3OS3
Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4858061 and MgATP
Summary for 3OS3
Entry DOI | 10.2210/pdb3os3/pdb |
Related | 3ORN |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 1, ADENOSINE-5'-TRIPHOSPHATE, 2-[(4-ethynyl-2-fluorophenyl)amino]-3,4-difluoro-N-(2-hydroxyethoxy)-5-{[(2-hydroxyethoxy)imino]methyl}benzamide, ... (5 entities in total) |
Functional Keywords | kinase, kinase inhibitor, allosteric, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens More |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q02750 |
Total number of polymer chains | 1 |
Total formula weight | 35208.29 |
Authors | Lukacs, C.M.,Janson, C.,Schuck, V.,Belunis, C. (deposition date: 2010-09-08, release date: 2011-07-27, Last modification date: 2024-02-21) |
Primary citation | Isshiki, Y.,Kohchi, Y.,Iikura, H.,Matsubara, Y.,Asoh, K.,Murata, T.,Kohchi, M.,Mizuguchi, E.,Tsujii, S.,Hattori, K.,Miura, T.,Yoshimura, Y.,Aida, S.,Miwa, M.,Saitoh, R.,Murao, N.,Okabe, H.,Belunis, C.,Janson, C.,Lukacs, C.,Schuck, V.,Shimma, N. Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent. Bioorg.Med.Chem.Lett., 21:1795-1801, 2011 Cited by PubMed: 21316218DOI: 10.1016/j.bmcl.2011.01.062 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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