PDB: 593 resultsInfo pagesStatus searchChemie searchBIRD

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3KFJ	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ... Authors: Clements, J.H. Deposit date: 2009-10-27 Release date: 2010-03-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Thermodynamic and structural effects of conformational constraints in protein-ligand interactions. Entropic paradoxy associated with ligand preorganization. J.Am.Chem.Soc., 131, 2009
3WA4	Grb2 SH2 domain/CD28-derived peptide complex Descriptor: ACETIC ACID, CADMIUM ION, Growth factor receptor-bound protein 2, ... Authors: Higo, K, Oda, M, Ito, N. Deposit date: 2013-04-23 Release date: 2014-02-26 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.35 Å) Cite: High Resolution Crystal Structure of the Grb2 SH2 Domain with a Phosphopeptide Derived from CD28 Plos One, 8, 2013
3MAZ	Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide Descriptor: CheD family protein, MALONATE ION, Signal-transducing adaptor protein 1 Authors: Kaneko, T, Huang, H, Zhao, B, Li, L, Liu, H, Voss, C.K, Wu, C, Schiller, M.R, Li, S.S. Deposit date: 2010-03-24 Release date: 2010-05-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Loops govern SH2 domain specificity by controlling access to binding pockets. Sci.Signal., 3, 2010
3MXC	Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. Descriptor: AICD peptide, Growth factor receptor-bound protein 2 Authors: Sen, U, Das, S. Deposit date: 2010-05-07 Release date: 2011-05-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414, 2011
3MXY	Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. Descriptor: AICD peptide E683V variant, Growth factor receptor-bound protein 2 Authors: Sen, U, Das, S. Deposit date: 2010-05-08 Release date: 2011-05-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414, 2011
3N84	Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP Descriptor: 23-membered peptide-like macrocyclic ligand, CHLORIDE ION, GLYCEROL, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-05-27 Release date: 2011-01-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3N8M	Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP Descriptor: GLYCEROL, Growth factor receptor-bound protein 2, PEPTIDE Authors: Whiddon, B.B, Clements, J.H, Martin, S.F. Deposit date: 2010-05-28 Release date: 2010-12-15 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
5JN0	CRK-II SH2 domain Descriptor: CHLORIDE ION, CRK-II SH2 domain Authors: Cho, J.-H. Deposit date: 2016-04-29 Release date: 2017-08-09 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.677 Å) Cite: CRK-II SH2 domain To Be Published
3N7Y	Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV Descriptor: 20-membered peptide-like macrocyclic ligand, Growth factor receptor-bound protein 2 Authors: Whiddon, B.B, Clements, J.H, Martin, S.F. Deposit date: 2010-05-27 Release date: 2011-01-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3OV1	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: FORMIC ACID, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-15 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3OVE	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, PYAC7CN Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-16 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
8ATK	The SH2 domain of mouse SH2B1 Descriptor: SH2B adapter protein 1 Authors: Fowler, N.J, Williamson, M.P, Albalwi, M.F. Deposit date: 2022-08-23 Release date: 2023-05-24 Last modified: 2023-08-16 Method: SOLUTION NMR Cite: Improved methodology for protein NMR structure calculation using hydrogen bond restraints and ANSURR validation: The SH2 domain of SH2B1. Structure, 31, 2023
7RNV	SH2 domain of guanine nucleotide exchange factor Vav2 in complex with an actin peptide with phosphorylated tyrosine 53 Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ... Authors: Dai, S, Horton, J.R, Cheng, X. Deposit date: 2021-07-29 Release date: 2021-08-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.15 Å) Cite: The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin To Be Published
7RNS	nSH2 domain of p85-alpha subunit of phosphatidylinositol 3-kinase in complex with an actin peptide with phosphorylated tyrosine 53 Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ... Authors: Dai, S, Horton, J.R, Cheng, X. Deposit date: 2021-07-29 Release date: 2021-08-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.14 Å) Cite: The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin To Be Published
7RNU	nSH2 domain of p85-beta subunit of phosphatidylinositol 3-kinase in complex with an actin peptide with phosphorylated tyrosine 53 Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ... Authors: Dai, S, Horton, J.R, Cheng, X. Deposit date: 2021-07-29 Release date: 2021-08-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.45 Å) Cite: The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin To Be Published
4P9V	Grb2 SH2 complexed with a pTyr-Ac6cN-Asn tripeptide Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, PHQ-PTR-02K-ASN-NH2 Authors: Clements, J.H, Martin, S.F. Deposit date: 2014-04-06 Release date: 2014-06-18 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction. Bioorg.Med.Chem.Lett., 24, 2014
7R8X	Crystal Structure of the LNK SH2 Domain in Complex with an EPOR pY454 Phosphopeptide Descriptor: EPOR pY454 phosphopeptide, SH2B adapter protein 3 Authors: Morris, R, Kershaw, N.J, Babon, J.J. Deposit date: 2021-06-27 Release date: 2021-10-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nat Commun, 12, 2021
7R8W	Crystal Structure of the LNK SH2 Domain in Complex with a JAK2 pY813 Phosphopeptide Descriptor: JAK2 pY813 phosphopeptide, SH2B adapter protein 3 Authors: Morris, R, Kershaw, N.J, Babon, J.J. Deposit date: 2021-06-27 Release date: 2021-10-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nat Commun, 12, 2021
4P9Z	Grb2 SH2 complexed with a pTyr-Ac6c-Asn tripeptide Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2014-04-06 Release date: 2014-06-18 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction. Bioorg.Med.Chem.Lett., 24, 2014
7SA7	Crystal structure of the apo SH2 domains of Syk Descriptor: Tyrosine-protein kinase SYK Authors: Hobbs, H.T, Badroos, J, Gee, C.L, Kuriyan, J. Deposit date: 2021-09-22 Release date: 2021-10-13 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases. Protein Sci., 30, 2021
6E8M	Legionella Longbeachae LeSH (Llo2327) bound to the human DnaJ-A1 pTyr381 peptide Descriptor: DnaJ-A1 pTyr381 peptide, LeSH (Llo2327) Authors: Kaneko, T, Li, S.S.C. Deposit date: 2018-07-30 Release date: 2018-11-14 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6E8I	Legionella Longbeachae LeSH (Llo2327) bound to phosphotyrosine Descriptor: LeSH (Llo2327), O-PHOSPHOTYROSINE Authors: Kaneko, T, Li, S.S.C. Deposit date: 2018-07-29 Release date: 2018-11-14 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6E8H	Legionella Longbeachae LeSH (Llo2327) Descriptor: CHLORIDE ION, LeSH (Llo2327) Authors: Kaneko, T, Li, S.S.C. Deposit date: 2018-07-29 Release date: 2018-11-14 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6E8K	Legionella Longbeachae LeSH (Llo2327) bound to the human interleukin-2 receptor beta pTyr387 peptide Descriptor: LeSH (Llo2327), interleukin-2 receptor beta pTyr387 peptide Authors: Kaneko, T, Li, S.S.C. Deposit date: 2018-07-30 Release date: 2018-11-14 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
4QSY	SHP2 SH2 domain in complex with GAB1 peptide Descriptor: GRB2-associated-binding protein 1, Tyrosine-protein phosphatase non-receptor type 11 Authors: Gogl, G, Remenyi, A. Deposit date: 2014-07-06 Release date: 2015-07-08 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Selective targeting of GAB adapter protein SHP2 tyrosine phosphatase interaction attenuates ERK signaling To be Published

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