PDB: 495 resultsInfo pagesStatus searchChemie searchBIRD

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3QYZ	Crystal structure of ERK2 in complex with an inhibitor Descriptor: 5'-azido-8-bromo-5'-deoxyadenosine, BETA-MERCAPTOETHANOL, DIMETHYL SULFOXIDE, ... Authors: Gelin, M, Pochet, S, Hoh, F, Pirochi, M, Guichou, J.-F, Ferrer, J.-L, Labesse, G. Deposit date: 2011-03-04 Release date: 2011-08-24 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (1.46 Å) Cite: In-plate protein crystallization, in situ ligand soaking and X-ray diffraction. Acta Crystallogr.,Sect.D, 67, 2011
3QYW	Crystal structure of ERK2 in complex with an inhibitor Descriptor: 6-(3-bromophenyl)-7H-purin-2-amine, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... Authors: Gelin, M, Pochet, S, Hoh, F, Pirochi, M, Guichou, J.-F, Ferrer, J.-L, Labesse, G. Deposit date: 2011-03-04 Release date: 2011-08-24 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (1.5 Å) Cite: In-plate protein crystallization, in situ ligand soaking and X-ray diffraction. Acta Crystallogr.,Sect.D, 67, 2011
3PP1	Crystal Structure of the Human Mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgATP Descriptor: 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Dougan, D.R. Deposit date: 2010-11-23 Release date: 2011-02-23 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer. Bioorg.Med.Chem.Lett., 21, 2011
3P0A	X-ray structure of pentameric HIV-1 CA Descriptor: HIV-1 CA Authors: Pornillos, O. Deposit date: 2010-09-27 Release date: 2011-01-12 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (5.954 Å) Cite: Atomic-level modelling of the HIV capsid. Nature, 469, 2011
3P05	X-ray structure of pentameric HIV-1 CA Descriptor: HIV-1 CA, IODIDE ION Authors: Pornillos, O. Deposit date: 2010-09-27 Release date: 2011-01-12 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Atomic-level modelling of the HIV capsid. Nature, 469, 2011
3OS3	Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4858061 and MgATP Descriptor: 2-[(4-ethynyl-2-fluorophenyl)amino]-3,4-difluoro-N-(2-hydroxyethoxy)-5-{[(2-hydroxyethoxy)imino]methyl}benzamide, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Lukacs, C.M, Janson, C, Schuck, V, Belunis, C. Deposit date: 2010-09-08 Release date: 2011-07-27 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent. Bioorg.Med.Chem.Lett., 21, 2011
3ORN	Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4987655 and MgAMP-PNP Descriptor: 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(3-oxo-1,2-oxazinan-2-yl)methyl]benzamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... Authors: Lukacs, C.M, Janson, C, Schuck, V, Belunis, C. Deposit date: 2010-09-07 Release date: 2011-03-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent. Bioorg.Med.Chem.Lett., 21, 2011
3O71	Crystal structure of ERK2/DCC peptide complex Descriptor: Mitogen-activated protein kinase 1, Peptide of Deleted in Colorectal Cancer, THIOCYANATE ION Authors: Ma, W.F, Shang, Y, Wei, Z.Y, Wen, W.Y, Wang, W.N, Zhang, M.J. Deposit date: 2010-07-30 Release date: 2011-06-15 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Phosphorylation of DCC by ERK2 is facilitated by direct docking of the receptor P1 domain to the kinase Structure, 18, 2010
3MGE	X-ray Structure of Hexameric HIV-1 CA Descriptor: 1,2-ETHANEDIOL, Capsid protein p24 Authors: Pornillos, O. Deposit date: 2010-04-05 Release date: 2010-07-21 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Disulfide Bond Stabilization of the Hexameric Capsomer of Human Immunodeficiency Virus. J.Mol.Biol., 401, 2010
3MBL	Crystal Structure of the human mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgADP Descriptor: 5-acetyl-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrole-3-carboxamide, ADENOSINE-5'-DIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Dougan, D.R, Mol, C.D. Deposit date: 2010-03-25 Release date: 2010-07-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
3M94	Complex crystal structure of Ascaris suum eIF4E-3 with m2,2,7G cap Descriptor: ACETYL GROUP, Eukaryotic translation initiation factor 4E-binding protein 1, N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate), ... Authors: Liu, W, Berkeley Structural Genomics Center (BSGC) Deposit date: 2010-03-19 Release date: 2011-07-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiation. Nucleic Acids Res., 39, 2011
3M93	Complex crystal structure of Ascaris suum eIF4E-3 with m7G cap Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, Translation initiation factor 4E Authors: Liu, W, Berkeley Structural Genomics Center (BSGC) Deposit date: 2010-03-19 Release date: 2011-07-20 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiation. Nucleic Acids Res., 39, 2011
3KN6	Crystal structure of the C-terminal kinase domain of MSK1 Descriptor: Ribosomal protein S6 kinase alpha-5 Authors: D'Angelo, I, Malakhova, M, Dong, Z. Deposit date: 2009-11-12 Release date: 2010-04-21 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1. J.Mol.Biol., 399, 2010
3KN5	Crystal structure of the C-terminal kinase domain of msk1 in complex with AMP-PNP Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-5 Authors: D'Angelo, I, Malakhova, M, Dong, Z. Deposit date: 2009-11-12 Release date: 2010-04-21 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1. J.Mol.Biol., 399, 2010
3I60	Crystal structure of ERK2 bound to (S)-4-(2-(2-chlorophenylamino)-5-methylpyrimidin-4-yl)-N-(2-hydroxy-1-phenylethyl)-1H-pyrrole-2-carboxamide Descriptor: 4-{2-[(2-chlorophenyl)amino]-5-methylpyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-phenylethyl]-1H-pyrrole-2-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION Authors: Jacobs, M.D, Xie, X. Deposit date: 2009-07-06 Release date: 2010-01-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. J.Med.Chem., 52, 2009
3I5Z	Crystal structure of ERK2 bound to (S)-N-(2-hydroxy-1-phenylethyl)-4-(5-methyl-2-(phenylamino)pyrimidin-4-yl)-1H-pyrrole-2-carboxamide Descriptor: Mitogen-activated protein kinase 1, N-[(1S)-2-hydroxy-1-phenylethyl]-4-[5-methyl-2-(phenylamino)pyrimidin-4-yl]-1H-pyrrole-2-carboxamide, SULFATE ION Authors: Jacobs, M.D, Xie, X. Deposit date: 2009-07-06 Release date: 2010-01-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. J.Med.Chem., 52, 2009
3HXI	Crystal structure of Schistosome eIF4E complexed with m7GpppG and 4E-BP Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Eukaryotic Translation Initiation 4E, Eukaryotic translation initiation factor 4E-binding protein 1 Authors: Liu, W, Zhao, R, Jones, D.N.M, Davis, R.E. Deposit date: 2009-06-20 Release date: 2009-08-25 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural insights into parasite EIF4E binding specificity for m7G and m2,2,7G mRNA cap. J.Biol.Chem., 284, 2009
3HXG	Crystal structure of Schistsome eIF4E complexed with m7GpppA and 4E-BP Descriptor: Eukaryotic Translation Initiation Factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE Authors: Liu, W, Zhao, R, Jones, D.N.M, Davis, R.E. Deposit date: 2009-06-20 Release date: 2009-08-25 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural insights into parasite EIF4E binding specificity for m7G and m2,2,7G mRNA cap. J.Biol.Chem., 284, 2009
3H85	Molecular basis for the association of PIPKI gamma-p90 with the clathrin adaptor AP-2 Descriptor: AP-2 complex subunit mu-1, NICKEL (II) ION, Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma Authors: Vahedi-Faridi, A, Kahlfeldt, N, Schaefer, J.G, Haucke, V. Deposit date: 2009-04-28 Release date: 2009-11-24 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2. J.Biol.Chem., 285, 2010
3H4E	X-ray Structure of Hexameric HIV-1 CA Descriptor: Capsid protein p24 Authors: Pornillos, O. Deposit date: 2009-04-19 Release date: 2009-06-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.704 Å) Cite: X-ray structures of the hexameric building block of the HIV capsid. Cell(Cambridge,Mass.), 137, 2009
3H47	X-ray Structure of Hexameric HIV-1 CA Descriptor: Capsid protein p24 Authors: Pornillos, O. Deposit date: 2009-04-18 Release date: 2009-06-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: X-ray structures of the hexameric building block of the HIV capsid. Cell(Cambridge,Mass.), 137, 2009
3H1Z	Molecular basis for the association of PIPKIgamma -p90 with the clathrin adaptor AP-2 Descriptor: AP-2 complex subunit beta-1, Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma Authors: Vahedi-Faridi, A, Kahlfeldt, N, Schaefer, J.G, Krainer, G, Keller, S, Saenger, W, Krauss, M, Haucke, V. Deposit date: 2009-04-14 Release date: 2009-11-24 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2. J.Biol.Chem., 285, 2010
3GV2	X-ray Structure of Hexameric HIV-1 CA Descriptor: Capsid protein p24,Carbon dioxide-concentrating mechanism protein CcmK homolog 4 Authors: Kelly, B.N. Deposit date: 2009-03-30 Release date: 2009-06-23 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (7 Å) Cite: X-ray structures of the hexameric building block of the HIV capsid. Cell(Cambridge,Mass.), 137, 2009
3EQI	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ADP and MG2P Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Fischmann, T.O. Deposit date: 2008-09-30 Release date: 2009-02-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
3EQH	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with U0126, ADP and MG2P Descriptor: (2Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... Authors: Fischmann, T.O. Deposit date: 2008-09-30 Release date: 2009-02-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009

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