PDB: 522 resultsInfo pagesStatus searchChemie searchBIRD

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4HVW	Crystal structure of the T98E c-Src-SH3 domain mutant in complex with the high affinity peptide VSL12 Descriptor: ACETYL GROUP, Proto-oncogene tyrosine-protein kinase Src, SULFATE ION, ... Authors: Camara-Artigas, A. Deposit date: 2012-11-07 Release date: 2013-05-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (0.98 Å) Cite: Atomic resolution structures of the c-Src SH3 domain in complex with two high-affinity peptides from classes I and II. Acta Crystallogr.,Sect.D, 69, 2013
4HVU	Crystal structure of the T98D c-Src-SH3 domain mutant in complex with the high affinity peptide APP12 Descriptor: ACETYL GROUP, Proto-oncogene tyrosine-protein kinase Src, SULFATE ION, ... Authors: Camara-Artigas, A. Deposit date: 2012-11-07 Release date: 2013-05-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (0.98 Å) Cite: Atomic resolution structures of the c-Src SH3 domain in complex with two high-affinity peptides from classes I and II. Acta Crystallogr.,Sect.D, 69, 2013
2LZ6	Distinct ubiquitin binding modes exhibited by sh3 domains: molecular determinants and functional implications Descriptor: CD2-associated protein, Ubiquitin Authors: Ortega-Roldan, J, Azuaga, A, Blackledge, M, Van Nuland, N. Deposit date: 2012-09-24 Release date: 2013-10-02 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Distinct Ubiquitin Binding Modes Exhibited by SH3 Domains: Molecular Determinants and Functional Implications. Plos One, 8, 2013
4GLM	Crystal structure of the SH3 Domain of DNMBP protein [Homo sapiens] Descriptor: Dynamin-binding protein, UNKNOWN ATOM OR ION Authors: Dong, A, Guan, X, Huang, H, Tempel, W, Gu, J, Sidhu, S, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC) Deposit date: 2012-08-14 Release date: 2012-11-21 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of the SH3 Domain of DNMBP protein [Homo sapiens] to be published
4FSS	Crystal structure of a RAS p21 protein activator (RASA1) from Homo sapiens at 2.25 A resolution Descriptor: CHLORIDE ION, GLYCEROL, PHOSPHATE ION, ... Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2012-06-27 Release date: 2012-07-18 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Crystal structure of a RAS p21 protein activator (RASA1) from Homo sapiens at 2.25 A resolution To be published
4F16	Crystal Structure of the alpha spectrin SH3 domain at pH 5 Descriptor: Spectrin alpha chain, brain Authors: Camara-Artigas, A, Gavira, J.A. Deposit date: 2012-05-06 Release date: 2013-05-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Crystal Structure of the alpha spectrin SH3 domain at pH 5 To be Published
4F17	Crystal Structure of the alpha spectrin SH3 domain at pH 9 Descriptor: Spectrin alpha chain, brain Authors: Camara-Artigas, A, Gavira, J.A. Deposit date: 2012-05-06 Release date: 2013-05-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Crystal Structure of the alpha spectrin SH3 domain at pH 9 To be Published
4ESR	Molecular and Structural Characterization of the SH3 Domain of AHI-1 in Regulation of Cellular Resistance of BCR-ABL+ Chronic Myeloid Leukemia Cells to Tyrosine Kinase Inhibitors Descriptor: DI(HYDROXYETHYL)ETHER, Jouberin Authors: Van Petegem, X.F, Liu, P.X, Lobo, P, Jiang, X. Deposit date: 2012-04-23 Release date: 2012-06-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Molecular and structural characterization of the SH3 domain of AHI-1 in regulation of cellular resistance of BCR-ABL(+) chronic myeloid leukemia cells to tyrosine kinase inhibitors. Proteomics, 12, 2012
3VS2	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Descriptor: 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... Authors: Kuratani, M, Tomabechi, Y, Niwa, H, Parker, J.L, Handa, N, Yokoyama, S. Deposit date: 2012-04-21 Release date: 2013-05-01 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.609 Å) Cite: A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VRY	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane Descriptor: 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane, CALCIUM ION, CHLORIDE ION, ... Authors: Kuratani, M, Tomabechi, Y, Niwa, H, Handa, N, Yokoyama, S. Deposit date: 2012-04-21 Release date: 2013-05-01 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.481 Å) Cite: A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS7	Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Descriptor: 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... Authors: Kuratani, M, Honda, K, Niwa, H, Toyama, M, Handa, N, Yokoyama, S. Deposit date: 2012-04-21 Release date: 2013-05-01 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (3.001 Å) Cite: A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VRZ	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea Descriptor: 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea, CALCIUM ION, CHLORIDE ION, ... Authors: Kuratani, M, Tomabechi, Y, Handa, N, Yokoyama, S. Deposit date: 2012-04-21 Release date: 2013-05-01 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.218 Å) Cite: A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS1	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea Descriptor: 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea, CALCIUM ION, CHLORIDE ION, ... Authors: Kuratani, M, Tomabechi, Y, Toyama, M, Handa, N, Yokoyama, S. Deposit date: 2012-04-21 Release date: 2013-05-01 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.464 Å) Cite: A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS4	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Descriptor: 5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... Authors: Kuratani, M, Tomabechi, Y, Handa, N, Yokoyama, S. Deposit date: 2012-04-21 Release date: 2013-05-01 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.747 Å) Cite: A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS0	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide Descriptor: CALCIUM ION, CHLORIDE ION, N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide, ... Authors: Kuratani, M, Honda, K, Tomabechi, Y, Handa, N, Yokoyama, S. Deposit date: 2012-04-21 Release date: 2013-05-01 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.934 Å) Cite: A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS3	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Descriptor: 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... Authors: Kuratani, M, Tomaebchi, Y, Handa, N, Yokoyama, S. Deposit date: 2012-04-21 Release date: 2013-05-01 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.17 Å) Cite: A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS5	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Descriptor: 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, Tyrosine-protein kinase HCK Authors: Kuratani, M, Tomabechi, Y, Handa, N, Yokoyama, S. Deposit date: 2012-04-21 Release date: 2013-05-01 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.851 Å) Cite: A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS6	Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor tert-butyl {4-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate Descriptor: CALCIUM ION, CHLORIDE ION, Tyrosine-protein kinase HCK, ... Authors: Kuratani, M, Honda, K, Tomabechi, Y, Toyama, M, Handa, N, Yokoyama, S. Deposit date: 2012-04-21 Release date: 2013-05-01 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.373 Å) Cite: A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
4EIK	Crystal Structure of the Human Fyn SH3 domain in complex with the synthetic peptide VSL12 Descriptor: SODIUM ION, Tyrosine-protein kinase Fyn, VSL12 peptide Authors: Camara-Artigas, A. Deposit date: 2012-04-05 Release date: 2013-04-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystallization of and selenomethionine phasing strategy for a SETMAR-DNA complex. Acta Crystallogr F Struct Biol Commun, 72, 2016
2LQW	Solution structure of phosphorylated CRKL Descriptor: Crk-like protein Authors: Jankowski, W, Saleh, T, Kalodimos, C. Deposit date: 2012-03-16 Release date: 2012-05-16 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII. Nat.Chem.Biol., 8, 2012
2LQN	Solution structure of CRKL Descriptor: Crk-like protein Authors: Jankowski, W, Saleh, T, Kalodimos, C. Deposit date: 2012-03-09 Release date: 2012-05-16 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII. Nat.Chem.Biol., 8, 2012
2LP5	Native Structure of the Fyn SH3 A39V/N53P/V55L Descriptor: Tyrosine-protein kinase Fyn Authors: Neudecker, P, Robustelli, P, Cavalli, A, Vendruscolo, M, Kay, L.E. Deposit date: 2012-02-06 Release date: 2012-05-16 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structure of an intermediate state in protein folding and aggregation. Science, 336, 2012
4D8D	Crystal structure of HIV-1 NEF Fyn-SH3 R96W variant Descriptor: GLYCEROL, Protein Nef, Tyrosine-protein kinase Fyn Authors: Arold, S.T, Hoh, F, Dumas, C. Deposit date: 2012-01-10 Release date: 2013-01-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.5201 Å) Cite: Synergy and allostery in ligand binding by HIV-1 Nef. Biochem.J., 478, 2021
4D8K	Crystal structure of a SH3-SH2 domains of a lymphocyte-specific protein tyrosine kinase (LCK) from Homo sapiens at 2.36 A resolution Descriptor: GLYCEROL, SULFATE ION, Tyrosine-protein kinase Lck Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2012-01-10 Release date: 2012-01-25 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.36 Å) Cite: Crystal structure of a SH3-SH2 domains of a lymphocyte-specific protein tyrosine kinase (LCK) from Homo sapiens at 2.36 A resolution To be published
2LMJ	Itk-sh3 Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Kristiansen, P, Bie Andersen, T, Huszenicza, Z, Andreotti, A.H, Spurkland, A. Deposit date: 2011-12-05 Release date: 2012-12-05 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: The SH3 domains of the Tec family kinase Itk and the Src family kinase Lck compete for adjacent sites on T-cell specific adapter protein To be Published

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