3OS3
Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4858061 and MgATP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 307 | 34239.4 | 1 | UniProt (Q02750) Pfam (PF00069) | Homo sapiens | MAP kinase kinase 1, MAPKK 1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK 1 |
| 2 | B (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 3 | C (A) | 2-[(4-ethynyl-2-fluorophenyl)amino]-3,4-difluoro-N-(2-hydroxyethoxy)-5-{[(2-hydroxyethoxy)imino]methyl}benzamide | non-polymer | 437.4 | 1 | Chemie (3OS) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E (A) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 62 - 302 (UniProt: Q02750)
A: 303 - 393 (UniProt: Q02750)
| PDB | External Database | Details |
|---|---|---|
| Met 61 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| His 394 | - | expression tag |
| His 395 | - | expression tag |
| His 396 | - | expression tag |
| His 397 | - | expression tag |
| His 398 | - | expression tag |
| His 399 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34239.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 968.9 | |
| All* | Total formula weight | 35208.3 |
