4FDO

Mycobacterium tuberculosis DprE1 in complex with CT319

Summary for 4FDO

Entry DOI	10.2210/pdb4fdo/pdb
Related	4FDN 4FDP
Descriptor	oxidoreductase DprE1, FLAVIN-ADENINE DINUCLEOTIDE, 3-nitro-N-[(1R)-1-phenylethyl]-5-(trifluoromethyl)benzamide, ... (4 entities in total)
Functional Keywords	alpha+beta, oxidoreductase, decaprenylphosphoryl-beta-d-ribose, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	1
Total formula weight	53515.16
Authors	Batt, S.M.,Besra, G.S.,Futterer, K. (deposition date: 2012-05-29, release date: 2012-07-04, Last modification date: 2024-04-03)
Primary citation	Batt, S.M.,Jabeen, T.,Bhowruth, V.,Quill, L.,Lund, P.A.,Eggeling, L.,Alderwick, L.J.,Futterer, K.,Besra, G.S. Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors. Proc.Natl.Acad.Sci.USA, 109:11354-11359, 2012 Cited by PubMed: 22733761 DOI: 10.1073/pnas.1205735109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.403 Å)

Structure validation