PDB: 593 件ウェブページステータス検索Chemie searchBIRD

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5VKO	SPT6 tSH2-RPB1 1468-1500 pT1471, pS1493 分子名称: DNA-directed RNA polymerase II subunit RPB1, ISOPROPYL ALCOHOL, Transcription elongation factor SPT6 著者 Sdano, M.A, Whitby, F.G, Hill, C.P. 登録日 2017-04-21 公開日 2017-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription. Elife, 6, 2017
2QMS	Crystal structure of a signaling molecule 分子名称: Growth factor receptor-bound protein 7, SULFATE ION 著者 Porter, C.J, Wilce, M.C, Wilce, J.A. 登録日 2007-07-16 公開日 2008-07-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation. Bmc Struct.Biol., 7, 2007
3TKZ	Structure of the SHP-2 N-SH2 domain in a 1:2 complex with RVIpYFVPLNR peptide 分子名称: PROTEIN (RVIpYFVPLNR peptide), Tyrosine-protein phosphatase non-receptor type 11 著者 Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. 登録日 2011-08-29 公開日 2011-10-26 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
3TL0	Structure of SHP2 N-SH2 domain in complex with RLNpYAQLWHR peptide 分子名称: RLNpYAQLWHR peptide, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. 登録日 2011-08-29 公開日 2011-09-28 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
8ATK	The SH2 domain of mouse SH2B1 分子名称: SH2B adapter protein 1 著者 Fowler, N.J, Williamson, M.P, Albalwi, M.F. 登録日 2022-08-23 公開日 2023-05-24 最終更新日 2023-08-16 実験手法 SOLUTION NMR 主引用文献 Improved methodology for protein NMR structure calculation using hydrogen bond restraints and ANSURR validation: The SH2 domain of SH2B1. Structure, 31, 2023
7CIO	Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase 分子名称: Cytotoxic T-lymphocyte protein 4, Phosphatidylinositol 3-kinase regulatory subunit alpha 著者 Iiyama, M, Numoto, N, Ogawa, S, Kuroda, M, Morii, H, Abe, R, Ito, N, Oda, M. 登録日 2020-07-08 公開日 2020-12-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains. Mol.Immunol., 131, 2021
6PXC	N-Terminal SH2 domain of the p120RasGAP bound to a p190RhoGAP phosphotyrosine peptide 分子名称: Ras GTPase-activating protein 1, phosphopeptide of p190RhoGAP 著者 Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J. 登録日 2019-07-25 公開日 2019-12-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide. Plos One, 14, 2019
6VK2	NMR solution structure of Grb2-SH2 domain at pH 7 分子名称: Growth factor receptor-bound protein 2 著者 Sanches, K, Caruso, I.P, Melo, F.A, Almeida, F.C.L. 登録日 2020-01-18 公開日 2020-07-29 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 The dynamics of free and phosphopeptide-bound Grb2-SH2 reveals two dynamically independent subdomains and an encounter complex with fuzzy interactions. Sci Rep, 10, 2020
6WM1	Crystal structure of the Grb2 SH2 domain in complex with a tripeptide: Ac-pY-Ac6c-N-phenylpropyl 分子名称: ACE-PTR-02K-ASN-PRA, CALCIUM ION, CHLORIDE ION, ... 著者 Martin, S.F, Clements, J.H. 登録日 2020-04-20 公開日 2020-09-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions. Eur.J.Med.Chem., 208, 2020
3C7I	X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible ligand, FPTVN. 分子名称: FORMIC ACID, Growth factor receptor-bound protein 2, N-{(2R)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-valyl-L-aspartamide 著者 Benfield, A.P, Martin, S.F. 登録日 2008-02-07 公開日 2008-08-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Ligand Preorganization May be Accompanied by Entropic Penalties in Protein-Ligand Interactions. Angew.Chem.Int.Ed.Engl., 118, 2006
6WO2	Crystal Structure of the Grb2 SH2 Domain in Complex with a Tripeptide: Ac-pY-Ac6c-N-isohexyl 分子名称: ACE-PTR-02K-ASN-U67, CALCIUM ION, Growth factor receptor-bound protein 2, ... 著者 Martin, S.F, Clements, J.H. 登録日 2020-04-24 公開日 2020-09-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions. Eur.J.Med.Chem., 208, 2020
6PXB	N-Terminal SH2 domain of the p120RasGAP 分子名称: Ras GTPase-activating protein 1 著者 Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J. 登録日 2019-07-25 公開日 2019-12-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.747 Å) 主引用文献 Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide. Plos One, 14, 2019
3EAC	Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), Oxidized form. 分子名称: Tyrosine-protein kinase CSK 著者 Liu, D, Seidel, R.D, Cowburn, D. 登録日 2008-08-25 公開日 2009-11-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase. Biophys Rep, 2, 2016
2YSX	Solution structure of the human SHIP SH2 domain 分子名称: Signaling inositol polyphosphate phosphatase SHIP II 著者 Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-04-04 公開日 2008-04-08 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 Solution structure of the human SHIP SH2 domain To be Published
2EU0	The NMR ensemble structure of the Itk SH2 domain bound to a phosphopeptide 分子名称: Lymphocyte cytosolic protein 2 phosphopeptide fragment, Tyrosine-protein kinase ITK/TSK 著者 Sundd, M, Pletneva, E.V, Fulton, D.B, Andreotti, A.H. 登録日 2005-10-27 公開日 2006-02-07 最終更新日 2022-03-09 実験手法 SOLUTION NMR 主引用文献 Molecular Details of Itk Activation by Prolyl Isomerization and Phospholigand Binding: The NMR Structure of the Itk SH2 Domain Bound to a Phosphopeptide. J.Mol.Biol., 357, 2006
5D0J	Grb7 SH2 with inhibitor peptide 分子名称: G7-TEdFP peptide, Growth factor receptor-bound protein 7, PHOSPHATE ION 著者 Gunzburg, M.J, Watson, G.M, Wilce, J.A, Wilce, M.C.J. 登録日 2015-08-03 公開日 2016-06-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
5DF6	Crystal structure of PTPN11 tandem SH2 domains in complex with a TXNIP peptide 分子名称: Tyrosine-protein phosphatase non-receptor type 11, UNKNOWN ATOM OR ION, txnip 著者 Dong, A, Li, W, Tempel, W, Liu, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2015-08-26 公開日 2015-09-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP. Biochem.J., 473, 2016
3EAZ	Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), C122S mutant. 分子名称: Tyrosine-protein kinase CSK 著者 Liu, D, Seidel, R.D, Cowburn, D. 登録日 2008-08-26 公開日 2009-11-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase. Biophys Rep, 2, 2016
6R5G	C-SH2 domain of SHP-2 in complex with phospho-ITSM of PD-1 分子名称: ITSM, Tyrosine-protein phosphatase non-receptor type 11 著者 Marasco, M. 登録日 2019-03-25 公開日 2020-02-05 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020
2FCI	Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase 分子名称: C-termainl SH2 domain from phospholipase C-gamma-1 comprising residues 663-759, Doubly phosphorylated peptide derived from Syk kinase comprising residues 338-350 著者 Groesch, T.D, Zhou, F, Mattila, S, Geahlen, R.L, Post, C.B. 登録日 2005-12-12 公開日 2006-01-31 最終更新日 2023-11-15 実験手法 SOLUTION NMR 主引用文献 Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by syk tyrosine kinase J.Mol.Biol., 356, 2006
6ROZ	Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based switch motif 分子名称: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based switch motif (ITSM) 著者 Krausze, J, Sikorska, J, Carlomagno, T. 登録日 2019-05-13 公開日 2020-02-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020
6ROY	Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based inhibitory motif 分子名称: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based inhibitory motif (ITIM) 著者 Krausze, J, Sikorska, J, Carlomagno, T. 登録日 2019-05-13 公開日 2020-02-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020
6SM5	MbC/SHP1-C-SH2 complex 分子名称: MbC (monobody targeting SHP1-C-SH2), Tyrosine-protein phosphatase non-receptor type 6 著者 Mann, G, Hantschel, O. 登録日 2019-08-21 公開日 2021-01-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 MbC/SHP1-C-SH2 complex To Be Published
2YU7	Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A 分子名称: Tyrosine-protein phosphatase non-receptor type 6, natural killer group 2A 著者 Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-04-05 公開日 2008-04-15 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A To be Published
6WAY	C-terminal SH2 domain of p120RasGAP in complex with p190RhoGAP phosphotyrosine peptide 分子名称: Ras GTPase-activating protein 1, Rho GTPase-activating protein 35 著者 Jaber Chehayeb, R, Wang, J, Stiegler, A.L, Boggon, T.J. 登録日 2020-03-26 公開日 2020-06-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain. J.Biol.Chem., 295, 2020

 

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