6Q2N
Cryo-EM structure of RET/GFRa1/GDNF extracellular complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Glial cell line-derived neurotrophic factor | polymer | 134 | 15096.2 | 2 | UniProt (P39905) Pfam (PF00019) In PDB | Homo sapiens (Human) | hGDNF,Astrocyte-derived trophic factor,ATF |
2 | C, D | GDNF family receptor alpha-1 | polymer | 412 | 46358.6 | 2 | UniProt (P56159) Pfam (PF02351) In PDB | Homo sapiens (Human) | GFR-alpha-1,RET ligand 1,TGF-beta-related neurotrophic factor receptor 1 |
3 | E, F | Proto-oncogene tyrosine-protein kinase receptor Ret | polymer | 617 | 69100.8 | 2 | UniProt (P07949) Pfam (PF17756) Pfam (PF00028) Pfam (PF17812) Pfam (PF17813) Pfam (PF22540) In PDB | Homo sapiens (Human) | Cadherin family member 12,Proto-oncogene c-Ret |
4 | E, F | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) |
Sequence modifications
C, D: 25 - 426 (UniProt: P56159)
E, F: 29 - 635 (UniProt: P07949)
PDB | External Database | Details |
---|---|---|
Gly 427 | - | expression tag |
Thr 428 | - | expression tag |
His 429 | - | expression tag |
His 430 | - | expression tag |
His 431 | - | expression tag |
His 432 | - | expression tag |
His 433 | - | expression tag |
His 434 | - | expression tag |
His 435 | - | expression tag |
His 436 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His 114 | Arg 114 | conflict |
Gly 636 | - | expression tag |
Thr 637 | - | expression tag |
His 638 | - | expression tag |
His 639 | - | expression tag |
His 640 | - | expression tag |
His 641 | - | expression tag |
His 642 | - | expression tag |
His 643 | - | expression tag |
His 644 | - | expression tag |
His 645 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 261111.2 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 320.6 | |
All* | Total formula weight | 261431.8 |