8JIR
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![BU of 8jir by Molmil](/molmil-images/mine/8jir) | Cryo-EM structure of the GLP-1R/GCGR dual agonist SAR425899-bound human GLP-1R-Gs complex | Descriptor: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yang, L, Zhou, Q.T, Dai, A.T, Zhao, F.H, Chang, R.L, Ying, T.L, Wu, B.L, Yang, D.H, Wang, M.W, Cong, Z.T. | Deposit date: | 2023-05-27 | Release date: | 2023-09-06 | Method: | ELECTRON MICROSCOPY (2.57 Å) | Cite: | Structural analysis of the dual agonism at GLP-1R and GCGR. Proc.Natl.Acad.Sci.USA, 120, 2023
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4P74
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![BU of 4p74 by Molmil](/molmil-images/mine/4p74) | PheRS in complex with compound 3a | Descriptor: | N-[(3S)-1,1-dioxidotetrahydrothiophen-3-yl]-2-[(4-methylphenoxy)methyl]-1,3-thiazole-4-carboxamide, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit | Authors: | Ferguson, A.D. | Deposit date: | 2014-03-25 | Release date: | 2014-06-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability. J.Biol.Chem., 289, 2014
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1CVD
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![BU of 1cvd by Molmil](/molmil-images/mine/1cvd) | |
5J5F
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![BU of 5j5f by Molmil](/molmil-images/mine/5j5f) | X-Ray Crystal Structure of Acetylcholine Binding Protein (AChBP) in Complex with N4,N4-bis[(pyridin-2-yl)methyl]-6-(thiophen-3-yl)pyrimidine-2,4-diamine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholine-binding protein, DIMETHYL SULFOXIDE, ... | Authors: | Kaczanowska, K, Camacho Hernandez, G.A, Harel, M, Taylor, P. | Deposit date: | 2016-04-02 | Release date: | 2017-03-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Substituted 2-Aminopyrimidines Selective for alpha 7-Nicotinic Acetylcholine Receptor Activation and Association with Acetylcholine Binding Proteins. J. Am. Chem. Soc., 139, 2017
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3J92
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![BU of 3j92 by Molmil](/molmil-images/mine/3j92) | Structure and assembly pathway of the ribosome quality control complex | Descriptor: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | Authors: | Shao, S, Brown, A, Santhanam, B, Hegde, R.S. | Deposit date: | 2014-12-02 | Release date: | 2015-01-21 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure and Assembly Pathway of the Ribosome Quality Control Complex. Mol.Cell, 57, 2015
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5JM8
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![BU of 5jm8 by Molmil](/molmil-images/mine/5jm8) | |
1CVH
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![BU of 1cvh by Molmil](/molmil-images/mine/1cvh) | |
3MH8
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![BU of 3mh8 by Molmil](/molmil-images/mine/3mh8) | |
7VCE
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![BU of 7vce by Molmil](/molmil-images/mine/7vce) | Structural studies of human inositol monophosphatase-1 inhibition by ebselen | Descriptor: | Inositol monophosphatase 1 | Authors: | Abuhammad, A, Laurieri, N, Rice, A, Lowe, E.D, McDonough, M.A, Singh, N, Churchill, G.C. | Deposit date: | 2021-09-02 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and biochemical analysis of human inositol monophosphatase-1 inhibition by ebselen. J.Biomol.Struct.Dyn., 2023
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1SWK
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![BU of 1swk by Molmil](/molmil-images/mine/1swk) | CORE-STREPTAVIDIN MUTANT W79F IN COMPLEX WITH BIOTIN AT PH 4.5 | Descriptor: | BIOTIN, CORE-STREPTAVIDIN, EPI-BIOTIN | Authors: | Freitag, S, Le Trong, I, Chilkoti, A, Klumb, L.A, Stayton, P.S, Stenkamp, R.E. | Deposit date: | 1998-01-27 | Release date: | 1999-02-09 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural studies of binding site tryptophan mutants in the high-affinity streptavidin-biotin complex. J.Mol.Biol., 279, 1998
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1SWH
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![BU of 1swh by Molmil](/molmil-images/mine/1swh) | CORE-STREPTAVIDIN MUTANT W79F AT PH 4.5 | Descriptor: | CORE-STREPTAVIDIN | Authors: | Freitag, S, Le Trong, I, Chilkoti, A, Klumb, L.A, Stayton, P.S, Stenkamp, R.E. | Deposit date: | 1998-01-27 | Release date: | 1999-02-09 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural studies of binding site tryptophan mutants in the high-affinity streptavidin-biotin complex. J.Mol.Biol., 279, 1998
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1SWQ
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![BU of 1swq by Molmil](/molmil-images/mine/1swq) | CORE-STREPTAVIDIN MUTANT W120A AT PH 7.5 | Descriptor: | CORE-STREPTAVIDIN | Authors: | Freitag, S, Le Trong, I, Chilkoti, A, Klumb, L.A, Stayton, P.S, Stenkamp, R.E. | Deposit date: | 1998-01-27 | Release date: | 1999-02-09 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural studies of binding site tryptophan mutants in the high-affinity streptavidin-biotin complex. J.Mol.Biol., 279, 1998
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1SWL
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![BU of 1swl by Molmil](/molmil-images/mine/1swl) | CORE-STREPTAVIDIN MUTANT W108F AT PH 7.0 | Descriptor: | CORE-STREPTAVIDIN | Authors: | Freitag, S, Le Trong, I, Chilkoti, A, Klumb, L.A, Stayton, P.S, Stenkamp, R.E. | Deposit date: | 1998-01-27 | Release date: | 1999-02-09 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural studies of binding site tryptophan mutants in the high-affinity streptavidin-biotin complex. J.Mol.Biol., 279, 1998
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4NRA
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![BU of 4nra by Molmil](/molmil-images/mine/4nra) | Crystal Structure of the bromodomain of human BAZ2B in complex with compound-6 E11322 | Descriptor: | 1,2-ETHANEDIOL, 1-(8-chloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)ethanone, Bromodomain adjacent to zinc finger domain protein 2B | Authors: | Chaikuad, A, Felletar, I, Ferguson, F.M, Filippakopoulos, P, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2013-11-26 | Release date: | 2013-12-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain. J.Med.Chem., 56, 2013
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1MX8
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![BU of 1mx8 by Molmil](/molmil-images/mine/1mx8) | |
1DP9
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![BU of 1dp9 by Molmil](/molmil-images/mine/1dp9) | CRYSTAL STRUCTURE OF IMIDAZOLE-BOUND FIXL HEME DOMAIN | Descriptor: | FIXL PROTEIN, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Gong, W, Hao, B, Chan, M.K. | Deposit date: | 1999-12-24 | Release date: | 2000-12-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | New mechanistic insights from structural studies of the oxygen-sensing domain of Bradyrhizobium japonicum FixL. Biochemistry, 39, 2000
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4NRB
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![BU of 4nrb by Molmil](/molmil-images/mine/4nrb) | Crystal Structure of the bromodomain of human BAZ2B in complex with compound-1 N01197 | Descriptor: | 1,2-ETHANEDIOL, Bromodomain adjacent to zinc finger domain protein 2B, N-methyl-2-(tetrahydro-2H-pyran-4-yloxy)benzamide | Authors: | Muniz, J.R.C, Felletar, I, Chaikuad, A, Filippakopoulos, P, Ferguson, F.M, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Ciulli, A, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2013-11-26 | Release date: | 2013-12-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain. J.Med.Chem., 56, 2013
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4FDO
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![BU of 4fdo by Molmil](/molmil-images/mine/4fdo) | Mycobacterium tuberculosis DprE1 in complex with CT319 | Descriptor: | 3-nitro-N-[(1R)-1-phenylethyl]-5-(trifluoromethyl)benzamide, FLAVIN-ADENINE DINUCLEOTIDE, oxidoreductase DprE1 | Authors: | Batt, S.M, Besra, G.S, Futterer, K. | Deposit date: | 2012-05-29 | Release date: | 2012-07-04 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.403 Å) | Cite: | Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors. Proc.Natl.Acad.Sci.USA, 109, 2012
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3ATJ
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![BU of 3atj by Molmil](/molmil-images/mine/3atj) | HEME LIGAND MUTANT OF RECOMBINANT HORSERADISH PEROXIDASE IN COMPLEX WITH BENZHYDROXAMIC ACID | Descriptor: | BENZHYDROXAMIC ACID, CALCIUM ION, PROTEIN (HORSERADISH PEROXIDASE C1A), ... | Authors: | Meno, K, White, C.G, Smith, A.T, Gajhede, M. | Deposit date: | 1998-12-16 | Release date: | 1999-04-28 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural and Catalytical Implications of a F221M Mutation in the Proximal Pocket of Horseradish Peroxidase C (HRP C) To be Published
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2XSP
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![BU of 2xsp by Molmil](/molmil-images/mine/2xsp) | Structure of Cellobiohydrolase 1 (Cel7A) from Heterobasidion annosum | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CELLULOSE 1,4-BETA-CELLOBIOSIDASE, ... | Authors: | Haddad-momeni, M, Hansson, H, Mikkelsen, N.E, Wang, X, Svedberg, J, Sandgren, M, Stahlberg, J. | Deposit date: | 2010-09-29 | Release date: | 2011-10-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural, Biochemical, and Computational Characterization of the Glycoside Hydrolase Family 7 Cellobiohydrolase of the Tree-Killing Fungus Heterobasidion Irregulare. J.Biol.Chem., 288, 2013
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3L0V
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![BU of 3l0v by Molmil](/molmil-images/mine/3l0v) | |
6WHS
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![BU of 6whs by Molmil](/molmil-images/mine/6whs) | GluN1b-GluN2B NMDA receptor in non-active 1 conformation at 3.95 angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | Authors: | Chou, T, Tajima, N, Furukawa, H. | Deposit date: | 2020-04-08 | Release date: | 2020-08-05 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell, 182, 2020
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1MFF
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![BU of 1mff by Molmil](/molmil-images/mine/1mff) | MACROPHAGE MIGRATION INHIBITORY FACTOR Y95F MUTANT | Descriptor: | MACROPHAGE MIGRATION INHIBITORY FACTOR | Authors: | Taylor, A.B, Stamps, S.L, Wang, S.C, Hackert, M.L, Whitman, C.P. | Deposit date: | 1998-10-19 | Release date: | 1999-07-12 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Mechanism of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor: properties of the P1G, P1A, Y95F, and N97A mutants. Biochemistry, 39, 2000
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6WHV
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![BU of 6whv by Molmil](/molmil-images/mine/6whv) | GluN1b-GluN2B NMDA receptor in complex with SDZ 220-040 and L689,560, class 2 | Descriptor: | (2R,4S)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid, (2S)-2-amino-3-[2',4'-dichloro-4-hydroxy-5-(phosphonomethyl)biphenyl-3-yl]propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chou, T, Tajima, N, Furukawa, H. | Deposit date: | 2020-04-08 | Release date: | 2020-08-05 | Method: | ELECTRON MICROSCOPY (4.05 Å) | Cite: | Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell, 182, 2020
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5J5G
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![BU of 5j5g by Molmil](/molmil-images/mine/5j5g) | X-Ray Crystal Structure of Acetylcholine Binding Protein (AChBP) in Complex with 6-(4-methoxyphenyl)-N4,N4-bis[(pyridin-2-yl)methyl]pyrimidine-2,4-diamine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(4-methoxyphenyl)-N~4~,N~4~-bis[(pyridin-2-yl)methyl]pyrimidine-2,4-diamine, Acetylcholine-binding protein, ... | Authors: | Kaczanowska, K, Harel, M, Camacho Hernandez, A.G, Taylor, P. | Deposit date: | 2016-04-02 | Release date: | 2017-03-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.036 Å) | Cite: | Substituted 2-Aminopyrimidines Selective for alpha 7-Nicotinic Acetylcholine Receptor Activation and Association with Acetylcholine Binding Proteins. J. Am. Chem. Soc., 139, 2017
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