4UX8, ECO:0007744\|PDB:6Q2J

Chain	Residue	Details
E	GLU178
F	ASP230
F	ASP264
F	GLU265
F	ASP266
F	SER268
F	ASP300
F	ASP302
E	ASP230
E	ASP264
E	GLU265
E	ASP266
E	SER268
E	ASP300
E	ASP302
F	GLU178

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269\|PubMed:31535977, ECO:0007744\|PDB:6Q2J

Chain	Residue	Details
E	ASN179
E	ASP584
F	ASN179
F	GLU232
F	ASP267
F	ASP378
F	THR564
F	CYS565
F	ASP567
F	HIS569
F	GLU574
E	GLU232
F	ASP584
E	ASP267
E	ASP378
E	THR564
E	CYS565
E	ASP567
E	HIS569
E	GLU574

site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Breakpoint for translocation to form the TRIM27/RET oncogene => ECO:0000269\|PubMed:3037315

Chain	Residue	Details
E	ARG587
F	ARG587

site_id	SWS_FT_FI5
Number of Residues	22
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
E	ASN98
E	ASN468
E	ASN554
F	ASN98
F	ASN199
F	ASN336
F	ASN343
F	ASN361
F	ASN367
F	ASN377
F	ASN394
E	ASN199
F	ASN448
F	ASN468
F	ASN554
E	ASN336
E	ASN343
E	ASN361
E	ASN367
E	ASN377
E	ASN394
E	ASN448

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:20473317

Chain	Residue	Details
E	ASN151
F	ASN151

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)