PDB: 24 件ウェブページステータス検索Chemie searchBIRD

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1PUF	Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA 分子名称: 5'-D(*AP*CP*TP*CP*TP*AP*TP*GP*AP*TP*TP*TP*AP*CP*GP*AP*CP*GP*CP*T)-3', 5'-D(*TP*AP*GP*CP*GP*TP*CP*GP*TP*AP*AP*AP*TP*CP*AP*TP*AP*GP*AP*G)-3', Homeobox protein Hox-A9, ... 著者 Laronde-Leblanc, N.A, Wolberger, C. 登録日 2003-06-24 公開日 2003-09-02 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 STRUCTURE OF HOXA9 AND PBX1 BOUND TO DNA: HOX HEXAPEPTIDE AND DNA RECOGNITION ANTERIOR TO POSTERIOR Genes Dev., 17, 2003
3V43	Crystal structure of MOZ 分子名称: ACETATE ION, Histone H3.1, Histone acetyltransferase KAT6A, ... 著者 Qiu, Y, Li, F. 登録日 2011-12-14 公開日 2012-06-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription Genes Dev., 26, 2012
2LN0	Structure of MOZ 分子名称: Histone acetyltransferase KAT6A, ZINC ION 著者 Qiu, Y. 登録日 2011-12-15 公開日 2012-06-27 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription. Genes Dev., 26, 2012
2KKF	Solution structure of MLL CXXC domain in complex with palindromic CPG DNA 分子名称: 5'-D(*CP*CP*CP*TP*GP*CP*GP*CP*AP*GP*GP*G)-3', Histone-lysine N-methyltransferase HRX, ZINC ION 著者 Cierpicki, T, Riesbeck, J.E, Grembecka, J.E, Lukasik, S.M, Popovic, R, Omonkowska, M, Shultis, D.S, Zeleznik-Le, N.J, Bushweller, J.H. 登録日 2009-06-18 公開日 2009-12-08 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia. Nat.Struct.Mol.Biol., 17, 2010
5K9D	Crystal structure of human dihydroorotate dehydrogenase at 1.7 A resolution 分子名称: 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, ACETATE ION, CHLORIDE ION, ... 著者 Lewis, T.A, Sykes, D.B, Law, J.M, Munoz, B, Scadden, D.T, Rustiguel, J.K, Nonato, M.C, Schreiber, S.L. 登録日 2016-05-31 公開日 2016-10-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett, 7, 2016
5K9C	Crystal structure of human dihydroorotate dehydrogenase with ML390 分子名称: 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, ACETATE ION, CHLORIDE ION, ... 著者 Lewis, T.A, Sykes, D.B, Law, J.M, Munoz, B, Scadden, D.T, Rustiguel, J.K, Nonato, M.C, Schreiber, S.L. 登録日 2016-05-31 公開日 2016-10-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett, 7, 2016
7F60	Crystal structure of auxiliary protein in complex with human nuclear protein 分子名称: Nuclear pore complex protein Nup98-Nup96, ORF6 protein, mRNA export factor 著者 Gao, X, Cui, S. 登録日 2021-06-23 公開日 2022-09-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport Nat Commun, 13, 2022
7F90	Crystal structure of SARS auxiliary protein in complex with human nuclear protein 分子名称: Nuclear pore complex protein Nup98-Nup96, ORF6 protein, mRNA export factor 著者 Gao, X, Cui, S. 登録日 2021-07-03 公開日 2022-09-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport Nat Commun, 13, 2022
3MDF	Crystal structure of the RRM domain of Cyclophilin 33 分子名称: Peptidyl-prolyl cis-trans isomerase E 著者 Hom, R.A, Chang, P.Y, Roy, S, Mussleman, C.A, Glass, K.C, Seleznevia, A.I, Gozani, O, Ismagilov, R.F, Cleary, M.L, Kutateladze, T.G. 登録日 2010-03-30 公開日 2010-05-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. J.Mol.Biol., 400, 2010
6MAJ	HBO1 is required for the maintenance of leukaemia stem cells 分子名称: 4-fluoro-N'-[(3-hydroxyphenyl)sulfonyl]-5-methyl[1,1'-biphenyl]-3-carbohydrazide, BRD1 protein, GLYCEROL, ... 著者 Ren, B, Peat, T.S, Monahan, B, Dawson, M, Street, I. 登録日 2018-08-27 公開日 2019-12-25 最終更新日 2020-01-22 実験手法 X-RAY DIFFRACTION (2.139 Å) 主引用文献 HBO1 is required for the maintenance of leukaemia stem cells. Nature, 577, 2020
6MAK	HBO1 is required for the maintenance of leukaemia stem cells 分子名称: ACETYL COENZYME *A, BRD1 protein, Histone acetyltransferase KAT7, ... 著者 Ren, B, Peat, T.S, Monahan, B, Dawson, M, Street, I. 登録日 2018-08-27 公開日 2019-12-25 最終更新日 2020-01-22 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 HBO1 is required for the maintenance of leukaemia stem cells. Nature, 577, 2020
2KYX	Solution structure of the RRM domain of CYP33 分子名称: Peptidyl-prolyl cis-trans isomerase E 著者 Park, S, Bushweller, J.H. 登録日 2010-06-09 公開日 2010-08-25 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression . Biochemistry, 49, 2010
2KU7	Solution structure of MLL1 PHD3-Cyp33 RRM chimeric protein 分子名称: MLL1 PHD3-Cyp33 RRM chimeric protein 著者 Song, J, Wang, Z, Patel, D. 登録日 2010-02-12 公開日 2010-07-07 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell(Cambridge,Mass.), 141, 2010
2KYU	The solution structure of the PHD3 finger of MLL 分子名称: Histone-lysine N-methyltransferase MLL, ZINC ION 著者 Park, S, Bushweller, J.H. 登録日 2010-06-08 公開日 2010-08-25 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression. Biochemistry, 49, 2010
3LPY	Crystal structure of the RRM domain of CyP33 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Peptidyl-prolyl cis-trans isomerase E, SULFATE ION 著者 Wang, Z, Patel, D.J. 登録日 2010-02-07 公開日 2010-07-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell(Cambridge,Mass.), 141, 2010
3LQH	Crystal structure of MLL1 PHD3-Bromo in the free form 分子名称: Histone-lysine N-methyltransferase MLL, ZINC ION 著者 Wang, Z, Patel, D.J. 登録日 2010-02-09 公開日 2010-07-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell(Cambridge,Mass.), 141, 2010
3LQI	Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me2 peptide 分子名称: Histone H3, MLL1 PHD3-Bromo, ZINC ION 著者 Wang, Z, Patel, D.J. 登録日 2010-02-09 公開日 2010-07-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell(Cambridge,Mass.), 141, 2010
3LQJ	Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide 分子名称: Histone H3, MLL1 PHD3-Bromo, ZINC ION 著者 Wang, Z, Patel, D.J. 登録日 2010-02-09 公開日 2010-07-07 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell(Cambridge,Mass.), 141, 2010
4GM3	Crystal structure of human WD repeat domain 5 with compound MM-101 分子名称: MM-101, WD repeat-containing protein 5 著者 Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. 登録日 2012-08-15 公開日 2013-07-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.393 Å) 主引用文献 High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc., 135, 2013
4GQ3	Human menin with bound inhibitor MI-2 分子名称: 4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]-6-propylthieno[2,3-d]pyrimidine, DI(HYDROXYETHYL)ETHER, Menin, ... 著者 Shi, A, Murai, M.J, He, S, Lund, G.L, Hartley, T, Purohit, T, Reddy, G, Chruszcz, M, Grembecka, J, Cierpicki, T. 登録日 2012-08-22 公開日 2012-09-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood, 120, 2012
4GQ4	Human menin with bound inhibitor MI-2-2 分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine, ... 著者 Shi, A, Murai, M.J, He, S, Lund, G.L, Hartley, T, Purohit, T, Reddy, G, Chruszcz, M, Grembecka, J, Cierpicki, T. 登録日 2012-08-22 公開日 2012-09-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.27 Å) 主引用文献 Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood, 120, 2012
4GQ6	Human menin in complex with MLL peptide 分子名称: Histone-lysine N-methyltransferase MLL, Menin, PENTAETHYLENE GLYCOL, ... 著者 Shi, A, Murai, M.J, He, S, Lund, G.L, Hartley, T, Purohit, T, Reddy, G, Chruszcz, M, Grembecka, J, Cierpicki, T. 登録日 2012-08-22 公開日 2012-09-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood, 120, 2012
4GM8	Crystal structure of human WD repeat domain 5 with compound MM-102 分子名称: MM-102, WD repeat-containing protein 5 著者 Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. 登録日 2012-08-15 公開日 2013-07-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.601 Å) 主引用文献 High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc., 135, 2013
4GPQ	Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, Menin, ... 著者 Shi, A, Murai, M.J, He, S, Lund, G.L, Hartley, T, Purohit, T, Reddy, G, Chruszcz, M, Grembecka, J, Cierpicki, T. 登録日 2012-08-21 公開日 2012-09-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood, 120, 2012